octyl 3,5-dihydroxybenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: octyl 3,5-dihydroxybenzoate
• 英文别名: 3,5-Dihydroxy-benzoic acid octyl ester
• 化学式: C₁₅H₂₂O₄
• 分子量: 266.337
• InChiKey: OMZQFMDEGBTFFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-bromohexanoic acid hexylamide 、 octyl 3,5-dihydroxybenzoate 在 四丁基溴化铵 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  一系列同源酯二酰胺的自组装性质-从碳带到纳米管†

  摘要：

  我们研究了一系列带有两个酰胺基和一个酯烷基链的化合物BHPB- n的聚集性质。该烷基链中的碳原子数（n）为5至16。这些化合物在烷烃中形成低浓度的凝胶。凝胶的浓度和形成凝胶，通过DSC测量的预赛，分为三个不同的制度：Ñ ≤7,8≤ Ñ ≤12和Ñ ≥13.冷冻断裂透射电镜显示，所有化合物自组装成高纵横比的目的，即用于扁平带ñ ≤7个不规则为螺旋带ñ ≥13.对于8≤ ñ≤12时，化合物形成管（BHPB-11除外），并由SANS研究。用成对的管子模型由散射强度确定管子的外径和内径分布。直径由酯链的长度（n）控制，范围从BHPB-8的21到BHPB-12的32 nm（外径）不等。SANS测量还提供了成对管的比例以及最终与这些管共存的非管状物体的比例的估计值。可变温度FTIR和DSC证明，酰胺基团之间的H键参与所有类型的自组装。此外，螺旋带和纳米管的FTIR光谱显示出一个双酯ν CO 带子，而平

  DOI：

  10.1039/c3sm51369f
• 作为产物：
  描述：

  3,5-二苄氧基苯甲酸 在 palladium dihydroxide 偶氮二甲酸二异丙酯 、 氢气 、 溶剂黄146 、 乙酸乙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 生成 octyl 3,5-dihydroxybenzoate
  参考文献：
  名称：

  Lipoxygenase Inhibitory Activity of Octyl Gallate

  摘要：

  Octyl gallate inhibited soybean lipoxygenase-1 (EC 1.13.11.12, type 1) with an IC50 of 1.3 muM. The inhibition of the enzyme by octyl gallate is a slow and reversible reaction without residual activity. The inhibition kinetics analyzed by Lineweaver-Burk plots indicates that octyl gallate is a competitive inhibitor, and the inhibition constant, K-I, was obtained as 0.54 muM. One molecule of octyl gallate scavenged six molecules of 1,1-diphenyl-2-picrylhydrazyl and inhibited autoxidative lipid peroxidation. In addition, octyl gallate was effective in preventing lipid peroxidation.

  DOI：

  10.1021/jf034925k

文献信息

• Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase
  作者：Florin BARLA、Hayato HIGASHIJIMA、Shingo FUNAI、Keiichiro SUGIMOTO、Naoki HARADA、Ryoichi YAMAJI、Tomoyuki FUJITA、Yoshihisa NAKANO、Hiroshi INUI

  DOI：10.1271/bbb.90365

  日期：2009.10.23

  A series of the gallate esters of n-alkanols (C1–C12) was examined to determine their inhibitory activities against hyaluronidase and collagenase. Hexyl, heptyl, octyl, nonyl, and decyl gallates inhibited both hyaluronidase and collagenase, and the most potent inhibitor was octyl gallate against both enzymes. Octyl 3,5-dihydroxybenzoate showed inhibitory effects on hyaluronidase, whereas collagenase was inhibited by octyl 3,4-dihydroxybenzoate.

  我们研究了一系列正构烷醇（C1-C12）的没食子酸酯，以确定它们对透明质酸酶和胶原酶的抑制活性。己基、庚基、辛基、壬基和癸基没食子酸酯对透明质酸酶和胶原酶都有抑制作用，其中没食子酸辛酯对这两种酶的抑制作用最强。3,5-二羟基苯甲酸辛酯对透明质酸酶有抑制作用，而 3,4-二羟基苯甲酸辛酯对胶原酶有抑制作用。
• THERMOPLASTIC POLYMER COMPOSITION
  申请人：Kuraray Co., Ltd.

