2-amino-6,8,9-trimethyl-11H-indolo<3,2-c>quinolin-5-inium mesitylenesulfonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-amino-6,8,9-trimethyl-11H-indolo<3,2-c>quinolin-5-inium mesitylenesulfonate
• 英文别名: 2,4,6-trimethylbenzenesulfonate;6,8,9-trimethyl-11H-indolo[3,2-c]quinolin-5-ium-5-amine
• 化学式: C₉H₁₁O₃S*C₁₈H₁₈N₃
• 分子量: 475.612
• InChiKey: DHUZYJWDQUWLSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.92
• 重原子数：
  34
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,4-己二酮 、 2-amino-6,8,9-trimethyl-11H-indolo<3,2-c>quinolin-5-inium mesitylenesulfonate 在 三乙胺 作用下， 以 乙醇 、 丙酮 为溶剂， 以73%的产率得到2,3-diethyl-12,13-dimethyl-10H-indolo<3,2-c>pyridazino<1,6-a>quinolin-5-inium mesitylenesulfonate
  参考文献：
  名称：

  Novel DNA Intercalators Based on the Pyridazino[1‘,6‘:1,2]pyrido[4,3-b]indol-5-inium System

  摘要：

  A new class of DNA intercalators based on the 8H-pyridazino[1',6':1,2]pyrido[4,3-b]indol-5-inium system in which the cationic nature of the chromophore is provided by a brigdehead quaternary nitrogen has been obtained. These cations along with 10H-indolo[3,2-c]pyridazino[1,6-a]quinolin-5-inium, 13H-dibenz[f,h]indolo[3',2':3,4]pyrido[1,2-b]cinnolin-10-inium, and 5H-acenaphtho[1',2: 3',4']pyridazino[1',6':1,2]pyrido[4,3-b]indol-8-inium were synthesized by the Westphal reaction of carbolinium derivatives with various 1,2-dicarbonyl compounds. When these tetra-, penta-, and heptacyclic heteroaromatic nuclei were evaluated as DNA intercalators using UV-vis spectroscopy, viscometric determinations, and unwinding angle determinations, we found that only the 8H-pyridazino[1',6':1,2]pyrido[4,3-b]indol-5-inium cations behaved as DNA intercalators. Molecular modeling studies allowed the preferred orientation of the intercalating chromophore within a CpG intercalation site to be explored and will provide help in the rational design of novel bis-intercalators based on these chromophores.

  DOI：

  10.1021/jo982216d
• 作为产物：
  描述：

  2,4,6-三甲基苯磺酰羟胺 、 6,8,9-trimethyl-11H-indolo<3,2-c>quinoline 以 二氯甲烷 为溶剂， 以6%的产率得到2-amino-6,8,9-trimethyl-11H-indolo<3,2-c>quinolin-5-inium mesitylenesulfonate
  参考文献：
  名称：

  Novel DNA Intercalators Based on the Pyridazino[1‘,6‘:1,2]pyrido[4,3-b]indol-5-inium System

  摘要：

  A new class of DNA intercalators based on the 8H-pyridazino[1',6':1,2]pyrido[4,3-b]indol-5-inium system in which the cationic nature of the chromophore is provided by a brigdehead quaternary nitrogen has been obtained. These cations along with 10H-indolo[3,2-c]pyridazino[1,6-a]quinolin-5-inium, 13H-dibenz[f,h]indolo[3',2':3,4]pyrido[1,2-b]cinnolin-10-inium, and 5H-acenaphtho[1',2: 3',4']pyridazino[1',6':1,2]pyrido[4,3-b]indol-8-inium were synthesized by the Westphal reaction of carbolinium derivatives with various 1,2-dicarbonyl compounds. When these tetra-, penta-, and heptacyclic heteroaromatic nuclei were evaluated as DNA intercalators using UV-vis spectroscopy, viscometric determinations, and unwinding angle determinations, we found that only the 8H-pyridazino[1',6':1,2]pyrido[4,3-b]indol-5-inium cations behaved as DNA intercalators. Molecular modeling studies allowed the preferred orientation of the intercalating chromophore within a CpG intercalation site to be explored and will provide help in the rational design of novel bis-intercalators based on these chromophores.

  DOI：

  10.1021/jo982216d

文献信息

• Novel DNA Intercalators Based on the Pyridazino[1‘,6‘:1,2]pyrido[4,3-<i>b</i>]indol-5-inium System
  作者：Andrés Molina、Juan J. Vaquero、José L. Garcia-Navio、Julio Alvarez-Builla、Beatriz de Pascual-Teresa、Federico Gago、María M. Rodrigo

  DOI：10.1021/jo982216d

  日期：1999.5.1

  A new class of DNA intercalators based on the 8H-pyridazino[1',6':1,2]pyrido[4,3-b]indol-5-inium system in which the cationic nature of the chromophore is provided by a brigdehead quaternary nitrogen has been obtained. These cations along with 10H-indolo[3,2-c]pyridazino[1,6-a]quinolin-5-inium, 13H-dibenz[f,h]indolo[3',2':3,4]pyrido[1,2-b]cinnolin-10-inium, and 5H-acenaphtho[1',2: 3',4']pyridazino[1',6':1,2]pyrido[4,3-b]indol-8-inium were synthesized by the Westphal reaction of carbolinium derivatives with various 1,2-dicarbonyl compounds. When these tetra-, penta-, and heptacyclic heteroaromatic nuclei were evaluated as DNA intercalators using UV-vis spectroscopy, viscometric determinations, and unwinding angle determinations, we found that only the 8H-pyridazino[1',6':1,2]pyrido[4,3-b]indol-5-inium cations behaved as DNA intercalators. Molecular modeling studies allowed the preferred orientation of the intercalating chromophore within a CpG intercalation site to be explored and will provide help in the rational design of novel bis-intercalators based on these chromophores.