2-mercaptothiazolo[5,4-b]quinoline-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-mercaptothiazolo[5,4-b]quinoline-4-carboxylic acid
• 英文别名: 2-sulfanylidene-1H-[1,3]thiazolo[5,4-b]quinoline-9-carboxylic acid
• 化学式: C₁₁H₆N₂O₂S₂
• 分子量: 262.313
• InChiKey: OTSXBOJMUSMODJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  靛红 、 2-巯基噻唑啉 以 四氢呋喃 为溶剂， 反应 48.0h， 以50%的产率得到2,4'-dihydro-2-[2'-mercaptothiazolidine]indol-3-one
  参考文献：
  名称：

  REACTION OF 2-THIAZOLINE-2-THIOL WITH ISATIN DERIVATIVES

  摘要：

  The reaction of indol-2,3-dione derivatives with 2-thiazoline-2-thiol under thermal as well as photochemical conditions is described. Under refluxing ethanol it afforded 3,4'-dihydro-3-[2'-mercaptothiazolidine]indol-2-one. UV light-induced irradiation produced isomeric 2,4-dihydro-2[2'-mercapto- thiazolidine]indol-3-one and 2-mercapto-thiazolo[5,4-b]quinoline-4-carboxylic acid. The synthesized compounds were characterized by elemental analyses and spectral studies and were screened for antimicrobial activity.

  DOI：

  10.1080/10426509808029676

文献信息

• REACTION OF 2-THIAZOLINE-2-THIOL WITH ISATIN DERIVATIVES
  作者：R. T. Pardasani、P. Pardasani、S. Muktawat、V. Chaturvedi、T. Mukherjee

  DOI：10.1080/10426509808029676

  日期：1998.11.1

  The reaction of indol-2,3-dione derivatives with 2-thiazoline-2-thiol under thermal as well as photochemical conditions is described. Under refluxing ethanol it afforded 3,4'-dihydro-3-[2'-mercaptothiazolidine]indol-2-one. UV light-induced irradiation produced isomeric 2,4-dihydro-2[2'-mercapto- thiazolidine]indol-3-one and 2-mercapto-thiazolo[5,4-b]quinoline-4-carboxylic acid. The synthesized compounds were characterized by elemental analyses and spectral studies and were screened for antimicrobial activity.