1,2-去甲酮 | 37519-31-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,2-去甲酮
• 英文名称: selin-11-en-4α-ol
• 英文别名: 1-[(2R,4aR,8R,8aR)-8-Hydroxy-4a,8-dimethylperhydronaphthalen-2-yl]ethan-1-one；1-[(2R,4aR,8R,8aR)-8-hydroxy-4a,8-dimethyl-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]ethanone
• CAS: 37519-31-6
• 化学式: C₁₄H₂₄O₂
• 分子量: 224.343
• InChiKey: WUXBKEFKDNZEEO-AAVRWANBSA-N

物化性质

• 沸点：
  321.8±25.0 °C(Predicted)
• 密度：
  1.020±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-去甲酮 、 甲基锂 在 盐酸 作用下， 以 乙醚 、 水 为溶剂， 反应 1.0h， 以100%的产率得到柳杉二醇
  参考文献：
  名称：

  Short and efficient hemisynthesis of α-eudesmol and cryptomeridiol

  摘要：

  The aerial part of Dittrichia viscosa yielded two sesquiterpenes, isocostic acid (1) and ilicic acid (2), on multigram scale. These acids are appropriate starting materials for short and facile syntheses of a-eudesmol (5) and cryptomeridiol (6), natural products featuring anti-Alzheimer and anti-spasmodic properties. Compounds 5 and 6 were obtained in three steps in overall yields of 70% and 52%, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.064
• 作为产物：
  描述：

  4-hydroxy-11(13)-eudesmen-12-oic acid 在 氯甲酸乙酯 、 三乙胺 、 sodium azide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.0h， 以52%的产率得到1,2-去甲酮
  参考文献：
  名称：

  Short and efficient hemisynthesis of α-eudesmol and cryptomeridiol

  摘要：

  The aerial part of Dittrichia viscosa yielded two sesquiterpenes, isocostic acid (1) and ilicic acid (2), on multigram scale. These acids are appropriate starting materials for short and facile syntheses of a-eudesmol (5) and cryptomeridiol (6), natural products featuring anti-Alzheimer and anti-spasmodic properties. Compounds 5 and 6 were obtained in three steps in overall yields of 70% and 52%, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.064

文献信息

• Short and efficient hemisynthesis of α-eudesmol and cryptomeridiol
  作者：Mohamed Tebbaa、Ahmed El Hakmaoui、Ahmed Benharref、Mohamed Akssira

  DOI：10.1016/j.tetlet.2011.05.064

  日期：2011.7

  The aerial part of Dittrichia viscosa yielded two sesquiterpenes, isocostic acid (1) and ilicic acid (2), on multigram scale. These acids are appropriate starting materials for short and facile syntheses of a-eudesmol (5) and cryptomeridiol (6), natural products featuring anti-Alzheimer and anti-spasmodic properties. Compounds 5 and 6 were obtained in three steps in overall yields of 70% and 52%, respectively. (C) 2011 Elsevier Ltd. All rights reserved.