2-naphthalen-2-yl-N-[3-[4-[3-[(2-naphthalen-2-ylquinolin-4-yl)amino]propyl]piperazin-1-yl]propyl]quinolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-naphthalen-2-yl-N-[3-[4-[3-[(2-naphthalen-2-ylquinolin-4-yl)amino]propyl]piperazin-1-yl]propyl]quinolin-4-amine
• 化学式: C₄₈H₄₆N₆
• 分子量: 706.933
• InChiKey: WNAJMTJAGWODHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  54
• 可旋转键数：
  12
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  56.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,4-双(3-氨基丙基)哌嗪 、 4-chloro-2-(2-naphthyl)quinoline 在 四氯化锡 作用下， 反应 3.5h， 以60%的产率得到2-naphthalen-2-yl-N-[3-[4-[3-[(2-naphthalen-2-ylquinolin-4-yl)amino]propyl]piperazin-1-yl]propyl]quinolin-4-amine
  参考文献：
  名称：

  Bis-4-aminoquinolines: novel triple-helix DNA intercalators and antagonists of immunostimulatory CpG-oligodeoxynucleotides

  摘要：

  Six dimeric 2-(2-naphthyl)quinolin-4-amines with a linker between the amino groups and eight dimeric 2-(4-anilino)quinolin-4-amines linked between the anilino groups were synthesized and evaluated for their interaction with duplex/triplex DNA's and as antagonists of immunostimulatory oligodeoxynucleotides with a CpG-motif (CpG-ODN). The most powerful triple-helix DNA intercalator known to date, with high affinity toward T(.)A(.)T triplets and triplex/duplex selectivity, was found. The potent antagonism of immunostimulatory CpG-ODN by several bis-4-aminoquinolines is not related to their DNA interactions. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00525-4

文献信息

• US6479504B1
  申请人：——

  公开号：US6479504B1

  公开（公告）日：2002-11-12
• Bis-4-aminoquinolines: novel triple-helix DNA intercalators and antagonists of immunostimulatory CpG-oligodeoxynucleotides
  作者：Lucjan Strekowski、Martial Say、Oliwia Zegrocka、Farial A Tanious、W.David Wilson、Lori Manzel、Donald E Macfarlane

  DOI：10.1016/s0968-0896(02)00525-4

  日期：2003.3

  Six dimeric 2-(2-naphthyl)quinolin-4-amines with a linker between the amino groups and eight dimeric 2-(4-anilino)quinolin-4-amines linked between the anilino groups were synthesized and evaluated for their interaction with duplex/triplex DNA's and as antagonists of immunostimulatory oligodeoxynucleotides with a CpG-motif (CpG-ODN). The most powerful triple-helix DNA intercalator known to date, with high affinity toward T(.)A(.)T triplets and triplex/duplex selectivity, was found. The potent antagonism of immunostimulatory CpG-ODN by several bis-4-aminoquinolines is not related to their DNA interactions. (C) 2002 Elsevier Science Ltd. All rights reserved.