(2E)-3-(2-bromophenyl)-1-pyridin-3-ylprop-2-en-1-one | 1132818-01-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (2E)-3-(2-bromophenyl)-1-pyridin-3-ylprop-2-en-1-one
• 英文别名: (E)-3-(2-bromophenyl)-1-pyridin-3-ylprop-2-en-1-one
• CAS: 1132818-01-9
• 化学式: C₁₄H₁₀BrNO
• 分子量: 288.143
• InChiKey: VLVUTXPJSIVXJA-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  lithio dimethyl (2-oxo-2-pyridin-3-ylethyl)phosphonate 、 邻溴苯甲醛 以 四氢呋喃 为溶剂， 以77%的产率得到(2E)-3-(2-bromophenyl)-1-pyridin-3-ylprop-2-en-1-one
  参考文献：
  名称：

  A practical preparation of aryl β-ketophosphonates

  摘要：

  The condensation of alkyl phosphonates with aryl esters to give beta-ketophosphonates may be carried out at elevated temperatures mediated by LiHMDS under Barbier type conditions. The reaction is scalable, does not require specialized cryogenic equipment, and is general for all aryl and heteroaryl esters examined. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.11.112

文献信息

• A practical preparation of aryl β-ketophosphonates
  作者：Robert R. Milburn、Ken McRae、Johann Chan、Jason Tedrow、Robert Larsen、Margaret Faul

  DOI：10.1016/j.tetlet.2008.11.112

  日期：2009.2

  The condensation of alkyl phosphonates with aryl esters to give beta-ketophosphonates may be carried out at elevated temperatures mediated by LiHMDS under Barbier type conditions. The reaction is scalable, does not require specialized cryogenic equipment, and is general for all aryl and heteroaryl esters examined. (C) 2008 Elsevier Ltd. All rights reserved.