1-(6-甲氧基吡啶-3-基)环丙胺 | 1060806-98-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(6-甲氧基吡啶-3-基)环丙胺
• 英文名称: 1-(6-methoxypyridin-3-yl)cyclopropanamine
• 英文别名: 1-(6-methoxypyridin-3-yl)cyclopropan-1-amine
• CAS: 1060806-98-5
• 化学式: C₉H₁₂N₂O
• 分子量: 164.207
• InChiKey: NLCVUPUPJBMTQU-UHFFFAOYSA-N

物化性质

• 沸点：
  259.4±35.0 °C(Predicted)
• 密度：
  1.167±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-甲氧基烟腈 、 乙基溴化镁 在 titanium(IV) tetraethanolate 作用下， 以 四氢呋喃 为溶剂， 生成 1-(6-甲氧基吡啶-3-基)环丙胺
  参考文献：
  名称：

  [EN] ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  [FR] MODULATEURS ALLOSTÉRIQUES DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE

  摘要：

  The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.

  公开号：

  WO2023049058A1

文献信息

• [EN] ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS<br/>[FR] MODULATEURS ALLOSTÉRIQUES DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE
  申请人：[en]MERCK SHARP & DOHME LLC

  公开号：WO2023049058A1

  公开（公告）日：2023-03-30

  The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.