1,4-diaza-2,3:8,9-dibenzo-7,10-dioxacyclododecane-5,12-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-diaza-2,3:8,9-dibenzo-7,10-dioxacyclododecane-5,12-dione
• 英文别名: 2,15-Dioxa-5,12-diazatricyclo[14.4.0.06,11]icosa-1(20),6,8,10,16,18-hexaene-4,13-dione
• 化学式: C₁₆H₁₄N₂O₄
• 分子量: 298.298
• InChiKey: PVRJAGAGNDDHHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  bis(1,2-ethylacetoxy)benzene 在 sodium hydroxide 、 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 15.0h， 生成 1,4-diaza-2,3:8,9-dibenzo-7,10-dioxacyclododecane-5,12-dione
  参考文献：
  名称：

  Synthesis, characterization and ion transportation studies of some novel cyclophane amides

  摘要：

  Various novel cyclophane amides with a large cavity have been synthesized. The structures of cyclophane amides 14 and 15 were resolved using XRD studies. Cyclophane amide 28 shows a shift in lambda(max) in the UV/Vis. spectra when treated with Cu (II) ion as well as with Ph(II) ion. Ion transportation studies were carried out with cyclophane amide 14 which proved that the Na+ ion passes through the cavity while K+ ions are retained. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.064

文献信息

• A facile and convenient method for the preparation of macrocyclic diamides
  作者：Hashem Sharghi、Khodabakhsh Niknam、Ahmad Reza Massah

  DOI：10.1002/jhet.5570360304

  日期：1999.5

  A number of macrocyclic diamides have been synthesized from the reaction of a diacid dicarboxylic dichloride with primary diamino compound in the presence of magnesium oxide-silica gel at room temperature in good yields. Using urea and thiourea as well as diamines to produce the corresponding macrocycles in the range of 52–56% yields are also included in this paper. One of the major advantages of this

  在室温下在氧化镁-硅胶存在下，由二酸二羧酸二氯化物与伯二氨基化合物的反应以高收率合成了许多大环二酰胺。本文还包括使用尿素和硫脲以及二胺生产相应的大环化合物，其收率范围为52-56％。该方法的主要优点之一是无机固体的简单再生，并且可以在不降低活性的情况下经过数个循环再利用。
• Synthesis, characterization, and anti-bacterial efficacy of some novel cyclophane amide
  作者：Perumal Rajakumar、A. Mohammed Abdul Rasheed、P.M. Balu、K. Murugesan

  DOI：10.1016/j.bmc.2006.07.020

  日期：2006.11

  Synthesis of macrocyclic di, tetra- and hexaamides with aza and oxy linkages has been achieved and the inhibitory activity of cyclophane amides against human pathogenic bacteria well documented. (c) 2006 Elsevier Ltd. All rights reserved.
• Synthesis, characterization and ion transportation studies of some novel cyclophane amides
  作者：Perumal Rajakumar、A. Mohammed Abdul Rasheed

  DOI：10.1016/j.tet.2005.03.064

  日期：2005.5

  Various novel cyclophane amides with a large cavity have been synthesized. The structures of cyclophane amides 14 and 15 were resolved using XRD studies. Cyclophane amide 28 shows a shift in lambda(max) in the UV/Vis. spectra when treated with Cu (II) ion as well as with Ph(II) ion. Ion transportation studies were carried out with cyclophane amide 14 which proved that the Na+ ion passes through the cavity while K+ ions are retained. (c) 2005 Elsevier Ltd. All rights reserved.