2-Deoxy-~-glucono-l,5-lactone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 2-Deoxy-~-glucono-l,5-lactone
• 英文别名: 2-deoxy-D-glucono-1,5-lactone；(4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-one
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: DBXNZGWNBVNDSO-KODRXGBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  D-葡萄烯糖 在 iron(II) acetylacetonate 、 三乙氧基硅烷 、 氧气 作用下， 以 叔丁醇 为溶剂， 反应 24.0h， 以65%Chromat.的产率得到2-Deoxy-~-glucono-l,5-lactone
  参考文献：
  名称：

  一种铁催化氧化烯合成酮的方法

  摘要：

  本发明公开了一种铁催化氧化烯合成酮的方法，属于催化合成技术和精细化学品合成领域。本发明的具体方法是在氢硅烷的促进作用下，以空气或氧气为氧化剂，铁催化氧化烯合成酮类化合物。本发明方法具有催化剂来源广泛、廉价和环保的优势；氧化剂来源广泛、廉价和不产生废物；反应条件温和、选择性高和产率高；底物来源广泛且稳定；底物官能团相容性好且底物的适用范围广；复杂烯分子能很好的转化成酮。在优化的反应条件之下，目标产品分离收率高达98%。

  公开号：

  CN106748690B

文献信息

• Compositions for the treatment of dermatological diseases and disorders
  申请人：CLARIDEI LABORATORIES, INC.

  公开号：US10918652B2

  公开（公告）日：2021-02-16

  The present disclosure is directed to topical dermatological formulations, dermatological cleansing compositions, and bathwater conditioners designed to acidify the skin, and their use for restoring epidermal acidity, restoring a the epidermal barrier, inhibiting inflammation, establishing an environment appropriate for maintaining a balanced symbiotic microbiome, and inhibiting the growth of pathogenic microorganisms in the epidermis—the outer layer of mammalian skin.

  本公开涉及旨在酸化皮肤的皮肤病外用制剂、皮肤病清洁组合物和洗澡水调节剂，以及它们用于恢复表皮酸度、恢复表皮屏障、抑制炎症、建立适合维持平衡共生微生物群的环境，以及抑制病原微生物在表皮--哺乳动物皮肤的外层--的生长。
• Glucono delta-lactone for treatment of vaginal fungal infections
  申请人：GEDEA BIOTECH AB

  公开号：US10993907B2

  公开（公告）日：2021-05-04

  The present invention relates to a pharmaceutical formulation for vaginal administration, wherein the formulation comprises a pharmaceutical acceptable excipient and glucono δ-lactone, wherein the glucono δ-lactone is present in an amount of 5 to 99 wt % of the formulation. The invention also relates to a pharmaceutical formulation according to the invention for use in the prevention or treatment of a urogenital fungal infection. Furthermore, the invention relates to glucono δ-lactone (formula (III)), for use in the in the prevention or treatment of a fungal infection.

  本发明涉及一种用于阴道给药的药物制剂，其中该制剂包括药物可接受赋形剂和葡糖酸 δ-内酯，其中葡糖酸 δ-内酯的含量占制剂的 5 至 99 wt %。本发明还涉及一种根据本发明制成的药物制剂，用于预防或治疗泌尿生殖道真菌感染。此外，本发明还涉及用于预防或治疗真菌感染的葡糖酸 δ-内酯（式（III））。
• Formulations for epidermal repair
  申请人：CLARIDEI LABORATORIES, INC.

  公开号：US11135184B2

  公开（公告）日：2021-10-05

  The present disclosure is directed to dermatological formulations and their use for treating a variety of dermatological diseases and disorders, and for repairing and restoring a disrupted epidermal barrier, inhibiting inflammation, restoring a proper environment for maintaining a balanced symbiotic microbiome, and inhibiting the growth of pathogenic microorganisms in the epidermis—the outer layer of mammalian skin.

  本公开涉及用于治疗多种皮肤病和疾病的制剂及其用途，并用于修复和恢复受损的表皮屏障，抑制炎症，恢复适合保持平衡共生菌群的适当环境，以及抑制表皮（哺乳动物皮肤的外层）中病原微生物的生长。
• Rare Keto-Aldoses from Enzymatic Oxidation: Substrates and Oxidation Products of Pyranose 2-Oxidase
  作者：Stefan Freimund、Alexander Huwig、Friedrich Giffhorn、Sabine Köpper

  DOI：10.1002/(sici)1521-3765(19981204)4:12<2442::aid-chem2442>3.0.co;2-a

  日期：1998.12.4
• COMPOSITIONS FOR THE TREATMENT OF DERMATOLOGICAL DISEASES AND DISORDERS
  申请人：Eberting Cheryl Lee

  公开号：US20170173056A1

  公开（公告）日：2017-06-22

  The present disclosure is directed to topical dermatological formulations, dermatological cleansing compositions, and bathwater conditioners designed to acidify the skin, and their use for restoring epidermal acidity, restoring a the epidermal barrier, inhibiting inflammation, establishing an environment appropriate for maintaining a balanced symbiotic microbiome, and inhibiting the growth of pathogenic microorganisms in the epidermis—the outer layer of mammalian skin.