2,6-dimethyl-1-(methylsulfanyl)hept-5-en-2-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,6-dimethyl-1-(methylsulfanyl)hept-5-en-2-ol
• 英文别名: 2,6-Dimethyl-1-methylsulfanylhept-5-en-2-ol；2,6-dimethyl-1-methylsulfanylhept-5-en-2-ol
• 化学式: C₁₀H₂₀OS
• 分子量: 188.334
• InChiKey: MCFJUAQYFHIHAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-甲基-5-庚烯-2-酮 、 三甲基碘化锍 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 以45%的产率得到2-methyl-2-(4-methylpent-3-enyl)oxirane
  参考文献：
  名称：

  Revisiting the Corey–Chaykovsky reaction: the solvent effect and the formation of β-hydroxy methylthioethers

  摘要：

  The classical Corey-Chaykovsky (CC) reaction of ketones in ethereal solvents (i.e., THF or Et2O) resulted in the production of a 14 significant amount of P-hydroxy methylthioether 2 along with normal epoxide product 1. Some interesting and synthetically useful transformations of the CC reaction product of cyclopropyl ketones were also described. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.10.068

文献信息

• Revisiting the Corey–Chaykovsky reaction: the solvent effect and the formation of β-hydroxy methylthioethers
  作者：Yu Peng、Jin-Hui Yang、Wei-Dong Z. Li

  DOI：10.1016/j.tet.2005.10.068

  日期：2006.2

  The classical Corey-Chaykovsky (CC) reaction of ketones in ethereal solvents (i.e., THF or Et2O) resulted in the production of a 14 significant amount of P-hydroxy methylthioether 2 along with normal epoxide product 1. Some interesting and synthetically useful transformations of the CC reaction product of cyclopropyl ketones were also described. (c) 2005 Elsevier Ltd. All rights reserved.