6-fluoro-8-trifluoromethyl-1,4-dihydro-4-oxo-1-methyl-7-[4-(2-chlorophenyl)piperazin-1-yl]quinoline-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-fluoro-8-trifluoromethyl-1,4-dihydro-4-oxo-1-methyl-7-[4-(2-chlorophenyl)piperazin-1-yl]quinoline-3-carboxylic acid
• 英文别名: 7-[4-(2-Chlorophenyl)piperazin-1-yl]-6-fluoro-1-methyl-4-oxo-8-(trifluoromethyl)quinoline-3-carboxylic acid
• 化学式: C₂₂H₁₈ClF₄N₃O₃
• 分子量: 483.85
• InChiKey: DUYVZLTVVNLFQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  64.1
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• REMEDIES OR PREVENTIVES FOR AIDS
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0878194A1

  公开（公告）日：1998-11-18

  The present invention is to provide the combined use of one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor, and an AIDS therapeutic agent or preventive agent containing as its active ingredients one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor.

  本发明提供了一种或两种或两种以上具有抗HIV活性的喹诺酮羧酸与一种或两种或两种以上的逆转录酶抑制剂或HIV蛋白酶抑制剂的联合使用，以及一种包含作为其活性成分的抗HIV活性的喹诺酮羧酸和一种或两种或两种以上的逆转录酶抑制剂或HIV蛋白酶抑制剂的艾滋病治疗剂或预防剂。
• TRIFLUOROMETHYLQUINOLINECARBOXYLIC ACID DERIVATIVE
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0773214A1

  公开（公告）日：1997-05-14

  This invention relates to a 8-trifluoromethylquinolinecaboxylic acid derivative represented by the following formula (I): (wherein R1 represents a lower alkyl group, a halogeno-lower alkyl group or a cycloalkyl group, R2 represents a phenyl group which may be substituted by R0, a 5-membered or 6-membered aromatic heteromonocyclic ring group containing 1 or 2 hetero atoms selected from N, O and S, which may be substituted by R0, or an aromatic heterocyclic fused ring group in which the said aromatic heteromonocyclic ring and a benzene ring are fused, R0 represents a group selected from a halogen, a lower alkyl, a fluorine-substituted lower alkyl, a lower alkoxy or a lower alkylthio, R3 represents hydrogen or a lower alkyl group, and m represents an integer of 2 or 3.) or a pharmaceutically acceptable salt thereof or an ester thereof.

  本发明涉及由下式(I)代表的8-三氟甲基喹啉甲酸衍生物： (其中 R1 代表低级烷基、卤代低级烷基或环烷基，R2 代表可被 R0 取代的苯基、含有 1 或 2 个选自 N、O 和 S 的杂原子的 5 元或 6 元芳香杂环基团（可被 R0.取代）或芳香杂环基团（可被 R0.取代）、R0 代表选自卤素、低级烷基、氟取代的低级烷基、低级烷氧基或低级烷硫基的基团，R3 代表氢或低级烷基，m 代表 2 或 3 的整数。) 或其药学上可接受的盐或其酯。
• US6034086A
  申请人：——

  公开号：US6034086A

  公开（公告）日：2000-03-07