1-(4-甲基-1(4H)-喹啉基)乙酮 | 634891-63-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 1-(4-甲基-1(4H)-喹啉基)乙酮
• 英文名称: 1-acetyl-1,4-dihydro-4-methylquinoline
• 英文别名: 1-(4-Methylquinolin-1(4H)-yl)ethanone；1-(4-methyl-4H-quinolin-1-yl)ethanone
• CAS: 634891-63-7
• 化学式: C₁₂H₁₃NO
• 分子量: 187.241
• InChiKey: BVJLFGCAKSYHFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-甲基-1(4H)-喹啉基)乙酮 在 吡啶 作用下， 以 1,4-二氧六环 、 高氯酸 为溶剂， 反应 24.0h， 生成 3-(2,5-diacetoxyphenyl)-4-methylquinoline
  参考文献：
  名称：

  3-Hydroquinolylquinolines and Bisquinolyl-annelated Oxepin as Unexpected Products from the Reaction of p-Benzoquinone and N-Acetyl-1,4-dihydroquinolines

  摘要：

  4-Substituted N-acyl-1,4-dihydroquinolines (1a, b) have been yielded by regioselective 4-arylation/alkylation via quinolinium intermediates. Acid-catalysed reaction of la, b with p-benzoquinone leads to unexpected 3-hydroquinolylquinolines (5a, b). The structure of compounds (5a, b) has been confirmed by spectroscopical data and additionally by formation of both O-acetyl derivatives (7a, b). Bisquinolyl-annelated oxcpin (9a) was found as side product. Formation and stereochemistry of the spectroscopically characterized compound (9a) are discussed.

  DOI：

  10.3987/com-03-9817
• 作为产物：
  描述：

  喹啉 、 甲基氯化镁 、 乙酰氯 在 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以80%的产率得到1-(4-甲基-1(4H)-喹啉基)乙酮
  参考文献：
  名称：

  3-Hydroquinolylquinolines and Bisquinolyl-annelated Oxepin as Unexpected Products from the Reaction of p-Benzoquinone and N-Acetyl-1,4-dihydroquinolines

  摘要：

  4-Substituted N-acyl-1,4-dihydroquinolines (1a, b) have been yielded by regioselective 4-arylation/alkylation via quinolinium intermediates. Acid-catalysed reaction of la, b with p-benzoquinone leads to unexpected 3-hydroquinolylquinolines (5a, b). The structure of compounds (5a, b) has been confirmed by spectroscopical data and additionally by formation of both O-acetyl derivatives (7a, b). Bisquinolyl-annelated oxcpin (9a) was found as side product. Formation and stereochemistry of the spectroscopically characterized compound (9a) are discussed.

  DOI：

  10.3987/com-03-9817

文献信息

• 3-Hydroquinolylquinolines and Bisquinolyl-annelated Oxepin as Unexpected Products from the Reaction of p-Benzoquinone and N-Acetyl-1,4-dihydroquinolines
  作者：Andreas Hilgeroth、Burkhardt Voigt

  DOI：10.3987/com-03-9817

  日期：——

  4-Substituted N-acyl-1,4-dihydroquinolines (1a, b) have been yielded by regioselective 4-arylation/alkylation via quinolinium intermediates. Acid-catalysed reaction of la, b with p-benzoquinone leads to unexpected 3-hydroquinolylquinolines (5a, b). The structure of compounds (5a, b) has been confirmed by spectroscopical data and additionally by formation of both O-acetyl derivatives (7a, b). Bisquinolyl-annelated oxcpin (9a) was found as side product. Formation and stereochemistry of the spectroscopically characterized compound (9a) are discussed.