aegeline B

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: aegeline B
• 英文别名: (Z)-N-[(2S)-2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide
• 化学式: C₁₈H₁₉NO₃
• 分子量: 297.354
• InChiKey: QRFDENJATPJOKG-UUKWBXHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  58.56
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  aegelinoside B 在 水 作用下， 生成 葡萄糖 、 aegeline B
  参考文献：
  名称：

  Phenylethyl cinnamides: A new series of α-glucosidase inhibitors from the leaves of Aegle marmelos

  摘要：

  A series of phenylethyl cinnamides, which included new compounds named anhydromarmeline (1), aegelinosides A (7) and B (8), were isolated from Aegle marmelos leaves as a-glucosidase inhibitors. The structures of new compounds were characterized by spectroscopic data and chemical degradation. Of compounds isolated, anhydroaegeline (2) revealed the most potent inhibitory effect against a-glucosidase with IC50 value of 35.8 mu M. The present result also supports ethnopharmacological use of A. marmelos as a remedy for diabetes mellitus. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.024

文献信息

• Phenylethyl cinnamides: A new series of α-glucosidase inhibitors from the leaves of Aegle marmelos
  作者：Preecha Phuwapraisirisan、Thanchanok Puksasook、Jonkolnee Jong-aramruang、Udom Kokpol

  DOI：10.1016/j.bmcl.2008.08.024

  日期：2008.9

  A series of phenylethyl cinnamides, which included new compounds named anhydromarmeline (1), aegelinosides A (7) and B (8), were isolated from Aegle marmelos leaves as a-glucosidase inhibitors. The structures of new compounds were characterized by spectroscopic data and chemical degradation. Of compounds isolated, anhydroaegeline (2) revealed the most potent inhibitory effect against a-glucosidase with IC50 value of 35.8 mu M. The present result also supports ethnopharmacological use of A. marmelos as a remedy for diabetes mellitus. (C) 2008 Elsevier Ltd. All rights reserved.