摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

3',4,5'-trihydroxy-6-methoxy-2-O-α-L-arabinosylbenzophenone

中文名称
——
中文别名
——
英文名称
3',4,5'-trihydroxy-6-methoxy-2-O-α-L-arabinosylbenzophenone
英文别名
[2-[(2R,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-(3,5-dihydroxyphenyl)methanone
3',4,5'-trihydroxy-6-methoxy-2-O-α-L-arabinosylbenzophenone化学式
CAS
——
化学式
C18H18O10
mdl
——
分子量
394.335
InChiKey
SYHPOJMSCYFEOI-RUGDWHBFSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.9
  • 重原子数:
    28
  • 可旋转键数:
    5
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.28
  • 拓扑面积:
    177
  • 氢给体数:
    7
  • 氢受体数:
    10

反应信息

  • 作为反应物:
    描述:
    参考文献:
    名称:
    Three new benzophenone glycosides with MAO-A inhibitory activity from Hypericum thasium Griseb.
    摘要:
    Purification of n-BuOH fraction from 80% ethanol extract of Hypericum thasium Griseb. resulted in the isolation of three new compounds 3',4,5'-trihydroxy-6-methoxy-2-O-alpha-L-arabinosylbenzophenone (1), 3',4,5',6-tetrahydroxy-2-O-alpha-L-arabinosylbenzophenone (2), and 3',4-dihydroxy-5'-methoxy-2-O-alpha-L-arabinosyl-6-O-beta-D-xylosylbenzophenone (3) along with a known flavonoid glycoside quercetin-3-O-alpha-L-arabinofuranoside (4). The structures of the new compounds were elucidated by 1D and 2D NMR analysis as well as HRESIMS. The isolated compounds (1-4), as well as quercetin, and kaempferol previously isolated from EtOAc fraction were screened against MAO-A inhibitory activity. When tested against the MAO-A quercetin and kaempferol displayed IC50 values of 19.6, and 17.5 mu M, respectively. The IC50 values for MAO-A inhibition by compounds (1-4) were 310.3, 111.2, 726.0, and 534.1 mu M, respectively. Standard inhibitor (clorgyline) exhibited MAO-A inhibition with an IC50 value of 0.5 mu M. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
    DOI:
    10.1016/j.phytol.2012.06.018
点击查看最新优质反应信息

文献信息

  • Three new benzophenone glycosides with MAO-A inhibitory activity from Hypericum thasium Griseb.
    作者:Ozlem Demirkiran
    DOI:10.1016/j.phytol.2012.06.018
    日期:2012.12
    Purification of n-BuOH fraction from 80% ethanol extract of Hypericum thasium Griseb. resulted in the isolation of three new compounds 3',4,5'-trihydroxy-6-methoxy-2-O-alpha-L-arabinosylbenzophenone (1), 3',4,5',6-tetrahydroxy-2-O-alpha-L-arabinosylbenzophenone (2), and 3',4-dihydroxy-5'-methoxy-2-O-alpha-L-arabinosyl-6-O-beta-D-xylosylbenzophenone (3) along with a known flavonoid glycoside quercetin-3-O-alpha-L-arabinofuranoside (4). The structures of the new compounds were elucidated by 1D and 2D NMR analysis as well as HRESIMS. The isolated compounds (1-4), as well as quercetin, and kaempferol previously isolated from EtOAc fraction were screened against MAO-A inhibitory activity. When tested against the MAO-A quercetin and kaempferol displayed IC50 values of 19.6, and 17.5 mu M, respectively. The IC50 values for MAO-A inhibition by compounds (1-4) were 310.3, 111.2, 726.0, and 534.1 mu M, respectively. Standard inhibitor (clorgyline) exhibited MAO-A inhibition with an IC50 value of 0.5 mu M. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
查看更多