镁离子载体 VII | 156210-12-7

• 物质功能分类: 分析化学 - 分析试剂 - 常用分析试剂
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 镁离子载体 VII
• 中文别名: 4,13-[双(N-金刚烷基氨基甲酰基)乙酰基]-1,7,10,16-四氧-4,13-二氮环十八烷；镁离子载体VII
• 英文名称: 4,13--1,7,10,16-tetraoxa-4,13-diazacyclooctadecane
• 英文别名: Magnesium ionophore VII；N-(1-adamantyl)-3-[16-[3-(1-adamantylamino)-3-oxopropanoyl]-1,4,10,13-tetraoxa-7,16-diazacyclooctadec-7-yl]-3-oxopropanamide
• CAS: 156210-12-7
• 化学式: C₃₈H₆₀N₄O₈
• 分子量: 700.916
• InChiKey: IPVOJCDBVJUPRP-UHFFFAOYSA-N

物化性质

• 熔点：
  85-90 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  50
• 可旋转键数：
  6
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  N-Adamantan-1-yl-malonamic acid methyl ester 在 lithium hydroxide 、 phosphinic chloride 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 39.0h， 生成 镁离子载体 VII
  参考文献：
  名称：

  Design and Synthesis of Calcium and Magnesium Ionophores Based on Double-Armed Diazacrown Ether Compounds and Their Application to an Ion Sensing Component for an Ion-Selective Electrode

  摘要：

  The double-armed diazacrown ethers, which have a base diazacrown ether ring with two diamide-type side chains, were designed and synthesized on the basis of the proposed molecular model for the novel neutral Ca2+ and Mg2+ ionophores. The potentiometric ion-selective electrodes were prepared with over 20 kinds of systematically synthesized diazacrown ether derivatives. The relationship between the molecular structures of the ionophores and the ion selectivities was fully discussed. The electrodes based on the 21- and 18-membered diazacrown ether derivatives possessing a glycolic diamide and malonic diamide in their side chains (K23E1 and K22B5) exhibited excellent Ca2+ and Mg2+ selectivities, respectively. The ion-selectivity features of the novel Ca2+ and Mg2+ ionophores supply important structural information about the design of host molecules for alkaline earth metal cations.

  DOI：

  10.1021/ac00098a016

文献信息

• IMPROVED MAGNESIUM ION SELECTIVE MEMBRANES
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：US20180024088A1

  公开（公告）日：2018-01-25

  The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilcity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.
• MAGNESIUM ION SELECTIVE MEMBRANES
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：US20210164931A1

  公开（公告）日：2021-06-03

  The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilcity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.
• Design and Synthesis of Calcium and Magnesium Ionophores Based on Double-Armed Diazacrown Ether Compounds and Their Application to an Ion Sensing Component for an Ion-Selective Electrode
  作者：Koji. Suzuki、Kazuhiko. Watanabe、Yukihiro. Matsumoto、Mitsuru. Kobayashi、Sayaka. Sato、Dwi. Siswanta、Hideaki. Hisamoto

  DOI：10.1021/ac00098a016

  日期：1995.1.15

  The double-armed diazacrown ethers, which have a base diazacrown ether ring with two diamide-type side chains, were designed and synthesized on the basis of the proposed molecular model for the novel neutral Ca2+ and Mg2+ ionophores. The potentiometric ion-selective electrodes were prepared with over 20 kinds of systematically synthesized diazacrown ether derivatives. The relationship between the molecular structures of the ionophores and the ion selectivities was fully discussed. The electrodes based on the 21- and 18-membered diazacrown ether derivatives possessing a glycolic diamide and malonic diamide in their side chains (K23E1 and K22B5) exhibited excellent Ca2+ and Mg2+ selectivities, respectively. The ion-selectivity features of the novel Ca2+ and Mg2+ ionophores supply important structural information about the design of host molecules for alkaline earth metal cations.