1,1-二氯-3-甲氧基丙烷 | 2806-74-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,1-二氯-3-甲氧基丙烷
• 英文名称: 1,1-Dichloro-3-methoxypropane
• 英文别名: (3,3-dichloro-propyl)-methyl ether；(3,3-Dichlor-propyl)-methyl-aether；1,1-Dichlor-3-methoxy-propan
• CAS: 2806-74-8
• 化学式: C₄H₈Cl₂O
• 分子量: 143.013
• InChiKey: YGSHJAGOTBMQJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1-二氯-3-甲氧基丙烷 、 亚甲基环丙烷 在 sodium hexamethyldisilazane 作用下， 以 正戊烷 为溶剂， 反应 10.0h， 以53%的产率得到1-Chloro-1-(2-methoxyethyl)spiropentane
  参考文献：
  名称：

  Branched triangulanes: general strategy of synthesis

  摘要：

  A general synthetic strategy for the construction of branched triangulanes (BTs) (spirocondensed polycyclopropanes) has been elaborated. The synthetic utility of the method is illustrated by the synthesis of some members of the [5]- and [6]BT families, especially 13a,b and 14. An independent synthesis of the perspirocyclopropanated spiropentane 14 is also presented.

  DOI：

  10.1021/jo00028a054
• 作为产物：
  描述：

  3-甲氧基丙醛 在 吡啶 、 五氯化磷 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 以55%的产率得到1,1-二氯-3-甲氧基丙烷
  参考文献：
  名称：

  Branched triangulanes: general strategy of synthesis

  摘要：

  A general synthetic strategy for the construction of branched triangulanes (BTs) (spirocondensed polycyclopropanes) has been elaborated. The synthetic utility of the method is illustrated by the synthesis of some members of the [5]- and [6]BT families, especially 13a,b and 14. An independent synthesis of the perspirocyclopropanated spiropentane 14 is also presented.

  DOI：

  10.1021/jo00028a054

文献信息

• Potassium channel openers
  申请人：——

  公开号：US20020028836A1

  公开（公告）日：2002-03-07

  Compounds of formula I: 1 are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  公式I的化合物： 1 在治疗通过或用钾通道开放剂预防或改善的疾病中是有用的。还公开了钾通道开放组合物以及在哺乳动物中开放钾通道的方法。
• Aminal Diones as potassium channel openers
  申请人：——

  公开号：US20020147230A1

  公开（公告）日：2002-10-10

  Compounds of formula (I) 1 may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  化合物的化学式（I）可能在治疗由钾通道开放剂预防或改善的疾病中有用。还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
• Aminal diones as potassium channel openers
  申请人：——

  公开号：US20020165264A1

  公开（公告）日：2002-11-07

  Compounds of formula (I) 1 may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  化合物式(I)1可能有助于治疗通过钾通道开放剂预防或改善的疾病。此外，还披露了钾通道开放组合物和在哺乳动物中开放钾通道的方法。
• DE898588
  申请人：——

  公开号：——

  公开（公告）日：——
• POTASSIUM CHANNEL OPENERS
  申请人：Abbott Laboratories

  公开号：EP1198456A2

  公开（公告）日：2002-04-24