(E)-N′-(3-(3,4-dimethoxyphenyl)acryloyl)benzohydrazide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-N′-(3-(3,4-dimethoxyphenyl)acryloyl)benzohydrazide
• 英文别名: (e)-N'-(3-(3,4-dimethoxyphenyl)acryloyl)benzohydrazide；N'-[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]benzohydrazide
• 化学式: C₁₈H₁₈N₂O₄
• 分子量: 326.352
• InChiKey: HKQIZUKJKZKKKI-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基肉桂酰氯 在 吡啶 、 hydrazine hydrate 作用下， 以 乙腈 为溶剂， 生成 (E)-N′-(3-(3,4-dimethoxyphenyl)acryloyl)benzohydrazide
  参考文献：
  名称：

  Synthesis of piplartine analogs and preliminary findings on structure–antimicrobial activity relationship

  摘要：

  In this work it is described the synthesis, characterization and antimicrobial and toxicity evaluation of a series of analogs of piplartine, a piperamide found in Piper sp. The compounds structures were confirmed by infrared spectroscopy, H-1, C-13 nuclear magnetic resonance, high resolution mass spectroscopy and were evaluated against strains of Candida spp., Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Derivative 24 was almost four-fold more potent (IC50: 48.83 mu M) and five-fold less toxic (SI > 3) than piplartine (IC50: 189.2 mu M; SI: 0.21) against Candida krusei, as well as two-fold more potent than fluconazole (IC50: 104.48 mu M). This compound was also active against Candida tropicalis at 97.67 mu M. Benzoyl derivative 17 was three-fold more potent (IC50: 85.2 mu M) and more than five-fold less toxic (CC50: 231.71 mu M) than piplartine (IC50: 315.33 mu M and CC50: 41.14 mu M) against Staphylococcus aureus. Given these findings, we have found analogs of piplartine which can be assumed as prototypes for the optimization and the development of new antimicrobial (compounds 24 and 17) agents.

  DOI：

  10.1007/s00044-016-1774-9

文献信息

• Synthesis of piplartine analogs and preliminary findings on structure–antimicrobial activity relationship
  作者：Antonio Maciel Fregnan、Guilherme Andrade Brancaglion、Alexandre Francisco Cerqueira Galvão、Cinara Oliveira D’Sousa Costa、Diogo Rodrigo Magalhães Moreira、Milena Botelho Pereira Soares、Daniel Pereira Bezerra、Naiara Chaves Silva、Stella Maria de Souza Morais、Josidel Conceição Oliver、Amanda Latercia Tranches Dias、Luiz Felipe Leomil Coelho、Diogo Teixeira Carvalho、Danielle Ferreira Dias、Thiago Belarmino de Souza

  DOI：10.1007/s00044-016-1774-9

  日期：2017.3

  In this work it is described the synthesis, characterization and antimicrobial and toxicity evaluation of a series of analogs of piplartine, a piperamide found in Piper sp. The compounds structures were confirmed by infrared spectroscopy, H-1, C-13 nuclear magnetic resonance, high resolution mass spectroscopy and were evaluated against strains of Candida spp., Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Derivative 24 was almost four-fold more potent (IC50: 48.83 mu M) and five-fold less toxic (SI > 3) than piplartine (IC50: 189.2 mu M; SI: 0.21) against Candida krusei, as well as two-fold more potent than fluconazole (IC50: 104.48 mu M). This compound was also active against Candida tropicalis at 97.67 mu M. Benzoyl derivative 17 was three-fold more potent (IC50: 85.2 mu M) and more than five-fold less toxic (CC50: 231.71 mu M) than piplartine (IC50: 315.33 mu M and CC50: 41.14 mu M) against Staphylococcus aureus. Given these findings, we have found analogs of piplartine which can be assumed as prototypes for the optimization and the development of new antimicrobial (compounds 24 and 17) agents.