(2-吡啶基)三氟硼酸钾 | 561328-70-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: (2-吡啶基)三氟硼酸钾
• 中文别名: 吡啶-2-基三氟硼酸钾
• 英文名称: potassium 2-pyridyltrifluoroborate
• 英文别名: potassium pyrido-2-trifluoroborate；potassium pyridine-2-trifluoroborate；Potassium (pyridin-2-yl)trifluoroborate；potassium;trifluoro(pyridin-2-yl)boranuide
• CAS: 561328-70-9
• 化学式: C₅H₄BF₃N*K
• 分子量: 184.998
• InChiKey: VXCPQBPINNXCOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.86
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2933399090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Potassium (pyridin-2-yl)trifluoroborate
Synonyms: Potassium (2-pyridinyl)trifluoroborate

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Potassium (pyridin-2-yl)trifluoroborate
CAS number: 561328-70-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, under −20◦C.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C5H4BF3KN
Molecular weight: 185.0

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  苯胺 、 (2-吡啶基)三氟硼酸钾 在 盐酸 、 sodium nitrite 、 氟硼酸钠 、 palladium diacetate 、 sodium carbonate 作用下， 以 水 为溶剂， 反应 6.17h， 生成 2-苯基吡啶
  参考文献：
  名称：

  钯重氮盐与芳基硅烷和芳基三氟硼酸酯在水中的交叉偶联反应

  摘要：

  在简单的好氧条件下，在室温下于水中将各种芳族重氮鎓盐与ArSi（OR）3和KArBF 3进行Pd催化的交叉偶联反应，得到的产率高至优。官能团的耐受性使这些转化成为传统交叉偶联方法的诱人替代品。此外，该序列也可以在一锅多米诺骨牌过程中进行，省去了中间芳烃重氮盐的分离。

  DOI：

  10.1016/j.tetlet.2013.09.001
• 作为产物：
  描述：

  砒啶-2-硼酸二甲酯 在 potassium hydrogen bifluoride 作用下， 以 乙醚 、 正己烷 、 水 为溶剂， 反应 3.0h， 生成 (2-吡啶基)三氟硼酸钾
  参考文献：
  名称：

  钯催化的芳基三氟硼酸钾和杂芳基三氟硼酸钾的Suzuki-Miyaura交叉偶联反应。

  摘要：

  提出了对Suzuki-Miyaura交叉偶联反应中芳基三氟硼酸钾和杂芳基三氟硼酸钾的反应性的扩展研究。富芳基和电子富集的杂芳基三氟硼酸酯与芳基和活化的杂芳基溴化物的偶联在无配体条件下容易进行。当钝化的芳基和杂芳基三氟硼酸酯与芳基和杂芳基溴化物和氯化物偶联时，PdCl（2）（dppf）.CH（2）Cl（2）的低负载量（0.5-2％）有效催化反应。在任何一种条件下，反应通常可以在露天气氛中进行。

  DOI：

  10.1021/jo0342368

文献信息

• [EN] OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] COMPOSÉS D'OXAZOLIDINONE ET LEURS DÉRIVÉS
  申请人：AMGEN INC

  公开号：WO2013134079A1

  公开（公告）日：2013-09-12

  Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

  式(I)和式(II)的化合物是坦克酶的有用抑制剂。式(I)和式(II)的化合物具有以下结构：其中变量的定义在此提供。
• Nonsymmetrical Bis-Azine Biaryls from Chloroazines: A Strategy Using Phosphorus Ligand-Coupling
  作者：Benjamin T. Boyle、Michael C. Hilton、Andrew McNally

  DOI：10.1021/jacs.9b08504

  日期：2019.9.25

  in demand as these compounds have multiple applications in the chemical sciences and are challenging targets for metal-catalyzed cross-coupling reactions. Most approaches focus on developing new reagents as the formal nucleophilic coupling partner that can function in metal-catalyzed processes. We present an alternative approach using pyridine and diazine phosphines as nucleophilic partners and chloroazines

