trans-1-[3-(4-Acetylphenoxy)propyl]-3,5-dimethylpiperidine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-1-[3-(4-Acetylphenoxy)propyl]-3,5-dimethylpiperidine
• 英文别名: 1-[4-[3-[(3S,5S)-3,5-dimethylpiperidin-1-yl]propoxy]phenyl]ethanone
• 化学式: C₁₈H₂₇NO₂
• 分子量: 289.4
• InChiKey: PYBVHKIENNJVSY-GJZGRUSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  trans-1-[3-(4-Acetylphenoxy)propyl]-3,5-dimethylpiperidine 、 、 甲基溴化镁 在 氯化铵 、 乙酸乙酯 、 水 、 magnesium sulfate 、 silica gel 、 methanol-dichloromethane 、 expected product 、 草酸酯 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以to give 70 mg of trans-1-{3-[4-(1-hydroxy-1-methylethyl)-phenoxy]propyl}-3,5-dimethylpiperidine, oxalate as a pale yellow solid的产率得到trans-1-{3-[4-(1-Hydroxy-1-methylethyl)-phenoxy]propyl}-3,5-dimethylpiperidine
  参考文献：
  名称：

  NOVEL HISTAMINE H3-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS

  摘要：

  本专利申请涉及式(I)的化合物，其中R1和R2与它们所连接的氮原子结合形成单环或双环饱和含氮环; 它们的制备及其用作H3受体配体，用于治疗例如阿尔茨海默病等中枢神经系统疾病。

  公开号：

  US20090111808A1

文献信息

• ENZYME INHIBITORS
  申请人：Thormann Michael

  公开号：US20070244177A1

  公开（公告）日：2007-10-18

  There is dislosed herein compounds of formula (I), wherein: R 1 , R 2 , R 3 , R 4 and R 5 are defined throughout the description and the claims. The compounds of formula (I) are useful for the treatment of neurological diseases and neurodegenerative diseases, e.g. anxiety, depression, Alzheimer's disease etc.

  本文披露了公式（I）的化合物，其中：R1、R2、R3、R4和R5在描述和权利要求中有定义。公式（I）的化合物可用于治疗神经疾病和神经退行性疾病，例如焦虑、抑郁、阿尔茨海默病等。
• Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
  申请人：BIOPROJET

  公开号：EP1717234A1

  公开（公告）日：2006-11-02

  The present patent application concerns compounds of formula (I), with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.

  本专利申请涉及公式（I）的化合物，其中R1和R2与它们所连接的氮原子一起形成一个单环或双环饱和氮含环；它们的制备以及它们作为H3受体配体用于治疗例如阿尔茨海默病等中枢神经系统疾病。
• Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
  申请人：SOCIETE CIVILE BIOPROJET

  公开号：EP0978512A1

  公开（公告）日：2000-02-09

  Compounds of formula (I): and their use for preparing medicaments acting as antagonists at the H3-receptors of histamine.

  式(I)的化合物及其用于制备作为组胺H3受体拮抗剂的药物。
• Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
  申请人：——

  公开号：US20040220225A1

  公开（公告）日：2004-11-04

  Use of a compound of formula (A), wherein: 1 W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用式(A)的化合物，其中：1W是一个残基，当附加在咪唑环的4(5)位时，赋予组合物在组胺H3受体上的拮抗和/或激动活性；R1和R2可以相同也可以不同，分别独立地表示较低的烷基或环烷基，或者与它们所连接的氮原子一起，表示饱和的含氮环(i)、非芳香性不饱和含氮环(ii)、吗啡环或N-取代哌嗪环，用于制备在组胺H3受体上作为拮抗剂和/或激动剂的药物。
• Non-imidazole alkylamines as histamine H3- receptor ligands and their therapeutic applications
  申请人：Schwartz Jean-Charles

  公开号：US20060247223A1

  公开（公告）日：2006-11-02

  Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H 3 -receptors when attached to an imidazole ring in 4(5) position; R 1 and R 2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H 3 -receptors of histamine.

  使用公式（A）中的化合物，其中： W是一个残留物，当附加到咪唑环的4（5）位时，赋予组织胺H3受体的拮抗和/或激动活性； R1和R2可以相同也可以不同，并且独立地表示较低的烷基或环烷基，或者与它们附着的氮原子一起，表示饱和的含氮环（i）如定义，非芳香性不饱和含氮环（ii）如定义，吗啉基或N-取代的哌嗪基，如定义，用于制备作为组织胺H3受体的拮抗剂和/或激动剂的药物。