(E)-4-甲氧基丁烯醛 | 66651-55-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (E)-4-甲氧基丁烯醛
• 英文名称: (E)-4-methoxybutenal
• 英文别名: 4-methoxy-but-2t-enal；(E)-4-methoxy-2-butenal；(E)-4-methoxybut-2-enal
• CAS: 66651-55-6
• 化学式: C₅H₈O₂
• 分子量: 100.117
• InChiKey: RTECOMVXMVKIAE-NSCUHMNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-4-甲氧基丁烯醛 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以85%的产率得到(E)-4-methoxybut-2-en-1-ol
  参考文献：
  名称：

  Electroorganic chemistry. 68. A new method of 1,4-transposition of a carbonyl group

  摘要：

  DOI：

  10.1021/jo00159a042
• 作为产物：
  描述：

  1-acetoxybuta-1,3-diene 在 四乙基对甲苯磺酸铵 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 以76%的产率得到(E)-4-甲氧基丁烯醛
  参考文献：
  名称：

  Electroorganic chemistry. 68. A new method of 1,4-transposition of a carbonyl group

  摘要：

  DOI：

  10.1021/jo00159a042

文献信息

• Compounds and compositions useful as antifungal and antimycobacterial
  申请人：The University of Mississippi

  公开号：US05227383A1

  公开（公告）日：1993-07-13

  New analogs of sampangine and cleistopholine, compositions and methods of preparation thereof, method of treating fungal and mycobacterial infections. The compounds have the general formula: ##STR1## where the R.sub.1, R.sub.2, and R.sub.5 groups are defined herein.

  新的sampangine和cleiSTopholine的类似物，其组成物和制备方法，治疗真菌和分枝杆菌感染的方法。这些化合物具有一般公式：##STR1##其中R.sub.1、R.sub.2和R.sub.5基团在此处被定义。
• Asymmetric Synthesis of β-Alkynyl Aldehydes by Rhodium-Catalyzed Conjugate Alkynylation
  作者：Takahiro Nishimura、Takahiro Sawano、Tamio Hayashi

  DOI：10.1002/anie.200904486

  日期：2009.10.12

  To the point: The rhodium‐catalyzed asymmetric conjugate alkynylation of α,β‐unsaturated aldehydes with triisopropylsilyl acetylene proceeded efficiently in methanol to give the β‐alkynyl aldehydes in high yields with high enantioselectivity (see Scheme).

  关键点是：在甲醇中，铑催化的α，β-不饱和醛与三异丙基甲硅烷基乙炔的不对称共轭炔基化反应以高收率和高对映选择性（见方案）得到β-炔基醛。
• Antimycobacterial method
  申请人：The University of Mississippi

  公开号：US05530004A1

  公开（公告）日：1996-06-25

  New analogs of sampangine and cleistopholine, compositions and methods of preparation thereof, method of treating fungal and mycobacterial infections.

  新的sampangine和cleistopholine类似物，其组合物和制备方法，以及治疗真菌和分枝杆菌感染的方法。
• Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines
  作者：John R. Peterson、Jordan K. Zjawiony、Shihchih Liu、Charles D. Hufford、Alice M. Clark、Robin D. Rogers

  DOI：10.1021/jm00100a012

  日期：1992.10

  Several A- and B-ring-substituted sampangines were synthesized and evaluated for antifungal and antimycobacterial activity against AIDS-related opportunistic infection pathogens. Electrophilic halogenation provided a channel for structural elaboration of the sampangine B-ring at position 4, while the synthesis of A-ring 3-substituted sampangines and benzo[4,5]sampangine (24) were achieved from the corresponding functionalized cleistopholines. Two-dimensional NMR spectroscopy was used to rigorously characterize the A- and B-ring substituent patterns. Structure-activity relationship studies revealed the activity of the sampangines was enhanced by the presence of a substituent at position 3 or by a 4,5-benzo group.
• Baltes,H. et al., Chemische Berichte, 1978, vol. 111, p. 1294 - 1314
  作者：Baltes,H. et al.

  DOI：——

  日期：——