1-(2-氟-5-硝基苯基)-N-甲基-N-(1-甲基丙基)-3-异喹啉甲酰胺 | 107257-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-(2-氟-5-硝基苯基)-N-甲基-N-(1-甲基丙基)-3-异喹啉甲酰胺
• 英文名称: N-butan-2-yl-1-(2-fluoro-5-nitrophenyl)-N-methylisoquinoline-3-carboxamide
• CAS: 107257-28-3
• 化学式: C21H20FN3O3
• 分子量: 381.4
• InChiKey: GXXKDYZSBGOJQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  79
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Treatment of diseases involving cyst formation with combinations comprising a PTBR agonist
  申请人：SCIOS INC.

  公开号：EP1607744A2

  公开（公告）日：2005-12-21

  The invention concerns the use of ligands of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of diseases involving cyst formation and in particular polycystic kidney disease. The invention further concerns the treatment of hypertension accompanying polycystic kidney disease, and pharmaceutical compositions and articles of manufacture for the treatment of diagnosis of the target disease or condition.

  本发明涉及外周型苯并二氮杂卓受体（PTBR）配体在诊断和治疗涉及囊肿形成的疾病，特别是多囊肾疾病中的应用。本发明还涉及伴随多囊肾病的高血压的治疗，以及用于治疗诊断目标疾病或病症的药物组合物和制造品。
• THERAPEUTIC AGENT FOR NEUROPATHIC PAIN
  申请人：Japan Science and Technology Agency

  公开号：EP1878443A1

  公开（公告）日：2008-01-16

  The present invention provides a therapeutic agent for neuropathic pain having an excellent treating effect on neuropathic pain, which is an intractable disorder. More specifically, the present invention provides a therapeutic agent for neuropathic pain, comprising a peripheral benzodiazepine receptor antagonist (especially, PK11195) as an active ingredient; a pharmaceutical composition for treating neuropathic pain, comprising a peripheral benzodiazepine receptor antagonist as an active ingredient; a method for treating neuropathic pain using a peripheral benzodiazepine receptor antagonist; and the like.

  本发明提供了一种神经病理性疼痛治疗剂，它对神经病理性疼痛这种难治性疾病具有极佳的治疗效果。更具体地说，本发明提供了一种治疗神经病理性疼痛的药物，它包含外周苯并二氮杂卓受体拮抗剂（特别是PK11195）作为活性成分；一种治疗神经病理性疼痛的药物组合物，它包含外周苯并二氮杂卓受体拮抗剂作为活性成分；一种使用外周苯并二氮杂卓受体拮抗剂治疗神经病理性疼痛的方法；以及类似的药物。
• Treatment of diseases involving cyst formation
  申请人：——

  公开号：US20030008864A1

  公开（公告）日：2003-01-09

  The invention concerns the use of ligands of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of diseases involving cyst formation and in particular polycystic kidney disease. The invention further concerns the treatment of hypertension accompanying polycystic kidney disease, and pharmaceutical compositions and articles of manufacture for the treatment or diagnosis of the target disease or condition.

  本发明涉及外周型苯并二氮杂卓受体（PTBR）配体在诊断和治疗涉及囊肿形成的疾病，特别是多囊肾疾病中的应用。本发明还涉及伴随多囊肾病的高血压的治疗，以及用于治疗或诊断目标疾病或病症的药物组合物和制造品。
• Agonists and antagonists of peripheral-type benzodiazepine receptors
  申请人：——

  公开号：US20030032637A1

  公开（公告）日：2003-02-13

  The invention concerns the use of agonists and antagonists of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of cardiac hypertrophy and other circulatory conditions. The invention specifically concerns the use of PTBR antagonists in the prevention or treatment of decompensated cardiac hypertrophy and, eventually, heart failure. The invention also concerns the use of PTBR agonists in the management of conditions calling for increased blood flow or cardiac output, including injury or functional compromise of the heart, increased demand for physical exercise, or an acquired or inherited predisposition to cardiac contractile disfunction. Pharmaceutical compositions for the treatment of such conditions and screening methods to identify PTBR agonists and antagonists are also included.

  本发明涉及外周型苯并二氮杂卓受体（PTBR）的激动剂和拮抗剂在诊断和治疗心脏肥大和其他循环系统疾病中的应用。本发明特别涉及 PTBR 拮抗剂在预防或治疗失代偿性心脏肥大以及最终的心力衰竭中的应用。本发明还涉及 PTBR 激动剂在治疗需要增加血流量或心输出量的病症中的应用，包括心脏损伤或功能受损、体育锻炼需求增加或获得性或遗传性心脏收缩功能障碍。此外，还包括用于治疗此类病症的药物组合物以及鉴定 PTBR 激动剂和拮抗剂的筛选方法。
• USE OF PERIPHERAL-TYPE BENZODIAZEPINE SITES FOR TREATMENT OF CNS TRAUMA OR DISEASE
  申请人：COCENSYS, INC.

  公开号：EP0616532A1

  公开（公告）日：1994-09-28