(2-甲氧基-4-丙酰基苯氧基)乙酸 | 22637-50-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (2-甲氧基-4-丙酰基苯氧基)乙酸
• 英文名称: (2-Methoxy-4-propionyl-phenoxy)-acetic acid
• 英文别名: (2-Methoxy-4-propionylphenoxy)acetic acid；2-(2-methoxy-4-propanoylphenoxy)acetic acid
• CAS: 22637-50-9
• 化学式: C₁₂H₁₄O₅
• 分子量: 238.24
• InChiKey: ZJIMGRREQHESFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2918990090

反应信息

• 作为产物：
  描述：

  碘乙酸 、 3-甲氧基-4-羟基苯丙酮 在 sodium hydroxide 、 盐酸 作用下， 生成 (2-甲氧基-4-丙酰基苯氧基)乙酸
  参考文献：
  名称：

  Ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit—Potential anti-metastatic drugs

  摘要：

  A series of ethacrynic acid analogues, lacking the alpha,beta-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy groups at the phenyl ring of ethacrynic acid is important in order for the ethacrynic acid analogues to demonstrate an inhibitory effect on the migration. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.144

文献信息

• Ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit—Potential anti-metastatic drugs
  作者：Romy F.J. Janser、Ranjith K. Meka、Zack E. Bryant、Enoch A. Adogla、Elizabeth K. Vogel、Jaimie L. Wharton、Cynthia M. Tilley、Catherine N. Kaminski、Seth L. Ferrey、Severine Van slambrouck、Wim F.A. Steelant、Ingo Janser

  DOI：10.1016/j.bmcl.2010.01.144

  日期：2010.3

  A series of ethacrynic acid analogues, lacking the alpha,beta-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy groups at the phenyl ring of ethacrynic acid is important in order for the ethacrynic acid analogues to demonstrate an inhibitory effect on the migration. (C) 2010 Elsevier Ltd. All rights reserved.