  公开号：EP1411086A1

  公开（公告）日：2004-04-21

  The present invention provides a thermoplastic polymer composition mainly comprising a block copolymer prepared by extending, with a specific polyurethane component, the polymer chain of a block copolymer, which may be hydrogenated, having a polymer block of an aromatic vinyl compound and a polymer block of a conjugated diene. The thermoplastic polymer composition according to the present invention is excellent in handling properties and melt-moldability, because it shows non-tackiness. By using the thermoplastic polymer composition according to the present invention, a molded article having high qualities can be produced with good productivity.

  本发明提供了一种热塑性聚合物组合物，其主要成分为嵌段共聚物，该嵌段共聚物的聚合物链可以氢化，并具有芳香族乙烯基化合物聚合物嵌段和共轭二烯聚合物嵌段。本发明的热塑性聚合物组合物具有良好的操作性能和熔模性能，因为它没有粘性。通过使用本发明的热塑性聚合物组合物，可以生产出具有高质量和高生产率的模塑制品。
• POLYURETHANE COMPOSITION
  申请人：Kuraray Co., Ltd.

  公开号：EP2208760A1

  公开（公告）日：2010-07-21

  [Problem] Provided are a nonadhesive polyurethane composition, which does not adhere to a molding apparatus and the like, is superior in melt-moldability and adhesion to silicone, and useful as a molded object, a composite molded object or an ink binder, and a molded object, a composite molded object, an ink binder and an ink composition, which are made therefrom. [Solving Means] A polyurethane composition containing' polyurethane (A) containing, in a molecule, a structural unit (I) represented by the following formula (I); wherein R1 and R2 are each a hydrogen atom or a C1-6 alkyl group, in a proportion of 0.1 - 20 mass%, and metal compound (B) selected from an organic Zn compound, an organic Bi compound, an organic Ti compound and an organic Zr compound in a proportion of 0.1 - 2,000 ppm, a molded object comprised of the polyurethane composition, a composite molded object having a polyurethane composition layer and a silicone layer, an ink binder containing the polyurethane composition and an ink composition containing the polyurethane composition.

  [问题]提供了一种不粘附成型装置等的非粘附性聚氨酯组合物，其熔模性和粘附性优于有机硅，可用作成型品、复合成型品或油墨粘合剂，以及由其制成的成型品、复合成型品、油墨粘合剂和油墨组合物。 [解决手段] 一种聚氨酯组合物，其分子中含有'聚氨酯（A），其结构单元（I）由下式（I）表示； 其中 R1 和 R2 各为氢原子或 C1-6 烷基，比例为 0.1 - 20 质量%；金属化合物 (B) 选自有机 Zn 化合物、有机 Bi 化合物、有机 Ti 化合物和有机 Zr 化合物，比例为 0.1 - 2,000 ppm；由该聚氨酯组合物、具有聚氨酯组合物层和硅酮层的复合模制物体、含有该聚氨酯组合物的油墨粘合剂和含有该聚氨酯组合物的油墨组合物组成的模制物体。
• Antifungal activity of octyl gallate: structural criteria and mode of action
  作者：Isao Kubo、Ping Xiao、Ken'ichi Fujita

  DOI：10.1016/s0960-894x(00)00656-9

  日期：2001.2

  Octyl gallate (3,4,5-trihydroxybenzoate) was found to possess antifungal activity against Saccharomyces cerevisiae and Zygosaccharomyces bailii, in addition to its potent antioxidant activity. Catechol moiety is essential to elicit this activity. The primary fungicidal activity of octyl gallate comes from its ability to act as a nonionic surface-active agent (surfactant). The length of the alkyl chain is not a major contributor but plays an important role in eliciting the activity. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Thermoplastic polymer composition
  申请人：——

  公开号：US20040176525A1

  公开（公告）日：2004-09-09

  The present invention provides a thermoplastic polymer composition mainly comprising a block copolymer prepared by extending, with a specific polyurethane component, the polymer chain of a block copolymer, which may be hydrogenated, having a polymer block of an aromatic vinyl compound and a polymer block of a conjugated diene. The thermoplastic polymer composition according to the present invention is excellent in handling properties and melt-moldability, because it shows non-tackiness. By using the thermoplastic polymer composition according to the present invention, a molded article having high qualities can be produced with good productivity.