1-乙基-2-甲基溴化吡啶 | 32353-50-7

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 1-乙基-2-甲基溴化吡啶
• 英文名称: N-ethyl-2-methylpyridinium bromide
• 英文别名: 1-Ethyl-2-methylpyridinium bromide；1-ethyl-2-methylpyridin-1-ium;bromide
• CAS: 32353-50-7
• 化学式: Br*C₈H₁₂N
• 分子量: 202.094
• InChiKey: QTXZDFXPUPKBJC-UHFFFAOYSA-M

物化性质

• 熔点：
  95 °C
• 溶解度：
  溶于甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  -1.69
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 储存条件：
  室温且干燥

反应信息

• 作为反应物：
  描述：

  1-乙基-2-甲基溴化吡啶 在 哌啶 作用下， 以 乙醇 、 水 、 丙酮 为溶剂， 反应 96.0h， 生成 2-[4-(diethylamino)styryl]-1-ethylpyridinium bis(perfluorobutylsulfonyl)imide
  参考文献：
  名称：

  吡啶鎓苯乙烯基染料的固态荧光

  摘要：

  1-烷基-2- [4-（二乙基氨基）苯乙烯基]吡啶鎓盐根据烷基和抗衡阴离子在固态下在650 nm处显示最大荧光。双（全氟丁基磺酰基）酰亚胺的1-丁基-2- [4-（二乙氨基）苯乙烯基]吡啶鎓在652 nm处显示最大荧光，且结晶形式的最高量子产率为0.16。单个X射线晶体学表明该化合物表现出分离的二聚体型堆积，从而导致固态荧光。

  DOI：

  10.1016/j.dyepig.2013.07.026
• 作为产物：
  描述：

  碳酸甲丙酯 、 溴乙烷 以 乙腈 为溶剂， 反应 16.0h， 以4.3 g的产率得到1-乙基-2-甲基溴化吡啶
  参考文献：
  名称：

  β-Dicétoénamineshétérocycliques：2.（吡啶基-4）-2茚满二酮-1,3 C -et N-取代基

  摘要：

  取代基（吡啶基-4）-2茚二酮-1,3取代了N-取代基。邻苯二甲酸酯单缩合的多吡啶缩合物，混合酸和氮杂取代的N-烷基吡啶基双吡啶-1,3的溴代氧合缩醛。负离子光谱学观察者，电子观察光谱学派生N-替代物，传统形式的限制性研究对象。

  DOI：

  10.1002/jhet.5570170530

文献信息

• Five new Sb(V) bromide complexes and their polybromide derivatives with pyridinium-type cations: Structures, thermal stability and features of halogen⋯halogen contacts in solid state
  作者：Sergey A. Adonin、Mikhail A. Bondarenko、Alexander S. Novikov、Pavel E. Plyusnin、Ilya V. Korolkov、Maxim N. Sokolov、Vladimir P. Fedin

  DOI：10.1016/j.ica.2019.119278

  日期：2020.3

  Abstract Reactions of Sb2O3 solution in HBr in presence of Br2 with series of pyridinium-type cation salts resulted in formation of Cat[SbBr6] (Cat = 1,3,4-MePy+ (1) and 1,4-MePy+ (2)) and Cat2[SbBr6](Br3)} (Cat = 1,2-MePy+ (3), 1-Et-2-MePy+ (4) and 1-Et-4-MePy+ (5)) complexes which were characterized by X-ray diffractometry. For all compounds, thermal stability was investigated by TGA method; energies

  摘要在Br2存在下，Sb2O3在HBr中的溶液与一系列吡啶鎓型阳离子盐反应，导致形成Cat [SbBr6]（Cat = 1,3,4-MePy +（1）和1,4-MePy +（2））和特征为X的Cat2 [SbBr6]（Br3）}（Cat = 1,2-MePy +（3），1-Et-2-MePy +（4）和1-Et-4-MePy +（5））络合物射线衍射法。对于所有化合物，通过TGA方法研究其热稳定性。通过DFT计算和QTAIM分析（M06 / DZP-DKH理论水平）估算了非共价Br⋯Br相互作用的能量。
• In Situ Observation of mtDNA Damage during Hepatic Ischemia-Reperfusion
  作者：Wen Zhang、Simin Bi、Ping Li、Jihong Liu、Chunmiao Zhou、Xin Wang、Wei Zhang、Hui Wang、Bo Tang

  DOI：10.1021/acs.analchem.0c05220

  日期：2021.4.13

  Hepatic ischemia-reperfusion (IR) injury is a severe pathophysiological event during liver surgery or transplantation and could lead to liver failure or even death. The energy supply of mitochondria plays an essential role in preventing IR injury. Mitochondrial DNA (mtDNA) is involved in maintaining the balance of energy by participating in an oxidative phosphorylation process. However, the exact relationship between IR and mtDNA remains unclear by reason of the lack of an accurate real-time analysis method. Herein, we fabricated a mitochondria-targeting fluorescent probe (mtDNA-BP) to explore mtDNA stability and supervise the changes in mtDNA in IR liver. By virtue of pyridinium electropositivity and suitable size, mtDNA-BP could accumulate in mitochondria and insert into the mtDNA groove, which made mtDNA-BP fluoresce strongly. This is attributed to the reduction of the intramolecular rotation energy loss that is restricted by DNA. By in situ fluorescence imaging, we observed in real time that mtDNA damage was aggravated by deteriorating IR injury, so the ROS-mtDNA-mediated IR damage signal pathway was speculated. Furthermore, on the basis of mtDNA-BP real-time response capability for mtDNA, we established a drug-screening method for inhibiting IR injury and found superior therapeutic performance of two potential drugs: pioglitazone and salidroside. This work contributes to our understanding of mtDNA-related disease and provides a new drug analysis method.

