2-isopropyl-3-(2,2,2-trifluoroethoxy)pyridine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-isopropyl-3-(2,2,2-trifluoroethoxy)pyridine
• 英文别名: 2-propan-2-yl-3-(2,2,2-trifluoroethoxy)pyridine
• 化学式: C₁₀H₁₂F₃NO
• 分子量: 219.207
• InChiKey: DJKZKGVZEFABRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  亚硝酸特丁酯 、 3-amino-2-isopropylthiopyridine 、 2,2,2-三氟乙醇 在 甲烷磺酸 作用下， 以94%的产率得到2-isopropyl-3-(2,2,2-trifluoroethoxy)pyridine
  参考文献：
  名称：

  3-substituted pyridine compounds and related synthesis

  摘要：

  本发明涉及3-取代和2,3-二取代的吡啶化合物，这些化合物在吡啶磺酰脲除草剂的合成中作为中间体有用。本发明还涉及使用吡啶重氮盐进行醇的芳基化反应。更具体地说，本发明的芳基化过程涉及通过无水重氮化3-氨基吡啶来合成2,3-二取代的吡啶化合物，以形成重氮盐中间体，然后与适当的醇反应以产生所需的产物。本发明还涉及吡啶-3-重氮盐中间体。

  公开号：

  US20010006805A1

文献信息

• Diazonium salts which are intermediates for 3-substituted pyridines
  申请人：Syngenta Participations AG

  公开号：US06710180B2

  公开（公告）日：2004-03-23

  The present invention relates to 3-substituted and 2,3-disubstituted pyridine compounds which are useful as intermediates in the synthesis of pyridylsulfonylurea herbicides. The invention also relates to arylation of alcohols using a pyridinediazonium salt. More particularly the arylation process of the instant invention relates to the synthesis of 2,3-disubstituted pyridine compounds via anhydrous diazotization of 3-amninopyridines to form a diazonium salt intermediate that is then reacted with the appropriate alcohol to produce the desired product. The invention additionally relates to pyridine-3-diazonium salt intermediates.

  本发明涉及3-取代和2,3-双取代吡啶化合物，可用作合成吡啶磺酰脲除草剂的中间体。本发明还涉及使用吡啶重氮盐对醇进行芳基化反应。特别是，本发明的芳基化过程涉及通过3-氨基吡啶的无水重氮化形成重氮盐中间体，然后与适当的醇反应，以产生所需的产物的2,3-双取代吡啶化合物的合成。本发明还涉及吡啶-3-重氮盐中间体。
• Spiropiperidine allosteric modulators of nicotinic acetylcholine receptors
  申请人：Merck Sharp & Dohme Corp.

  公开号：US11332463B2

  公开（公告）日：2022-05-17

  The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).

  本公开涉及可用作 7 nAChR 调节剂的式 I 化合物、包含此类化合物的组合物，以及使用此类化合物预防、治疗或改善疾病，特别是中枢神经系统疾病，如阿尔茨海默病、帕金森病和精神分裂症中的认知障碍，以及 L-DOPA 诱导的运动障碍和炎症 (I)。
• 3-SUBSTITUTED PYRIDINE COMPOUNDS AND RELATED SYNTHESIS
  申请人：Syngenta Participations AG

  公开号：EP1098881A1

  公开（公告）日：2001-05-16
• SPIROPIPERIDINE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20210070745A1

  公开（公告）日：2021-03-11

  The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
• SUBSTITUTED HETEROCYCLIC AMIDE COMPOUND AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
  申请人：GENFLEET THERAPEUTICS (SHANGHAI) INC.

  公开号：US20220177462A1

  公开（公告）日：2022-06-09

  A substituted heterocyclic amide compound having a selective inhibitory effect on RIPK1, and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and the use of same in the preparation of a drug for treating a RIPK1-related diseases or conditions.