(2S)-2-(十二烷基氨基)丙酸 | 32214-00-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2S)-2-(十二烷基氨基)丙酸
• 英文名称: N-dodecylalanine
• 英文别名: N-Dodecyl-L-alanine；(2S)-2-(dodecylamino)propanoic acid
• CAS: 32214-00-9
• 化学式: C₁₅H₃₁NO₂
• 分子量: 257.417
• InChiKey: WJYAJBDKANFOID-AWEZNQCLSA-N

物化性质

• 熔点：
  103-104 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• 沸点：
  366.7±25.0 °C(Predicted)
• 密度：
  0.919±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2S)-2-(十二烷基氨基)丙酸 、 聚合甲醛 、 氰基硼氢化钠 以55%的产率得到
  参考文献：
  名称：

  GAMA, YASUO;SUZUKI, HIROSHI, J. NAT. CHEM. LAB. IND., 83,(1988) N 3, 109-114

  摘要：

  DOI：
• 作为产物：
  描述：

  L-丙氨酸 、 十二烷醇 在 2,2,2-三氟乙醇 、 (2,4-bis(trimethylsilyl)bicyclo[3.3.0]nona-1,4-dien-3-one)iron acetonitriledicarbonyl 作用下， 反应 24.0h， 以49%的产率得到(2S)-2-(十二烷基氨基)丙酸
  参考文献：
  名称：

  [EN] N-ALKYLATED AMINO ACIDS AND OLIGOPEPTIDES, USES THEREOF AND METHODS FOR PROVIDING THEM.
  [FR] ACIDES AMINÉS N-ALKYLÉS ET OLIGOPEPTIDES, LEURS UTILISATIONS ET LEURS PROCÉDÉS DE PRODUCTION

  摘要：

  该发明涉及两性氨基酸衍生物的合成，特别涉及一种用于对未保护的氨基酸或寡肽底物的N-烷基化的方法，包括将所述未保护的氨基酸或寡肽底物与醇（例如脂肪醇）在均相过渡金属催化剂的存在下反应。

  公开号：

  WO2018178397A1

文献信息

• Polyhydroxyalkanoate-containing structure and manufacturing method thereof
  申请人：Nomoto Tsuyoshi

  公开号：US20050208635A1

  公开（公告）日：2005-09-22

  A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base material surface, synthesizing, on the base material surface, polyhydroxyalkanoate using a 3-hydroxyacyl coenzyme A to become the substrate of the synthase and the synthase and coating at least a part of the base material surface with the synthesized polyhydroxyalkanoate, wherein the synthase contains an amino acid sequence capable of binding to the base material. A polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with a polyhydroxyalkanoate, comprises the base material, a polyhydroxyalkanoate synthase immobilized on the base material surface, and the polyhydroxyalkanoate with which at least a part of the base material surface is coated, wherein the synthase contains an amino acid sequence capable of binding to the base material.

  一种制造含有聚羟基脂肪酸酯结构的方法，该结构的至少一部分基材表面涂覆有聚羟基脂肪酸酯，该方法包括以下步骤：将聚羟基脂肪酸酯合成酶固定在基材表面上，使用3-羟基酰辅酶A作为合成酶的底物，在基材表面上合成聚羟基脂肪酸酯，并将至少一部分基材表面涂覆合成的聚羟基脂肪酸酯，其中合成酶含有能够与基材结合的氨基酸序列。一种含有聚羟基脂肪酸酯结构，该结构的至少一部分基材表面涂覆有聚羟基脂肪酸酯，包括基材、固定在基材表面上的聚羟基脂肪酸酯合成酶和至少一部分基材表面涂覆的聚羟基脂肪酸酯，其中合成酶含有能够与基材结合的氨基酸序列。
• A process for preparing a hydantoin derivative
  申请人：AJINOMOTO CO., INC.