  肝脏缺血-再灌注（IR）损伤是肝脏手术或移植期间发生的严重生理病理事件，可能导致肝功能衰竭甚至死亡。线粒体的能量供应在防止IR损伤中起着至关重要的作用。线粒体DNA（mtDNA）通过参与氧化磷酸化过程，参与维持能量平衡。然而，由于缺乏准确的实时分析方法，IR与mtDNA之间的确切关系仍不清楚。在此，我们制造了一种靶向线粒体的荧光探针（mtDNA-BP），以探索mtDNA的稳定性并监督IR肝脏中mtDNA的变化。凭借吡啶阳离子的优良电正性和合适的尺寸，mtDNA-BP能够在线粒体中积累并插入mtDNA的凹槽，从而使mtDNA-BP强烈荧光。这是由于DNA限制了分子内旋转能量损失的减少。通过原位荧光成像，我们实时观察到mtDNA损伤因IR损伤加重而加剧，因此推测出了一条以ROS-mtDNA为介导的IR损伤信号通路。此外，基于mtDNA-BP对mtDNA的实时响应能力，我们建立了一种抑制IR损伤的药物筛选方法，并发现了两种潜在药物的优越治疗效果：吡格列酮和沙利度胺。这项工作有助于我们对mtDNA相关疾病的理解，并提供了一种新的药物分析方法。
• [EN] PROCESSES FOR PREPARING L-ALKYL-3-ALKYL-PYRIDINIUM BROMIDE AND USES THEREOF AS ADDITIVES IN ELECTROCHEMICAL CELLS<br/>[FR] PROCÉDÉS POUR LA PRÉPARATION DE BROMURE DE 1-ALKYL-3-ALKYLPYRIDINIUM ET SES UTILISATIONS COMME ADDITIF DANS DES CELLULES ÉLECTROCHIMIQUES
  申请人：BROMINE COMPOUNDS LTD

  公开号：WO2014122641A1

  公开（公告）日：2014-08-14

  The invention relates to the use of at least one l-alkyl-3- alkyl-pyridinium halide, in particular l-alkyl-3-methyl- pyridinium bromide, as an additive in bromine-generating electrochemical cells, such as zinc/bromine cells. Processes for preparing l-alkyl-3-methyl-pyridinium bromide and concentrated aqueous solutions comprising same for use as additives in the aforementioned cells, are also disclosed.

  本发明涉及在产生溴的电化学电池中使用至少一种l-烷基-3-烷基-吡啶盐，特别是l-烷基-3-甲基-溴化吡啶，作为添加剂。还公开了制备l-烷基-3-甲基-溴化吡啶和含有该物质的浓缩水溶液用作上述电池添加剂的方法。
• [EN] PROCESSES FOR PREPARING N-ETHYL-2-METHYLPYRIDINIUM BROMIDE AND N-ETHYL-3-METHYLPYRIDINIUM BROMIDE<br/>[FR] PROCÉDÉS DE PRÉPARATION DE BROMURE DE N-ÉTHYL-2-MÉTHYLPYRIDINIUM ET DE BROMURE DE N-ÉTHYL-3-MÉTHYLPYRIDINIUM
  申请人：BROMINE COMPOUNDS LTD

  公开号：WO2013042109A1

  公开（公告）日：2013-03-28

  The invention provides processes for preparing concentrated aqueous solutions of N-ethyl-2-methylpyridinium bromide and N- ethyl-3-methylpyridinium bromide, which solutions are useful as additives in the electrolyte of hydrogen/bromine electrochemical cells. Also provided are concentrated aqueous solutions of N-ethyl-2-methylpyridinium bromide, N-ethyl-3-methylpyridinium bromide and their mixtures.

  该发明提供了制备浓缩水溶液N-乙基-2-甲基吡啶溴化物和N-乙基-3-甲基吡啶溴化物的方法，这些溶液可作为氢/溴电化学电池电解质中的添加剂。同时提供了N-乙基-2-甲基吡啶溴化物、N-乙基-3-甲基吡啶溴化物及它们的混合物的浓缩水溶液。
• Polymerizable composition, optical material comprising the composition and method for producing the material
  申请人：——

  公开号：US20040254258A1

  公开（公告）日：2004-12-16

  A cured matter obtained by polymerizing and curing a polymerizable composition comprising a compound having at least one episulfide in a molecule is reduced in an odor by adding a perfume to the polymerizable composition comprising the compound having at least one episulfide in a molecule. A cloudiness of the lens is removed by raising a purity of sulfur to 98% or more. A reduction in a chlorine content of the sulfur compound described above to 0.1% by weight or less elevates an oxidation resistance and a light fastness of the high refractive index optical material and improves a color tone thereof. An optical product having a high refractive index and a high-degree transparency is provided by subjecting the composition in advance to deaerating treatment at 0 to 100° C. for one minute to 24 hours under a reduced pressure of 0.001 to 50 torr.

  通过聚合和固化至少含有一种环硫醚的化合物的可聚合组合物获得的治愈物质，通过向至少含有一种环硫醚的化合物的可聚合组合物中添加香水来减少其气味。通过将硫的纯度提高到98％或更高，可以消除镜片的混浊。将上述硫化合物的氯含量降低至0.1％或更低可以提高高折射率光学材料的氧化抗性和耐光性，并改善其色调。通过在0至100°C下将组合物事先进行脱气处理，以在0.001至50 torr的减压下持续1分钟至24小时，可提供具有高折射率和高度透明度的光学产品。