4-(2,4-dichlorophenyl)-7,7-dimethyl-1-p-tolyl-3,4,7,8-tetrahydroquinoline-2,5(1H,6H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(2,4-dichlorophenyl)-7,7-dimethyl-1-p-tolyl-3,4,7,8-tetrahydroquinoline-2,5(1H,6H)-dione
• 英文别名: 4-(2,4-dichlorophenyl)-7,7-dimethyl-1-(4-methylphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione；4-(2,4-dichlorophenyl)-7,7-dimethyl-1-(4-methylphenyl)-3,4,6,8-tetrahydroquinoline-2,5-dione
• 化学式: C₂₄H₂₃Cl₂NO₂
• 分子量: 428.358
• InChiKey: WDFVSFCLKSKLFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 5,5-二甲基-3-(4-甲基苯胺基)环己-2-烯-1-酮 、 2,4-二氯苯甲醛 在 1-butyl-3-methylimidazolium Tetrafluoroborate 作用下， 反应 16.0h， 以89%的产率得到4-(2,4-dichlorophenyl)-7,7-dimethyl-1-p-tolyl-3,4,7,8-tetrahydroquinoline-2,5(1H,6H)-dione
  参考文献：
  名称：

  Three-component green synthesis of N-arylquinoline derivatives in ionic liquid [Bmim+][BF4−]: reactions of arylaldehyde, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds

  摘要：

  Three series of N-arylquinoline derivatives were synthesized by the three-component reactions of arylaidehyde, 3-arylamino-5,5-diinethyleyclohex-2-enone, and active methylene compounds including malononitrile, meldrum's acid, and 1,3-indenedione in ionic liquid [bmim(+)][BF4-] at 90 degrees C. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.068

文献信息

• New potential biologically active compounds: Design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation
  作者：Shujiang Tu、Xiaotong Zhu、Jinpeng Zhang、Jianing Xu、Yan Zhang、Qian Wang、Runhong Jia、Bo Jiang、Junyong Zhang、Changsheng Yao

  DOI：10.1016/j.bmcl.2006.03.011

  日期：2006.6

  A series of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones were synthesized through a rapid one-pot four-component reaction under microwave irradiation. The method has the advantages of excellent yields (82-96%) and short reaction time (4-9 min). We provide new series of potential biologically active compounds for biomedical screening. (c) 2006 Elsevier Ltd. All rights reserved.