(2-吡啶-4-基嘧啶-5-基)甲醇 | 729589-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: (2-吡啶-4-基嘧啶-5-基)甲醇
• 英文名称: (2-Pyridin-4-yl-pyrimidin-5-yl)-methanol
• 英文别名: (2-(Pyridin-4-yl) pyrimidin-5-yl) methanol；(2-pyridin-4-ylpyrimidin-5-yl)methanol
• CAS: 729589-44-0
• 化学式: C₁₀H₉N₃O
• 分子量: 187.201
• InChiKey: MGQFJKNFEPAFBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-吡啶-4-基嘧啶-5-基)甲醇 在 palladium dihydroxide sodium azide 、 氢气 、 三苯基膦 作用下， 以 甲醇 、 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 生成 (2-Pyridin-4-ylpyrimidin-5-yl)methanamine
  参考文献：
  名称：

  Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors

  摘要：

  The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.006
• 作为产物：
  描述：

  4-amidinopyridine hydrochloride 在 palladium dihydroxide 氯化亚砜 、 potassium ethoxide 、 氢气 、 二异丁基氢化铝 、 N,N-二异丙基乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 乙醇 、 甲苯 为溶剂， 生成 (2-吡啶-4-基嘧啶-5-基)甲醇
  参考文献：
  名称：

  Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors

  摘要：

  The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.006

文献信息

• [EN] cGAS ANTAGONIST COMPOUNDS<br/>[FR] COMPOSÉS ANTAGONISTES DU CGAS
  申请人：IMMUNE SENSOR LLC

  公开号：WO2017176812A1

  公开（公告）日：2017-10-12

  Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

  揭示了一种新型化合物的化学式（I），这些化合物是cGAS拮抗剂，涉及到这些化合物的制备方法、包含这些化合物的药物组合物，以及它们在医学治疗中的应用。
• cGAS antagonist compounds
  申请人：ImmuneSensor Therapeutics, Inc.

  公开号：US10947206B2

  公开（公告）日：2021-03-16

  Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

  所公开的是作为 cGAS 拮抗剂的新型式 I 化合物、该化合物的制备方法、包含该化合物的药物组合物及其在医学治疗中的用途。
• Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors
  作者：Martina E. Tedder、Zhe Nie、Stephen Margosiak、Shaosong Chu、Victoria A. Feher、Robert Almassy、Krzysztof Appelt、Kraig M. Yager

  DOI：10.1016/j.bmcl.2004.04.006

  日期：2004.6

  The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity. (C) 2004 Elsevier Ltd. All rights reserved.