2-Cyano-3-(2, 4-dichloro-phenyl)-acrylic acid ethyl ester

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-Cyano-3-(2, 4-dichloro-phenyl)-acrylic acid ethyl ester
• 英文别名: Ethyl (2Z)-2-cyano-3-(2,4-dichlorophenyl)prop-2-enoate；ethyl (Z)-2-cyano-3-(2,4-dichlorophenyl)prop-2-enoate
• 化学式: C₁₂H₉Cl₂NO₂
• 分子量: 270.115
• InChiKey: HDHAZBAICIKTCX-UITAMQMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4-二氯苯甲醛 、 氰乙酸乙酯 在 lanthanum(III) chloride 作用下， 反应 1.5h， 以88%的产率得到2-Cyano-3-(2, 4-dichloro-phenyl)-acrylic acid ethyl ester
  参考文献：
  名称：

  An Efficient Knoevenagel Condensation Catalyzed by LaCl₃.7H₂O in Heterogeneous Medium^#

  摘要：

  Knoevenagel condensation was carried out in absence of solvent with a mild Lewis acid Lanthanum(III) chloride, to prepare substituted alkenes. A systematic study of the reaction to establish the generality of the method has been undertaken with various aldehydes and active methylene compounds.

  DOI：

  10.1081/scc-120025194

文献信息

• An Efficient Knoevenagel Condensation Catalyzed by LaCl₃.7H₂O in Heterogeneous Medium^#
  作者：A. Venkat Narsaiah、K. Nagaiah

  DOI：10.1081/scc-120025194

  日期：2003.11

  Knoevenagel condensation was carried out in absence of solvent with a mild Lewis acid Lanthanum(III) chloride, to prepare substituted alkenes. A systematic study of the reaction to establish the generality of the method has been undertaken with various aldehydes and active methylene compounds.