1-丙基二氯化磷 | 4708-04-7

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 1-丙基二氯化磷
• 中文别名: 丙基磷酰二氯；丙基膦酰二氯
• 英文名称: propylphosphonic dichloride
• 英文别名: n-propylphosphonic dichloride；1-dichlorophosphorylpropane
• CAS: 4708-04-7
• 化学式: C₃H₇Cl₂OP
• 分子量: 160.968
• InChiKey: CWMQAFZROJAZQS-UHFFFAOYSA-N

物化性质

• 沸点：
  88-90 °C50 mm Hg(lit.)
• 密度：
  1.29 g/mL at 25 °C(lit.)
• 闪点：
  >230 °F
• 稳定性/保质期：
  在常温常压下保持稳定。

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险等级：
  8
• 危险品标志：
  T
• 安全说明：
  S23,S26,S36/37/39,S45
• 危险类别码：
  R23/24/25
• WGK Germany：
  3
• 危险品运输编号：
  UN 3265 8/PG 2
• 包装等级：
  II
• 危险类别：
  8
• 储存条件：
  常温、避光、通风干燥处，密封保存。

SDS

Name:	Propyl phosphonic dichloride Material Safety Data Sheet
Synonym:
CAS:	4708-04-7

Section 1 - Chemical Product MSDS Name:Propyl phosphonic dichloride Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
4708-04-7	Propyl phosphonic dichloride		225-195-1

Hazard Symbols: C
Risk Phrases: 20/21/22 34

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed. Causes burns.Moisture sensitive.Corrosive.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Harmful if absorbed through the skin. Causes skin burns.
Ingestion:
Harmful if swallowed. May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns.
Inhalation:
Harmful if inhaled. May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed.
Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide. DO NOT USE WATER! Do NOT get water inside containers.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Do not get water inside containers.

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Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Use with adequate ventilation. Do not allow contact with water. Use only in a chemical fume hood. Discard contaminated shoes. Keep from contact with moist air and steam.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store in a tightly closed container. Keep under a nitrogen blanket.
Corrosives area. Store protected from moisture.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 4708-04-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin. Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Clear liquid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 88 - 90 deg C @ 50.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: > 110 deg C (> 230.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 1.2900g/cm3
Molecular Formula: CH3CH2CH2P(O)Cl2
Molecular Weight: 160.97

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, moisture, exposure to moist air or water.
Incompatibilities with Other Materials:
Not available.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, oxides of phosphorus, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 4708-04-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Propyl phosphonic dichloride - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE LIQUID, TOXIC, N.O.S.*
Hazard Class: 8 (6.1)
UN Number: 2922
Packing Group: II
IMO
Shipping Name: CORROSIVE LIQUID, TOXIC, N.O.S.
Hazard Class: 8 (6.1)
UN Number: 2922
Packing Group: II
RID/ADR
Shipping Name: CORROSIVE LIQUID, TOXIC, N.O.S.
Hazard Class: 8 (6.1)
UN Number: 2922
Packing group: II

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 25 Avoid contact with eyes.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 4708-04-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 4708-04-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 4708-04-7 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  1-丙基二氯化磷 在 水 作用下， 以100%的产率得到1-丙基磷酸酐
  参考文献：
  名称：

  Wissmann, Hans; Kleiner, Hanss-Jerg, Angewandte Chemie, 1980, vol. 92, # 2, p. 129 - 130

  摘要：

  DOI：
• 作为产物：
  描述：

  丙基膦酸 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以90%的产率得到1-丙基二氯化磷
  参考文献：
  名称：

  一种环状丙基膦酸酐的制备方法

  摘要：

  本发明属于有机合成技术领域，尤其涉及一种环状丙基膦酸酐的制备方法，以丙基膦酸和醋酸酐为反应物制得丙基焦膦酸，以丙基膦酸和氯化亚砜为反应物制得丙基膦酰氯，将丙基焦膦酸与丙基膦酰氯进一步反应制得环状丙基膦酸酐。本发明制备得到的环状丙基膦酸酐的反应收率高，总收率高达68‑72％，成本低，纯度高，滴定纯度大于99.5％，游离酸含量小于100ppm，多聚体含量低，能够满足锂电池添加剂的使用。本发明的制备方法简单，安全环保高效，原料廉价易得，市场前景广阔，适合规模化生产。

