2-(mesitylsulfonyl)-1-phenylethan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(mesitylsulfonyl)-1-phenylethan-1-one
• 英文别名: 1-Phenyl-2-(2,4,6-trimethylphenyl)sulfonylethanone
• 化学式: C₁₇H₁₈O₃S
• 分子量: 302.394
• InChiKey: ILMDJKLKHFJJMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,4,6-三甲基苯磺酰氯 在 tetrabutylammonium tetrafluoroborate 、 一水合肼 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 14.5h， 生成 2-(mesitylsulfonyl)-1-phenylethan-1-one
  参考文献：
  名称：

  乙烯基叠氮化物的无金属电化学偶联：菲啶和β-酮砜的合成

  摘要：

  据报道，分别通过联芳基乙烯基叠氮化物与叠氮化钠和苯磺酰肼的电化学氧化环偶联，可有效地和环保地合成菲啶。该反应在室温下在无分隔的池中进行，无需额外的金属催化或外源氧化剂。

  DOI：

  10.1002/ejoc.202001059

文献信息

• Photo‐Mediated Decarboxylative Ketonization of Atropic Acids with Sulfonyl Hydrazides: Direct Access to <i>β</i> ‐Ketosulfones
  作者：Jie Chen、Zoe G. Allyson、Jing‐Rui Xin、Zhi Guan、Yan‐Hong He

  DOI：10.1002/adsc.201901525

  日期：2020.5.12

  synthetically and biologically relevant β‐ketosulfones via a photo‐mediated decarboxylative ketonization of atropic acids was disclosed. The approach features metal‐free conditions, good functional group compatibility, readily available starting materials and the use of ubiquitous dioxygen as both oxygen source and oxidant. Furthermore, mechanistic studies reveal that the decarboxylative ketonization

  公开了通过无光子酸的光介导的脱羧酮化作用，有效形成合成和生物学上相关的β-酮砜的方法。该方法的特点是无金属条件，良好的官能团相容性，易于获得的原料以及使用普遍存在的双氧作为氧源和氧化剂。此外，机理研究表明，脱羧酮化反应是通过自由基机理进行的，并且可能涉及自由基链反应。
• One-pot synthesis of β-ketosulfones from sulfonyl chloride, hydrazine hydrate and vinyl azide in water
  作者：Yaohong Zhang、Mengqiang Luo、Yan Li、Runfu Shen、Chenze Qi、Hai Wang、Kai Cheng

  DOI：10.1016/j.tet.2020.131635

  日期：2020.11

  A novel, facile and efficient strategy for the one-pot synthesis of β-ketosulfones from readily available sulfonyl chloride, hydrazine hydrate and vinyl azides is described. The reaction proceeded very smoothly affording diverse β-ketosulfones in moderate to good yields. This new procedure has the advantages of environmental benign, easy and simple operation, low cost and wide tolerance of functional

  描述了一种从容易获得的磺酰氯，水合肼和乙烯基叠氮化物一锅合成β-酮砜的新颖，简便，有效的策略。反应进行得非常顺利，以中等至良好的收率得到了多种β-酮砜。该新方法具有环境友好，操作简便，成本低廉和对官能团的耐受性强的优点，为获得β-酮砜提供了一个非常引人入胜的方案。
• Cu(OTf)₂-Catalyzed efficient sulfonylation of vinyl azides with sodium sulfinates
  作者：Zhitao Ning、Zheng Xu、Ruikai Liu、Zhengyin Du

  DOI：10.1080/00397911.2021.1983603

  日期：2021.11.17

  Abstract A simple oxidative cross-coupling reaction between vinyl azides and sodium sulfinates was developed. This reaction uses commercial arylsulfinates that are more efficient, cheaper, and more stable as sulfonylation reagents, for efficiently, cheaply, and environmentally friendly synthesis of β-keto sulfones. And the reaction has the advantages of simple operation, high efficiency, good yield

  摘要 开发了乙烯基叠氮化物和亚磺酸钠之间的简单氧化交叉偶联反应。该反应使用更高效、更便宜且更稳定的商业芳基亚磺酸盐作为磺酰化试剂，用于高效、廉价且环保地合成 β-酮砜。该反应具有操作简单、效率高、收率好、官能团耐受范围广等优点。
• [EN] LATENT ACIDS AND THEIR USE<br/>[FR] ACIDES LATENTS ET LEUR UTILISATION
  申请人：BASF SE

  公开号：WO2016124493A1

  公开（公告）日：2016-08-11

  Compounds of the formula (I) and (IA) wherein X is -O(CO)-; R1 is C1-C12haloalkyl or C6-C10haloaryl; R2 is located in position 7 of the coumarinyl ring and is OR8; R2a, R2b and R2C independently of each other are hydrogen; R3 is C1-C8haloalkyl or C1-C8haloalkyl; R4 is hydrogen; and R8 is C1-C6alkyI; are suitable as photosensitive acid donors in the preparation of photoresist compositions such as used for example in the preparation of spacers, insulating layers, interlayer dielectric films, insulation layers, planarization layers, protecting layers, overcoat layers, banks for electroluminescence displays and liquid crystal displays (LCD).

  化合物的化学式（I）和（IA），其中X为-O(CO)-；R1为C1-C12卤代烷基或C6-C10卤代芳基；R2位于香豆素环的第7位，为OR8；R2a、R2b和R2C彼此独立地为氢；R3为C1-C8卤代烷基或C1-C8卤代烷基；R4为氢；R8为C1-C6烷基，适用于作为感光酸给体，用于制备光刻胶组合物，例如用于制备间隔层、绝缘层、层间介质膜、绝缘层、平坦化层、保护层、覆盖层、电致发光显示器和液晶显示器（LCD）的制备。
• METHOD FOR PRODUCING COMPOUND HAVING ACID-LABILE GROUP
  申请人：Kyowa Hakko Chemical Co., Ltd.

  公开号：EP1661918A1

  公开（公告）日：2006-05-31

  The present invention provides a process for producing a compound having a group represented by general formula (II): (wherein R1, R2, and R3 may be the same or different, and each represent a substituted or unsubstituted alkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted aralkyl, or R1 and R2 may bind to each other to form an alicyclic hydrocarbon ring together with the adjacent carbon atoms, or R2 and R3 may bind to each other to form a alicyclic heterocyclic ring together with the adjacent O-C-C that may have a substituent), which comprises allowing a compound having a hydroxyl group to react with halogenated alkyl ether represented by general formula (I): (wherein R1, R2, and R3 are the same as those defined above, respectively and X represents a halogen atom).

  本发明提供了一种生产具有由通式（II）表示的基团的化合物的方法：（其中R1、R2和R3可以相同也可以不同，并且分别表示取代或未取代的烷基、取代或未取代的芳基、或取代或未取代的芳基烷基，或者R1和R2可以相互结合形成与相邻碳原子一起的脂环碳氢环，或者R2和R3可以相互结合形成与相邻的O-C-C一起具有取代基的脂环杂环）的方法，该方法包括允许具有羟基的化合物与由通式（I）表示的卤代烷基醚发生反应：（其中R1、R2和R3分别与上述定义相同，X代表卤素原子）。