4-[(4-chlorobenzyl)oxy]-1-(4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl)pyridin-2(1H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[(4-chlorobenzyl)oxy]-1-(4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl)pyridin-2(1H)-one
• 英文别名: 4-(4-chlorobenzyloxy)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl)-1H-pyridin-2-one；4-(4-chlorobenzyloxy)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one；4-[(4-Chlorobenzyl)oxy]-1-{4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl}pyridin-2(1H)-one；4-[(4-chlorophenyl)methoxy]-1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]pyridin-2-one
• 化学式: C₂₄H₂₅ClN₂O₃
• 分子量: 424.927
• InChiKey: JLBZQGVJKAWCSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-苄氧基-2(1H)-吡啶酮 在 copper(l) iodide 、 乙醇 、 三丁基膦 、 10% palladium on activated carbon 、 氢气 、 4-甲基苯磺酸吡啶 、 potassium carbonate 、 三苯基膦 、 1,1'-azodicarbonyl-dipiperidine 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 31.0h， 生成 4-[(4-chlorobenzyl)oxy]-1-(4-[2-(pyrrolidin-1-yl)ethoxy]-phenyl)pyridin-2(1H)-one
  参考文献：
  名称：

  Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists

  摘要：

  The design, synthesis and structure-activity relationships of a novel class of N-phenylpyridone MCH1R antagonists are described. The core part of the N-phenylpyridone structure was newly designed and the side chain moieties that were attached to the core part were extensively explored. As a result of optimization of the N-phenylpyridone leads, we successfully developed the orally available, and brain-penetrable MCH1R selective antagonist 7c, exhibiting excellent anti-obese effect in diet-induced obese (DIO) mice. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.002

文献信息

• Pyridone derivative
  申请人：Otake Norikazu

  公开号：US20070208046A1

  公开（公告）日：2007-09-06

  The invention provides pyridone derivatives represented by a general formula (I) [in the formula, R 1 and R 2 may be same or different and stands for H, etc., or R 1 and R 2 may form an aliphatic nitrogen-containing heterocyclic group together with the N to which they bind; X 1 -X 3 may be same or different and stand for methine or N, provided not all of them simultaneously stand for nitrogen; X 4 -X 7 may be same or different and stand for methine or N, provided that three or more of them do not simultaneously stand for N; Y 1 and Y 3 may be same or different and stand for single bond, —O—, —NR—, —S—, etc; Y 2 stands for lower alkylene, etc.; R stands for H, etc., L stands for methylene; Z 1 and Z 2 may be same or different and stand for single bond or lower alkylene; or R 1 , L and Z 2 may form an aliphatic nitrogen-containing heterocyclic group with the N to which R 1 binds; and Ar stands for aromatic carbocyclic group, etc.].

  该发明提供了由通式（I）表示的吡啶酮衍生物[在公式中，R1和R2可能相同或不同，代表H等，或者R1和R2可能与它们结合的N一起形成一个脂肪族含氮杂环基团；X1-X3可能相同或不同，代表亚甲或N，但不能同时都代表氮；X4-X7可能相同或不同，代表亚甲或N，但不能同时有三个或更多同时代表N；Y1和Y3可能相同或不同，代表单键，-O-，-NR-，-S-等；Y2代表较低的烷基等；R代表H等，L代表亚甲基；Z1和Z2可能相同或不同，代表单键或较低的烷基；或者R1、L和Z2可能与R1结合的N一起形成一个脂肪族含氮杂环基团；Ar代表芳香族碳环基团等]。
• PYRIDONE DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1741703A1

  公开（公告）日：2007-01-10

  The invention provides pyridone derivatives represented by a general formula (I) [in the formula, R1 and R2 may be same or different and stands for H, etc., or R1 and R2 may form an aliphatic nitrogen-containing heterocyclic group together with the N to which they bind; X1-X3 may be same or different and stand for methine or N, provided not all of them simultaneously stand for nitrogen; X4-X7 may be same or different and stand for methine or N, provided that three or more of them do not simultaneously stand for N; Y1 and Y3 may be same or different and stand for single bond, -0-, -NR-, -S-, etc ; Y2 stands for lower lkylene, etc.; R stands for H, etc., L stands for methylene; Z1 and Z2 may be same or different and stand for single bond or lower alkylene; or R1, L and Z2 may form an aliphatic nitrogen-containing heterocyclic group with the N to which R1 binds; and Ar stands for aromatic carbocyclic group, etc.].

  本发明提供了通式 (I) 所代表的吡啶酮衍生物 [式中，R1 和 R2 可以相同或不同，代表 H 等、或 R1 和 R2 可与它们结合的 N 一起形成一个脂族含氮杂环基团；X1-X3 可相同或不同，代表甲烷或 N，条件是它们中的三个或更多不同时代表氮；X4-X7 可相同或不同，代表甲烷或 N，条件是它们中的三个或更多不同时代表 N；Y1 和 Y3 可相同或不同，代表单键、-0-、-NR-、-S-等；Y2 代表低级亚烷基等。R 代表 H 等、L 代表亚甲基；Z1 和 Z2 可相同或不同，代表单键或低级亚烷基；或 R1、L 和 Z2 可与 R1 结合的 N 形成脂肪族含氮杂环基团；Ar 代表芳香族碳环基团等]。
• US7732456B2
  申请人：——

  公开号：US7732456B2

  公开（公告）日：2010-06-08
• Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists
  作者：Yuji Haga、Sayaka Mizutani、Akira Naya、Hiroyuki Kishino、Hisashi Iwaasa、Masahiko Ito、Junko Ito、Minoru Moriya、Nagaaki Sato、Norihiro Takenaga、Akane Ishihara、Shigeru Tokita、Akio Kanatani、Norikazu Ohtake

  DOI：10.1016/j.bmc.2010.12.002

  日期：2011.1

  The design, synthesis and structure-activity relationships of a novel class of N-phenylpyridone MCH1R antagonists are described. The core part of the N-phenylpyridone structure was newly designed and the side chain moieties that were attached to the core part were extensively explored. As a result of optimization of the N-phenylpyridone leads, we successfully developed the orally available, and brain-penetrable MCH1R selective antagonist 7c, exhibiting excellent anti-obese effect in diet-induced obese (DIO) mice. (C) 2010 Elsevier Ltd. All rights reserved.