  需要独特的方法来合成双嗪联芳基化合物，因为这些化合物在化学科学中有多种应用，并且是金属催化交叉偶联反应的挑战性目标。大多数方法侧重于开发新试剂，作为可以在金属催化过程中发挥作用的正式亲核偶联伙伴。我们提出了一种替代方法，使用吡啶和二嗪膦作为亲核伙伴和氯嗪，其中杂联芳键是通过串联 SNAr-磷配体偶联序列形成的。杂芳基膦由氯嗪制备并且是长期稳定的固体。使用这种策略可以从丰富的氯嗪中形成一系列双嗪联芳基化合物，这对于使用传统方法来说是具有挑战性的。
• Palladium-Catalyzed Suzuki Cross-Coupling of 2-Halo-Deazapurines with Potassium Organotrifluoroborate Salts in the Regioselective Synthesis of Imidazo[4,5-b]pyridine Analogues
  作者：Bhaskaran Savitha、Ayyiliath. M. Sajith、M. Nibin Joy、K.K. Abdul Khader、A. Muralidharan、M. Syed Ali Padusha、Yadav D. Bodke

  DOI：10.1071/ch15420

  日期：——

  In this paper, we report the use of potassium organotrifluoroborate salts as nucleophilic organoboron reagents in the Suzuki cross-coupling reactions of 2-halo deazapurines. Regio-isomeric C-2-substituted imidazo[4,5-b]pyridine analogues were synthesized by employing this protocol in good to excellent yields. Whereas aryl and heteroaryl trifluoroborates reacted readily to give the coupled products

  在本文中，我们报告了在三卤代脱氮嘌呤的Suzuki交叉偶联反应中有机三氟硼酸钾盐作为亲核有机硼试剂的用途。通过使用该方案以良好至优异的产率合成了区域异构的C-2-取代的咪唑并[4，5- b ]吡啶类似物。芳基和杂芳基三氟硼酸酯容易反应，以高收率得到偶联产物，而三氟硼酸烷基酯则反应性较低。发现乙酸四丁铵的利用在提高交叉偶联过程的反应速率中起重要作用。另外，在硼酸和有机三氟硼酸钾盐之间进行了比较研究。
• A General Method for Interconversion of Boronic Acid Protecting Groups: Trifluoroborates as Common Intermediates
  作者：Quentin I. Churches、Joel F. Hooper、Craig A. Hutton

  DOI：10.1021/acs.joc.5b00182

  日期：2015.6.5

  interconversion of diverse protected boronic acids, via intermediate organotrifluoroborates. N-Methyliminodiacetyl boronates, which have been hitherto resistant to direct conversion to trifluoroborates, have been shown to undergo fluorolysis at elevated temperatures. Subsequent solvolysis of organotrifluoroborates in the presence of trimethylsilyl chloride and a wide range of bis-nucleophiles enables

  我们已经开发了通过中间有机三氟硼酸酯相互转化各种受保护的硼酸的通用协议。迄今为止已经耐直接转化成三氟硼酸酯的N-甲基亚氨基二乙酰基硼酸酯已经显示出在高温下发生氟化分解。在三甲基甲硅烷基氯和各种双亲核试剂的存在下，有机三氟硼酸酯的随后溶剂分解能够生成多种受保护的硼酸。
• Pd-catalyzed cross-coupling reactions of arenediazonium salts with arylsilanes and aryltrifluoroborates in water
  作者：Kai Cheng、Baoli Zhao、Sai Hu、Xian-Man Zhang、Chenze Qi

  DOI：10.1016/j.tetlet.2013.09.001

  日期：2013.11

  Pd-catalyzed cross-coupling reactions of various arenediazonium salts with ArSi(OR)3 and KArBF3 have been achieved in good to excellent yields under simple aerobic conditions in water at room temperature. The functional group tolerance makes these transformations as attractive alternatives to the traditional cross-coupling approaches. Furthermore, the sequence can also be performed in a one-pot domino

  在简单的好氧条件下，在室温下于水中将各种芳族重氮鎓盐与ArSi（OR）3和KArBF 3进行Pd催化的交叉偶联反应，得到的产率高至优。官能团的耐受性使这些转化成为传统交叉偶联方法的诱人替代品。此外，该序列也可以在一锅多米诺骨牌过程中进行，省去了中间芳烃重氮盐的分离。