2-methoxyacetic acid 2-oxo-propyl ester

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methoxyacetic acid 2-oxo-propyl ester
• 英文别名: 2-Oxopropyl 2-methoxyacetate
• 化学式: C₆H₁₀O₄
• 分子量: 146.143
• InChiKey: GBDJAAZCTBZVFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-丙炔-1-醇 、 甲氧基乙酸 在 C₄₄H₄₀O₈P₂Ru 、 sodium carbonate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以69%的产率得到2-methoxyacetic acid 2-oxo-propyl ester
  参考文献：
  名称：

  羧酸钌配合物作为将羧酸加成到炔丙醇的有效催化剂

  摘要：

  德国开姆尼茨理工大学的 Heinrich Lang 小组受邀为本期杂志封面。封面图片显示了羧酸与炔丙醇的原子经济性和高选择性加成，以得到 β-氧代丙酯。这种转化由钌配合物催化，由我们图片中的溜冰者代表。

  DOI：

  10.1002/ejic.201500203

文献信息

• THERAPEUTIC AMINE-ARYLSULFONAMIDE CONJUGATE COMPOUNDS
  申请人：MORGAN F. Philip

  公开号：US20070155729A1

  公开（公告）日：2007-07-05

  Therapeutic amine-arylsulfonamide conjugate compounds, of the general formula: wherein R′ is [D-W-], hydroxyl, or alkoxyl; R″ is independently [D-W′-], hydrogen, alkoxy, alkyl, cycloalkyl, alkenyl, alkynyl or aryl, or R″ and R″ together with the nitrogen atom to which they are attached form a 4-, 5-, 6-, 7- or 8-membered ring optionally containing one or two further heteroatoms independently selected from nitrogen, oxygen and sulfur; D is independently a therapeutic amine radical comprising at least one nitrogen atom and optionally at least one oxygen atom coupled to W or W′ by a nitrogen or oxygen atom; W and W′ are a chemical bond or linker; wherein either R′ is [D-W-] or at least one R″ is [D-W′-], and pharmaceutically acceptable esters, amides, salts or solvates thereof, pharmaceutical compositions containing same, methods for their preparation, and their use in treating psychiatric, neurologic and metabolic disorders are disclosed.

  治疗性胺基芳砜酰胺共轭化合物，一般式如下： 其中R′为[D-W-]，羟基或烷氧基；R″独立为[D-W′-]，氢，烷氧基，烷基，环烷基，烯基，炔基或芳基，或R″和R″与它们连接的氮原子一起形成一个含有一个或两个进一步异原子（独立选择自氮、氧和硫）的4、5、6、7或8元环，D独立为至少含有一个氮原子和可选地至少一个氧原子的治疗性胺基基团，通过氮或氧原子与W或W′偶联；W和W′为化学键或连接物；其中R′为[D-W-]或至少一个R″为[D-W′-]，以及其药学上可接受的酯、酰胺、盐或溶剂化合物，含有相同化合物的药物组合物，其制备方法，以及它们在治疗精神病、神经病和代谢性疾病中的用途。
• PROCESS FOR MAKING CHEMICAL DERIVATIVES
  申请人：METABOLIX, INC.

  公开号：US20140024769A1

  公开（公告）日：2014-01-23

  Process and methods for making glycolic acid chemical intermediates and derivatives from biomass are described herein.

  本文描述了从生物质制备甘醇酸化学中间体和衍生物的过程和方法。
• BIODEGRADABLE INTRAVAGINAL DEVICES FOR DELIVERY OF THERAPEUTICS
  申请人：Kiser Patrick F.

  公开号：US20100166826A1

  公开（公告）日：2010-07-01

  The present disclosure relates to biodegradable intravaginal rings for the delivery of therapeutic or prophylactic agent, inter alia, antiviral agents. The present disclosure further relates to biodegradable polyurethanes which will allow therapeutic/prophylactic agents to be released in a controlled manner that will not degrade when in use, but will degrade upon disposal.

  本公开涉及可生物降解的阴道环，用于传递治疗或预防性药物，其中包括抗病毒药物。本公开还涉及可生物降解的聚氨酯，可使治疗/预防性药物以控制的方式释放，使用时不会降解，但在处理时会降解。
• Biodegradable stents
  申请人：Wainwright John

  公开号：US20070050018A1

  公开（公告）日：2007-03-01

  A stent comprising a matrix and a fiber reinforcement about which the matrix is chemically or mechanically attached. The matrix is provided with heavier loads of pharmaceutically active ingredients or genetic materials as a result of the increased strength and mechanical characteristics provided to the stent by the fiber reinforcement. The fiber reinforcement can be comprised of a plurality of mono-filament fibers spaced and oriented in a flat weave pattern to which the matrix is chemically or mechanically attached. Degradation rates of the materials that comprise the matrix and the fiber reinforcement can be varied to vary the time period in which the stent maintains its mechanical characteristics or releases the pharmaceutically active ingredients or genetic materials therefrom. Multiple stage release profiles can be provided by providing multiple layers of matrices and fiber reinforcements, whereby different pharmaceutically active ingredients or genetic materials or different concentrations thereof, can be released according to the degradation profiles of the matrix and fiber reinforcment.
• Bioabsorbable Drain Tube
  申请人：Nishtala Vasu

  公开号：US20090005762A1

  公开（公告）日：2009-01-01

  A bioabsorbable drain tube for the evacuation of fluids and gases from a body cavity or wound to promote healing, such as after chest surgery. The bioabsorbable drain tube includes a first elongated section molded from a bioabsorbable polymer, the first elongated section having a first end, a second end and a plurality of drain openings; and a second elongated section, the second elongated section having a first end and a second end, the first end of the second elongated section in fluid communication with the second end of the first elongated section. A method of draining fluid from a surgical site or wound of a patient is also provided.