作者:Zhongbo Fei、Quanbing Wu、Lei Li、Qun Jiang、Bin Li、Like Chen、Hao Wang、Bin Wu、Xianwen Wang、Feng Gao、Wenlong Qiu、Jing Guo、Chi Ming Cheung
DOI:10.1021/acs.joc.9b01916
日期:2020.6.5
A new synthesis of LYS228, fitting for further process development for commercial manufacture, is described. The key features of this synthesis include development of new protocols for acylation reactions, application of an asymmetric hydrogenation via dynamic kinetic resolution, and a late-stage ring closure to form β-lactam 1.
描述了LYS228的新合成方法,适用于商业生产的进一步工艺开发。该合成的关键特征包括开发新的酰化反应方案,通过动态动力学拆分应用不对称氢化以及后期闭环形成β-内酰胺1。