  公开号：EP0131365A1

  公开（公告）日：1985-01-16

  An improved process is disclosed for preparing a hydantoin derivative from a hydrophobic aldehyde or ketone. In the process for preparing a hydantoin derivative by reaction of a hydrophobic aldehyde or ketone with ammonium, cyanide and carbonate ions in water, the reaction is carried out with said hydrophobic aldehyde or ketone emulsified in the presence of a surface-active agent or by vigorous mechanical agitation, whereby the corresponding hydantoin derivative is produced in excellent yields.

  本发明公开了一种用疏水醛或酮制备海因衍生物的改进工艺。在通过疏水性醛或酮与铵、氰化物和碳酸根离子在水中反应制备海因衍生物的工艺中，反应是在表面活性剂存在下或通过剧烈的机械搅拌使所述疏水性醛或酮乳化后进行的，从而以极好的收率制得相应的海因衍生物。
• Percutaneous absorption accelerator for ionic water-soluble medicine
  申请人：SHOWA DENKO KABUSHIKI KAISHA

  公开号：EP0189861A2

  公开（公告）日：1986-08-06

  A percutaneous absorption accelerator for ionic water-soluble medicines comprising at least one member selected from the group consisting of ionic oil-soluble substances and their salts, amphoteric surfactants, and nonionic substances. These substances can effectively and efficiently accelerate the desired percutaneous absorption of ionic water-soluble medicines.

  一种用于离子型水溶性药物的经皮吸收促进剂，由至少一种选自离子型油溶性物质及其盐类、两性表面活性剂和非离子型物质的成员组成。这些物质可以有效和高效地加速离子水溶性药物的预期经皮吸收。
• Electrodeposition coating composition containing a modified epoxy resin having chargeable groups
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0276872A2

  公开（公告）日：1988-08-03

  An anodic electrodeposition composition containing a water-soluble or water-dispersible modified epoxy resin derived from an epoxy resin having two epoxide groups and at least one alcoholic hydroxy group at the terminals and the middle of the resin backbone, respectively. The modified epoxy resin has at least one polymeric side chain block bound to said alcoholic hydroxy group and at least one acid group derived from said terminal epoxide group.

  一种阳极电沉积组合物，含有一种水溶性或水分散性改性环氧树脂，该改性环氧树脂来源于一种环氧树脂，该环氧树脂在树脂骨架的末端和中间分别具有两个环氧基团和至少一个醇羟基团。改性环氧树脂具有至少一个与所述醇羟基结合的聚合物侧链块和至少一个来自所述末端环氧基的酸基。
• Sustained release pesticidal or plant growth regulating composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0646314A1

  公开（公告）日：1995-04-05

  There are discolsed a pesticidal composition containing a water-insoluble alginate, which is prepared by treating a solid composition containing (a) a pesticidally active ingredient which is a pest-controlling active ingredient or a plant growth-regulating active ingredient and (b) an alginic acid or a water-soluble alginate with an aqueous solution containing a divalent or polyvalent cation which can convert said alginic acid or water-soluble alginate into a water-insoluble alginate. Also disclosed is a pesticidal composition containing a water-insoluble alginate, which is prepared by coating a solid substance containing the pesticidally active ingredient with a water-insoluble alginate. The composition of the invention has excellent sustained-release effects of the pesticidally active ingredient.

  本发明公开了一种含有水不溶性藻酸盐的杀虫组合物，其制备方法是将含有(a) 杀虫活性成分（一种害虫控制活性成分或植物生长调节活性成分）和(b) 藻酸或水溶性藻酸盐的固体组合物用含有二价或多价阳离子的水溶液处理，该阳离子可将所述藻酸或水溶性藻酸盐转化为水不溶性藻酸盐。本发明还公开了一种含有水不溶性海藻酸盐的杀虫组合物，其制备方法是将含有杀虫活性成分的固体物质包覆在水不溶性海藻酸盐上。本发明的组合物具有优异的农药活性成分持续释放效果。