1,5-bis(4-chlorophenyl)-3-(2-(5-fluoro-2-methoxyphenyl)quinolin-3-yl)pentane-1,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,5-bis(4-chlorophenyl)-3-(2-(5-fluoro-2-methoxyphenyl)quinolin-3-yl)pentane-1,5-dione
• 英文别名: 1,5-Bis(4-chlorophenyl)-3-[2-(5-fluoro-2-methoxyphenyl)quinolin-3-yl]pentane-1,5-dione；1,5-bis(4-chlorophenyl)-3-[2-(5-fluoro-2-methoxyphenyl)quinolin-3-yl]pentane-1,5-dione
• 化学式: C₃₃H₂₄Cl₂FNO₃
• 分子量: 572.463
• InChiKey: SGNUFEWLXHEMAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  56.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-3-喹啉甲醛 、 对氯苯乙酮 、 5-氟-2-甲氧基苯硼酸 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium phosphate 、 三苯基膦 作用下， 以 乙醇 、 水 为溶剂， 反应 5.0h， 以93%的产率得到1,5-bis(4-chlorophenyl)-3-(2-(5-fluoro-2-methoxyphenyl)quinolin-3-yl)pentane-1,5-dione
  参考文献：
  名称：

  Efficient one pot multi-component domino Aldol condensation–Michael addition–Suzuki coupling reaction for the highly functionalized quinolines

  摘要：

  A parallel and advantageous multi-component one pot reaction has been developed utilizing domino Aldol condensation-Michael addition-Suzuki coupling approach for a variety of 2,3-disubstituted highly functionalized quinolines. The domino reactions of 2-chloro-3-formylquinolines, 1 acetophenones, 2 and distinctive boronic acids, 3 were carried out utilizing PdCl2(PPh3)(2)/tripotassium phosphate/ethanol-water system. At 80 degrees C they gave diversified functionalized quinolines in good yields. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.06.040

文献信息

• Efficient one pot multi-component domino Aldol condensation–Michael addition–Suzuki coupling reaction for the highly functionalized quinolines
  作者：Eethamukkala Ubba、Y. Suneel Kumar、C. Dasaradhan、Fazlur-Rahman Nawaz Khan、Euh Duck Jeong、Eun Hyuk Chung

  DOI：10.1016/j.tetlet.2015.06.040

  日期：2015.8

  A parallel and advantageous multi-component one pot reaction has been developed utilizing domino Aldol condensation-Michael addition-Suzuki coupling approach for a variety of 2,3-disubstituted highly functionalized quinolines. The domino reactions of 2-chloro-3-formylquinolines, 1 acetophenones, 2 and distinctive boronic acids, 3 were carried out utilizing PdCl2(PPh3)(2)/tripotassium phosphate/ethanol-water system. At 80 degrees C they gave diversified functionalized quinolines in good yields. (C) 2015 Elsevier Ltd. All rights reserved.