1,5-二甲基二环[3.3.0]辛烷-3,7-二酮 | 53731-21-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,5-二甲基二环[3.3.0]辛烷-3,7-二酮
• 英文名称: 1,5-Dimethyl-bicyclo<3.3.0>octan-3,7-dion
• 英文别名: cis-1,5-Dimethylbicyclo[3.3.0]octane-3,7-dione；3a,6a-dimethyl-1,3,4,6-tetrahydropentalene-2,5-dione
• CAS: 53731-21-8
• 化学式: C₁₀H₁₄O₂
• mdl: MFCD00227813
• 分子量: 166.22
• InChiKey: KGZWVKASYOPUET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2914399090

反应信息

• 作为反应物：
  描述：

  1,5-二甲基二环[3.3.0]辛烷-3,7-二酮 在 lithium aluminium tetrahydride 作用下， 生成 1,5-Dimethylbicyclo<3.3.0>octa-2,6-dien
  参考文献：
  名称：

  Mechanistic alternative for the thermal antara-antara Cope rearrangements of bicyclo[3.2.0]hepta-2,6-dienes and bicyclo[4.2.0]octa-2,7-dienes

  摘要：

  DOI：

  10.1021/ja00745a026
• 作为产物：
  描述：

  1,5-Dimethyl-3,7-dioxo-tetracyclo<3.3.0.0^2,8.0^4,6>octan-2,4,6,8-tetracarbonsaeuretetramethylester 在 溶剂黄146 、 锌 作用下， 生成 1,5-二甲基二环[3.3.0]辛烷-3,7-二酮
  参考文献：
  名称：

  Gompper, Rudolf; Schwarzensteiner, Marie-Luise, Angewandte Chemie, 1982, vol. 94, # 6, p. 447 - 448

  摘要：

  DOI：

文献信息

• [EN] THIENOPYRIMIDINE DERIVATIVE AND USE THEREOF IN MEDICINE<br/>[FR] DÉRIVÉ DE THIÉNOPYRIMIDINE ET SON UTILISATION EN MÉDECINE
  申请人：SUNSHINE LAKE PHARMA CO LTD

  公开号：WO2018133858A1

  公开（公告）日：2018-07-26

  The present invention relates to a thienopyrimidine derivative and use thereof in medicine, and also to a pharmaceutical composition containing the compound. The compound or pharmaceutical composition is used for inhibiting acetyl-CoA carboxylase (ACC). The present invention also relates to a method of preparing such compound and pharmaceutical composition, as well as their use in the treatment or prevention of diseases regulated by acetyl-CoA carboxylase in mammals, especially in humans.

  本发明涉及一种噻吡嘧啶衍生物及其在医学上的用途，以及含有该化合物的药物组合物。该化合物或药物组合物用于抑制乙酰辅酶A羧化酶（ACC）。本发明还涉及一种制备该化合物和药物组合物的方法，以及它们在哺乳动物，特别是人类中治疗或预防由乙酰辅酶A羧化酶调节的疾病的用途。
• Triphenylmethyldifluoramine: a stable reagent for the synthesis of gem-bis(difluoramines)
  作者：G. K. Surya Prakash、Markus Etzkorn、George A. Olah、Karl O. Christe、Stefan Schneider、Ashwani Vij

  DOI：10.1039/b203811k

  日期：——

  The conversion of ketones into geminal bis(difluoramines) can be achieved under mild two-phase reaction conditions by employing triphenylmethyldifluoramine as an in situ source of difluoramine.

  通过使用三苯基甲基二氟胺作为二氟胺的原位源，可以在温和的两相反应条件下将酮转化为双（双氟胺）。
• Cycloaddition von N-phenyltriazolindion an 1,5-dialkyl substituierte semibullvalene
  作者：R. Askani、R. Kirsten、B. Dugall

  DOI：10.1016/0040-4020(81)80010-5

  日期：1981.1

  Starting from bicyclo[3.3.0]octa-3,7-diones, several 3- and 7-substituted semibullvalenes were prepared. Cycloaddition of N-phenyltriazolindione to some of these semibullvalenes lead with rearrangement of the carbon skeleton to dihydrodiazatriquinacenes. Deazoniation of the diazatriquinacenes obtained from the cycloadducts above occurred at 80° to semibullvalenes.

  从双环[3.3.0]八-3，7-二酮开始，制备了几种3-和7-取代的半牛戊烯。N-苯基三唑啉二酮与这些半布尔戊烯中的一些环加成导致碳骨架重排成二氢二氮杂三喹并酮。由以上环加合物获得的二氮杂三喹并酮在80°发生脱氮重氮反应。
• Separation, Storage, and Catalytic Conversion of Fluids Using ITQ-55
  申请人：Corcoran, JR. Edward W.

  公开号：US20160009618A1

  公开（公告）日：2016-01-14

  This invention refers to a microporous crystalline material of zeolitic nature that has, in its calcined state and in the absence of defects in its crystalline matrix manifested by the presence of silanols, the empirical formula x (M 1/n XO 2 ): y YO 2 :g GeO 2 :(1− g )SiO2 in which M is selected between H + , at least one inorganic cation of charge +n, and a mixture of both, X is at least one chemical element of oxidation state +3, Y is at least one chemical element with oxidation state +4 different from Si, x takes a value between 0 and 0.2, both included, y takes a value between 0 and 0.1, both included, g takes a value between 0 and 0.5, both included that has been denoted ITQ-55, as well as a method for its preparation. This invention also relates to uses of the crystalline material of zeolitic nature for adsorption of fluid components, membrane separation of fluid components, storage of fluid components, and catalysis of various conversion reactions.

  这项发明涉及一种微孔晶体性质的沸石类材料，其在经过煅烧处理且在晶体基质中没有缺陷的情况下（通过硅醇的存在来表现），其经验公式为x(M1/nXO2):yYO2:gGeO2:(1−g)SiO2，其中M在H+、至少一个+ n电荷的无机阳离子或两者的混合物中选择，X至少是+3氧化态的一种化学元素，Y至少是+4氧化态与Si不同的一种化学元素，x取值在0和0.2之间（包括0和0.2），y取值在0和0.1之间（包括0和0.1），g取值在0和0.5之间（包括0和0.5），该材料被标记为ITQ-55，以及其制备方法。这项发明还涉及沸石类晶体材料用于吸附流体成分、膜分离流体成分、存储流体成分和催化各种转化反应的用途。
• Photoresist monomer having spiro cyclic ketal group, polymer thereof and photoresist composition including the same
  申请人：DONGJIN SEMICHEM CO., LTD

  公开号：EP1637928A2

  公开（公告）日：2006-03-22

  A photoresist polymer having a spiro cyclic ketal group, and a photoresist composition including the same are disclosed. The photoresist polymer and the photoresist composition can improve the resolution and the process margin due to its low activation energy of the deprotection reaction of the spiro cyclic ketal group, and can produce fine photoresist patterns due to its low PEB(Post Exposure Baking) temperature sensitivity.

  本发明公开了一种具有螺环酮基的光致抗蚀剂聚合物和一种包括该聚合物的光致抗蚀剂组合物。这种光刻胶聚合物和光刻胶组合物由于螺环缩酮基脱保护反应的活化能低，因此可以提高分辨率和加工余量，并且由于其较低的 PEB（曝光后烘烤）温度敏感性，可以产生精细的光刻胶图案。