1-乙基-6-甲氧基喹啉-1-鎓氯化物 | 134907-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 1-乙基-6-甲氧基喹啉-1-鎓氯化物
• 英文名称: 6-Methoxy-N-ethylquinolinium
• 英文别名: 1-ethyl-6-methoxyquinolin-1-ium;chloride
• CAS: 134907-10-1
• 化学式: C12H14ClNO
• 分子量: 223.7
• InChiKey: JFDLMJJVKVMQAW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.84
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Development of an anionic sensor for living cells: application to the human glycine receptor
  申请人：INSTITUT PASTEUR

  公开号：EP1514922A1

  公开（公告）日：2005-03-16

  The subject of the invention is a polypeptide comprising a new mutant enhanced yellow fluorescent protein (EYFP) having anion binding properties, which may be further fused with an enhanced cyan fluorescent protein (ECFP) and further to a peptide linker inserted between said mutant EYFP and ECFP, thereby forming an anionic sensor, said anionic sensor may further be inserted in a transmembrane anionic channel. A complex comprising a transmembrane ionic channel and a polypeptidic biosensor is also disclosed. Also disclosed are nucleic acids and vectors, host cells and transgenic organisms thereof. Also disclosed herein are a method for preparing transformed cells capable of expressing ionic sensors at the vicinity of said ionic channels, methods for determining and monitoring dynamic changes in ion concentrations in cells, methods of selecting compounds capable of modifying said dynamic changes, sensing fluorescent microspheres and kits thereof.

  本发明的主题是一种多肽，包括一种具有阴离子结合特性的新突变增强型黄色荧光蛋白（EYFP），该蛋白可进一步与增强型青色荧光蛋白（ECFP）融合，并进一步与插入所述突变EYFP和ECFP之间的肽链连接，从而形成阴离子传感器，所述阴离子传感器可进一步插入跨膜阴离子通道。还公开了一种由跨膜离子通道和多肽生物传感器组成的复合物。还公开了核酸和载体、宿主细胞及其转基因生物。本文还公开了制备能在所述离子通道附近表达离子传感器的转化细胞的方法、确定和监测细胞中离子浓度动态变化的方法、选择能改变所述动态变化的化合物的方法、传感荧光微球及其试剂盒。
• Methods of treating brain edema
  申请人：Snutch Terrance P.

  公开号：US10472635B2

  公开（公告）日：2019-11-12

  Provided are methods for treating or preventing brain edema in a subject by administering an inhibitor of SLC26A11 to the subject. Also included are methods for preventing cell death, cell swelling, or elevated internal concentration of chloride ions in a cell by contacting the cell with an inhibitor of SLC26A11.

  本发明提供了通过向受试者施用 SLC26A11 抑制剂来治疗或预防受试者脑水肿的方法。还包括通过使细胞与 SLC26A11 抑制剂接触来防止细胞死亡、细胞肿胀或细胞内氯离子浓度升高的方法。
• METHODS OF TREATING BRAIN EDEMA
  申请人：SNUTCH Terrance P.

  公开号：US20180195075A1

  公开（公告）日：2018-07-12

  Provided are methods for treating or preventing brain edema in a subject by administering an inhibitor of SLC26A11 to the subject. Also included are methods for preventing cell death, cell swelling, or elevated internal concentration of chloride ions in a cell by contacting the cell with an inhibitor of SLC26A11.
• US6806089B1
  申请人：——

  公开号：US6806089B1

  公开（公告）日：2004-10-19
• [EN] LOW FREQUENCY MODULATION SENSORS USING NANOSECOND FLUOROPHORES<br/>[FR] CAPTEURS DE MODULATION BASSE FREQUENCE UTILISANT DES FLUOROPHORES NANOSECONDE
  申请人：UNIV MARYLAND

  公开号：WO2000014515A1

  公开（公告）日：2000-03-16

  Described is a new approach to fluorescence sensing based on a mixture of fluorophores, one of which is sensitive to the desired analyte. If a long lifetime analyte-insensitive fluorophore is mixed with a short lifetime analyte-sensitive fluorophore, the modulation of the emission at conveniently low frequencies becomes equal to the fractional fluorescence intensity of the sensing fluorophore. Under these conditions the modulation can be used to determine the analyte concentration. This can be used with any fluorophore which changes intensity in response to analyte, and does not require the sensing fluorophore to display a change in lifetime. The feasibility of modulation-based sensing was demonstrated using mixtures of 6-carboxyfluorescein and [Ru2,2'(bipyridyl)3]2+ as a pH sensor and of the calcium probe Fluo-3 and [Ru2,2'(bipyridyl)¿3]?2+ as a calcium sensor.