2-nitro-4-hydroxycinnamic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-nitro-4-hydroxycinnamic acid
• 英文别名: (E)-3-(4-hydroxy-2-nitrophenyl)prop-2-enoic acid
• 化学式: C₉H₇NO₅
• 分子量: 209.158
• InChiKey: LOUNPIXUUSHWMS-DUXPYHPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-nitro-4-hydroxycinnamic acid 、 甘氨酸叔丁酯 生成 tert-butyl 2-[[(E)-3-(4-hydroxy-2-nitrophenyl)prop-2-enoyl]amino]acetate
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  2-nitrocinnamic acid 在 氧气 、 还原型辅酶II(NADPH)四钠盐 作用下， 以 various solvent(s) 为溶剂， 生成 2-nitro-4-hydroxycinnamic acid
  参考文献：
  名称：

  Non-natural cinnamic acid derivatives as substrates of cinnamate 4-hydroxylase

  摘要：

  Cinnamate 4-hydroxylase (C4H), a monooxygenase in the plant phenylpropanoid pathway, was assayed for its ability to hydroxylate 29 substrate analogues. Nine of the tested analogues with various aromatic side chains, including 3-coumaric acid, were metabolized by C4H. Seven products from these reactive analogues were characterized using LC/MS, H-1 NMR and C-13 NMR spectroscopic analysis. For example, caffeic acid was the product of 3-coumaric acid. The products 4-hydroxy-2-chlorocinnamic acid and 4-hydroxy-2-ethoxy-cinnamic acid are novel compounds that have not been previously reported. The kinetic parameters of C4H towards these analogues were determined. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.phytochem.2006.10.018

文献信息

• Acetaminophen analogs, antigens, and antibodies
  申请人：SYVA COMPANY

  公开号：EP0095229A2

  公开（公告）日：1983-11-30

  Carbonyl derivatives of acetaminophen are provided for use in homogeneous enzyme immunoassays for acetaminophen. The derivatives are conjugated to antigenic substances for the preparation of antisera specific to acetaminophen, and to enzymes for the peparation of enzyme conjugates which compete with acetaminophen for antibody binding sites in a typical assay.

  对乙酰氨基酚的羰基衍生物可用于对乙酰氨基酚的均相酶免疫测定。这些衍生物与抗原物质共轭，用于制备对乙酰氨基酚特异性抗血清；与酶共轭，用于分离在典型测定中与对乙酰氨基酚竞争抗体结合位点的酶共轭物。
• ——
  作者：KHANNA P.

  DOI：——

  日期：——
• US4424150A
  申请人：——

  公开号：US4424150A

  公开（公告）日：1984-01-03
• US4504413A
  申请人：——

  公开号：US4504413A

  公开（公告）日：1985-03-12
• US4605754A
  申请人：——

  公开号：US4605754A

  公开（公告）日：1986-08-12