Synthesis of novel 1,2,3-triazolyl nucleoside analogues bearing uracil, 6-methyluracil, 3,6-dimethyluracil, thymine, and quinazoline-2,4-dione moieties
作者:Olga V. Andreeva、Maya G. Belenok、Liliya F. Saifina、Marina M. Shulaeva、Alexey B. Dobrynin、Radmila R. Sharipova、Alexandra D. Voloshina、Alina F. Saifina、Aidar T. Gubaidullin、Bulat I. Khairutdinov、Yuriy F. Zuev、Vyacheslav E. Semenov、Vladimir E. Kataev
DOI:10.1016/j.tetlet.2019.151276
日期:2019.11
A series of novel 1,2,3-triazolyl nucleoside analogues was synthesized via the CuAAC reaction of N1-alkynyl uracil, 6-methyluracil, 3,6-dimethyl uracil, thymine and quinazolin-2,4-dione with protected azido β-D-ribofuranose. The obtained compounds differ in both the nature of the pyrimidine-2,4-dione fragment and the length of the polymethylene linker connecting it with the β-D-ribofuranosyl-1,2,3-triazol-4-yl
通过N 1-炔基尿嘧啶,6-甲基尿嘧啶,3,6-二甲基尿嘧啶,胸腺嘧啶和喹唑啉-2,4-二酮与受保护的叠氮基β的CuAAC反应合成了一系列新颖的1,2,3-三唑基核苷类似物- d -ribofuranose。所获得的化合物在嘧啶-2,4-二酮片段的性质和将其与β- D-呋喃呋喃糖基-1,2,3-三唑-4-基部分连接的多亚甲基接头的长度上都不同。1,2,3-triazolyl核苷类似物的体外细胞毒性进行了评估。