2-Methyl-2-ethylbut-3-en-1-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-2-ethylbut-3-en-1-ol
• 英文别名: 2-Ethyl-2-methylbut-3-en-1-ol
• 化学式: C₇H₁₄O
• mdl: MFCD27980646
• 分子量: 114.188
• InChiKey: LDUFZYPBRHVUPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  diethylzinc 、 一氧化异戊二烯 在 O,O'-(S)-(1,1'-dinaphthyl-2,2'-diyl)-N,N'-di-(S, S)-[phenylethylphosphoramidite] 、 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 甲苯 为溶剂， 反应 5.0h， 生成 2-Methyl-2-ethylbut-3-en-1-ol 、 2-甲基-2-己烯-1-醇Z异构体 、 2-甲基己-2-烯-1-醇
  参考文献：
  名称：

  Catalytic Regiodivergent Kinetic Resolution of Allylic Epoxides:  A New Entry to Allylic and Homoallylic Alcohols with High Optical Purity

  摘要：

  A novel regiodivergent kinetic resolution of a series of allylic epoxides with alkylzinc reagents is described. Results demonstrate the potential of chiral copper-phosphoramidite catalysts for enantiomer differentiation of allylic epoxides, allowing a chiral catalyst-stereoregulated synthesis of cyclic allylic and homoallylic alcohols with high optical purities.

  DOI：

  10.1021/jo035674h

文献信息

• Catalytic Regiodivergent Kinetic Resolution of Allylic Epoxides:  A New Entry to Allylic and Homoallylic Alcohols with High Optical Purity
  作者：Mauro Pineschi、Federica Del Moro、Paolo Crotti、Valeria Di Bussolo、Franco Macchia

  DOI：10.1021/jo035674h

  日期：2004.3.1

  A novel regiodivergent kinetic resolution of a series of allylic epoxides with alkylzinc reagents is described. Results demonstrate the potential of chiral copper-phosphoramidite catalysts for enantiomer differentiation of allylic epoxides, allowing a chiral catalyst-stereoregulated synthesis of cyclic allylic and homoallylic alcohols with high optical purities.