  公开号：

  CN107011384B

文献信息

• The Mechanism of Thionyl Chloride Reaction with Dialkyl Alkylphosphonothionate Using 31 P NMR
  作者：Purnanand、P. D. Shakya、Shefali Saxena、M. Sharma、Basant Lal

  DOI：10.1080/10426500211715

  日期：2002.5.1

  Based on 31 P NMR studies of thionyl chloride reaction with dialkyl alkylphosphonothionates, a method for preparation of alkylphosphonic dichloride has been investigated. A mechanism via intermediacy of ester chloride is suggested.

  基于亚硫酰氯与二烷基烷基膦硫酸酯反应的 31 P NMR 研究，研究了烷基膦酰二氯的制备方法。提出了一种通过氯化酯中介的机制。
• 含磷氧键结构的湾位有机膦桥联苝酰亚胺及其制备方法
  申请人：西南科技大学

  公开号：CN107936060A

  公开（公告）日：2018-04-20

  本发明提供了一种含磷氧键结构的湾位有机膦桥联苝酰亚胺及其制备方法。所述苝酰亚胺的结构式为所述制备方法包括将四溴苝四羧酸二酐加入溶剂中，搅拌的同时，加入伯胺类化合物，在惰性气体下加热反应，冷却后除去溶剂，提纯，得到四溴苝酰亚胺化合物，然后溶解后进行无水无氧处理，降温后加入正丁基锂溶液，反应后加入含磷酰二氯化合物，经过溶解，洗涤，干燥，提纯处理，得到含磷氧键结构的湾位有机膦桥联苝酰亚胺。本发明的苝酰亚胺在常规有机溶剂中具有较大的溶解度，制备方法简单，产率高，易于实现。
• 含氮磷一元醇或多元醇及其制备方法
  申请人：四川大学

  公开号：CN107964025B

  公开（公告）日：2020-05-29

  本发明提供含氮磷一元醇或多元醇及其制备方法，其分子结构中同时含有氮和磷元素，制备方法是将卤代氧化磷与含羟基丙烯酸酯、胺中和剂反应合成，将反应产物过滤，洗涤，萃取，烘干得到含烯丙基磷酸酯，将含烯丙基磷酸酯再与羟基胺反应，将反应产物烘干，即得含氮磷一元醇或多元醇，其羟基数可通过对卤代氧化磷和羟基胺的选择进行控制。本发明产品具有含羟基数可控，残炭率高，稳定性好的特点，其制备方法具有工艺简单，合成效率高的特点。
• N-heteroaryl substituted derivatives of propanamide useful in the
  申请人：Zambon Group S.p.A.

  公开号：US05438046A1

  公开（公告）日：1995-08-01

  Compounds of formula ##STR1## wherein Y, R.sub.1, R.sub.2, Het, X and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active ingredients are described. The compounds of formula I are useful in the treatment of cardiovascular diseases.

  式##STR1##中的化合物，其中Y、R.sub.1、R.sub.2、Het、X和n的含义如描述中所述，描述了它们的制备过程以及包含它们作为活性成分的药物组合物。式I的化合物在治疗心血管疾病方面是有用的。
• Fluorination of organodichlorophosphorus compounds with sodium hexafluorosilicate, Part 1 1a
  作者：Omar Farooq

  DOI：10.1039/a800243f

  日期：——

  Sodium hexafluorosilicate was used as a source of fluoride ion for nucleophilic fluorination of some selected organodichlorophosphorus compounds in the presence and absence of a multifunctional ethereal solvent, giving fluoro derivatives in low to moderate yields.

  六氟硅酸钠被用作氟离子的来源，在多官能团乙醚溶剂的存在与不存在条件下，对一些选定的有机二氯膦化合物进行亲核氟化反应，以低至中等的产率得到了氟代衍生物。

表征谱图