N-acridin-4-ylmethyl-2,2-diphenylacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-acridin-4-ylmethyl-2,2-diphenylacetamide
• 英文别名: N-(acridin-4-ylmethyl)-2,2-diphenylacetamide
• 化学式: C₂₈H₂₂N₂O
• 分子量: 402.495
• InChiKey: HMNSTJXQXMPTOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苯基乙酰氯 、 在 sodium hydroxide 作用下， 以 水 、 丙酮 为溶剂， 以88%的产率得到N-acridin-4-ylmethyl-2,2-diphenylacetamide
  参考文献：
  名称：

  Synthesis and Crystallographic Studies of New Acridinic Esters and Amides: An Efficient Synthetic Route to 4-Methyl Functionalized Acridines

  摘要：

  In order to open a new way in antitumor drugs research, an efficient synthetic route to mono functional 4-substitued acridine derivatives has been developed on the basis of direct electrophilic substitution of acridine. This method leads to a wide range of simple acridinic patterns that can be linked to various side chains. We present here the synthesis of two new families of acridine ester and amide derivatives, obtained from acridinic alcohol and amine respectively, with high yields. Some crystallographic aspects of one representative compound of each family are discussed.

  DOI：

  10.3987/com-03-9778