4-cyano-N,4-dimethylpentanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-cyano-N,4-dimethylpentanamide
• 化学式: C₈H₁₄N₂O
• 分子量: 154.212
• InChiKey: FHKIPCLITAJMHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-甲基戊酸 在 氯化亚砜 、 2,4,5,6-四(9H-咔唑-9-基)异酞腈 、 碳酸氢钠 、 potassium carbonate 、 caesium carbonate 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 4-cyano-N,4-dimethylpentanamide
  参考文献：
  名称：

  使用亲电氮自由基光诱导酰胺和胺的远程官能化

  摘要：

  远端位置的 C(sp 3 )−H 键与官能团的选择性官能化是合成化学中的一项具有挑战性的任务。这里报道了一种用于酰胺和受保护胺的不同官能化的光诱导自由基级联策略。该过程基于亲电酰胺自由基的氧化生成以及随后通过 1,5-H 原子转移进行的转位，从而实现远程氟化、氯化，并首次实现硫醚化、氰化和炔基化。该过程能够容纳最常见的功能组，并提供可以进一步详细说明的有用构建块。通过氨基酸和二肽的后期功能化证明了该策略的实用性。

  DOI：

  10.1002/anie.201807941

文献信息

• GRAFTED MACROMOLECULAR CONJUGATES OF DOXORUBICIN WITH ANTICANCER ACTIVITY AND METHOD OF THEIR PREPARATION
  申请人：Etrych Tomas

  公开号：US20090306004A1

  公开（公告）日：2009-12-10

  A polymeric drug, in which a cancerostatic connected via spacers containing hydrolytically cleavable hydrazone bonds is bound to a water-soluble polymeric carrier prepared on the basis of a N-(2-hydroxypropyl)methacrylamide copolymer, wherein the structure of the polymeric drug consists of the main chain of N-(2-hydroxypropyl)methacrylamide carrying the cancerostatic and another chain of N-(2-hydroxypropyl)methacrylamide—a graft, which may also carry a cancerostatic, said grafts being bound to the main chain by a bond that is stable in the body and/or by a bond cleavable in the body, especially by an oligopeptide spacer selected from the series of GlyLeuGly, GlyPheGly, GlyPheLeuGly and GlyLeuPheGly, and a method of its preparation.

  一种聚合物药物，其中包含通过含有水解可断裂的酰肼键的间隔连接的抗癌药物，与基于N-（2-羟基丙基）甲基丙烯酰胺共聚物制备的水溶性聚合物载体结合，其中聚合物药物的结构由携带抗癌药物的N-（2-羟基丙基）甲基丙烯酰胺主链和另一条N-（2-羟基丙基）甲基丙烯酰胺链组成，该支链也可以携带抗癌药物，所述支链通过身体内稳定的键和/或身体内可断裂的键与主链结合，特别是通过选自GlyLeuGly、GlyPheGly、GlyPheLeuGly和GlyLeuPheGly系列的寡肽间隔连接，以及其制备方法。
• METHOD FOR PRODUCING COMPOUND HAVING COLORANT STRUCTURE AT MAIN CHAIN TERMINAL OF POLYMER, AND PIGMENT DISPERSANT, PIGMENT COMPOSITION, PIGMENT DISPERSION AND TONER CONTAINING COMPOUND OBTAINED BY THE PRODUCTION METHOD
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20150274853A1

  公开（公告）日：2015-10-01

  To provide a method for producing a compound that enhances dispersibility of a pigment of respective colors in a water-insoluble solvent, as well as a pigment dispersant, and a pigment composition, a pigment dispersion and a toner having a good tinting power. A method for producing a compound, including the following: (i): subjecting a polymerizable monomer forming a monomer unit represented by formula (1) to radical polymerization in the presence of a radical polymerization initiator and an iodine molecule to provide a polymer; and (ii): binding a colorant to a terminal of a main chain of the polymer: wherein R 1 represents a hydrogen atom and an alkyl group, and R 2 represents a phenyl group, a carboxyl group, an alkoxycarbonyl group or a carboxamide group.
• US9556290B2
  申请人：——

  公开号：US9556290B2

  公开（公告）日：2017-01-31
• [EN] GRAFTED MACROMOLECULAR CONJUGATES OF DOXORUBICIN WITH ANTICANCER ACTIVITY AND METHOD OF THEIR PREPARATION<br/>[FR] CONJUGUÉS MACROMOLÉCULAIRES GREFFÉS DE DOXORUBICINE ANTICANCÉREUX ET PROCÉDÉ D'ÉLABORATION
  申请人：ZENTIVA AS

  公开号：WO2008034391A1

  公开（公告）日：2008-03-27

  [EN] A polymeric drug, in which a cancerostatic connected via spacers containing hydrolytically cleavable hydrazone bonds is bound to a water-soluble polymeric carrier prepared on the basis of a N-(2-hydroxypropyl)methacrylamide copolymer, wherein the structure of the polymeric drug consists of the main chain of N-(2-hydroxypropyl)methacrylamide carrying the cancerostatic and another chain of N-(2-hydroxypropyl)methacrylamide - a graft, which may also carry a cancerostatic, said grafts being bound to the main chain by a bond that is stable in the body and/or by a bond cleavable in the body, especially by an oligopeptide spacer selected from the series of GlyLeuGly, GlyPheGly, GlyPheLeuGly and GlyLeuPheGly, and a method of its preparation.
  [FR] Médicament polymère, dans lequel un cancérostatique relié par le biais d'espaceurs contenant des liaisons hydrazone à clivage hydrolytique est lié à un vecteur polymère hydrosoluble élaboré sur la base d'un copolymère N-(2-hydroxypropyl)méthacrylamide, sachant que la structure de ce médicament comprend la chaîne principale de N-(2-hydroxypropyl)méthacrylamide supportant le cancérostatique et une autre chaîne de N-(2-hydroxypropyl)méthacrylamide - une greffe, pouvant également supporter un cancérostatique, ces greffes étant liées à la chaîne principale par une liaison qui est stable dans le corps et/ou par une liaison clivable dans le corps, en particulier un espaceur oligopeptidique pouvant appartenir à la série GlyLeuGly, GlyPheGly, GlyPheLeuGly and GlyLeuPheGly, et enfin procédé d'élaboration correspondant.
• Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals
  作者：Sara P. Morcillo、Elizabeth M. Dauncey、Ji Hye Kim、James J. Douglas、Nadeem S. Sheikh、Daniele Leonori

  DOI：10.1002/anie.201807941

  日期：2018.9.24

  here is a photoinduced radical cascade strategy for the divergent functionalization of amides and protected amines. The process is based on the oxidative generation of electrophilic amidyl radicals and their subsequent transposition by 1,5‐H‐atom transfer, resulting in remote fluorination, chlorination and, for the first time, thioetherification, cyanation, and alkynylation. The process is tolerant

  远端位置的 C(sp 3 )−H 键与官能团的选择性官能化是合成化学中的一项具有挑战性的任务。这里报道了一种用于酰胺和受保护胺的不同官能化的光诱导自由基级联策略。该过程基于亲电酰胺自由基的氧化生成以及随后通过 1,5-H 原子转移进行的转位，从而实现远程氟化、氯化，并首次实现硫醚化、氰化和炔基化。该过程能够容纳最常见的功能组，并提供可以进一步详细说明的有用构建块。通过氨基酸和二肽的后期功能化证明了该策略的实用性。