5-methyl-2-o-tolyl-oxazole-4-carboxylic acid diethylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-methyl-2-o-tolyl-oxazole-4-carboxylic acid diethylamide
• 英文别名: N,N-diethyl-5-methyl-2-(2-methylphenyl)-1,3-oxazole-4-carboxamide
• 化学式: C₁₆H₂₀N₂O₂
• 分子量: 272.347
• InChiKey: DSEAAMZXOPRRPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  双乙烯酮 、 二乙胺 、 2-甲基苯甲酰胺 生成 5-methyl-2-o-tolyl-oxazole-4-carboxylic acid diethylamide
  参考文献：
  名称：

  Preparation of New Microgel Polymers and Their Application as Supports in Organic Synthesis

  摘要：

  A series of soluble microgel polymers have been synthesized using solution-phase polymerization reactions. In a systematic manner, several variables such as monomer concentration, cross-linker content, reaction solvent and reaction time were examined, and this provided an optimal polymer with both solubility and precipitation characteristics suitable for synthetic applications. Thus, a chemically functionalized microgel polymer was synthesized, and the utility of this polymer in the synthesis of a small array of oxazole compounds has been demonstrated. The advantage of the microgel polymers produced was that they exhibited solution viscosities lower than those of conventional linear polymers even at higher concentrations, and this was found to be beneficial for their precipitation properties. Compounds prepared using the described microgel polymer supports were obtained in similar yields and purity when compared with insoluble resins, and more importantly, the soluble polymer bound intermediates could be analyzed at each step using standard NMR techniques.

  DOI：

  10.1021/jo016362m