1-乙氧基戊烷-3-醇 | 100910-92-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-乙氧基戊烷-3-醇
• 英文名称: 1-ethoxy-pentan-3-ol
• 英文别名: 1-Aethoxy-pentan-3-ol；1-Ethoxypentan-3-ol
• CAS: 100910-92-7
• 化学式: C₇H₁₆O₂
• 分子量: 132.203
• InChiKey: LQIBOAZAEQOEMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-乙氧基戊烷-3-醇 在 四氢呋喃 、 三溴化磷 、 magnesium 作用下， 生成 乙基环丙烷
  参考文献：
  名称：

  CYCLOPROPANE HYDROCARBONS FROM gamma-BROMOETHERS¹

  摘要：

  DOI：

  10.1021/jo01121a001
• 作为产物：
  描述：

  乙基-(3-氯-戊基)-醚 在 乙醚 、 magnesium 作用下， 生成 1-乙氧基戊烷-3-醇
  参考文献：
  名称：

  Mamedow; Pischnamassade, Zhurnal Obshchei Khimii, 1958, vol. 28, p. 1834,1836,1837;engl.Ausg.S.1879,1881,1882

  摘要：

  DOI：

文献信息

• [EN] 2-AMINOQUINOLINES AS MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS<br/>[FR] 2-AMINOQUINOLINES SERVANT D'ANTAGONISTES DE RECEPTEUR DE L'HORMONE DE CONCENTRATION DE MELANINE
  申请人：ABBOTT LAB

  公开号：WO2003105850A1

  公开（公告）日：2003-12-24

  The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

  本发明涉及公式(I)的化合物，或其治疗上适用的盐或前药，这些化合物通过黑素浓集激素受体拮抗黑素浓集激素（MCH）的效果，并且用于预防或治疗进食障碍、体重增加和肥胖。
• Heterocyclic compounds as P2X7 ion channel blockers
  申请人：Shum Patrick

  公开号：US20050026916A1

  公开（公告）日：2005-02-03

  The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.

  本发明涉及一种新的4,5-二苯基-2-氨基-4,5-二氢咪唑衍生物系列，其化学式为II： 其中R、R1、R2、R3、R4、R5、X和Y如本文所定义。本发明还涉及制备这些化合物的方法。本发明的化合物是P2X7离子通道阻断剂，因此在作为药用剂方面具有用途，特别是在治疗和/或预防具有炎症成分的各种疾病方面，包括炎症性肠病、类风湿关节炎以及与中枢神经系统相关的疾病状况，如中风、阿尔茨海默病等。
• 2-Aminoquinolines as melanin concentrating hormone receptor antagonists
  申请人：——

  公开号：US20040063756A1

  公开（公告）日：2004-04-01

  The present invention is related to compounds of formula (I), 1 or a therapeutically suitable salt or prodrug thereof, which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor and are useful for the prevention or treatment of eating disorders, weight gain and obesity.

  本发明涉及式(I)的化合物，或其治疗上适宜的盐或前药，通过黑素浓集激素受体拮抗黑素浓集激素（MCH）的作用，并且对于预防或治疗进食障碍、体重增加和肥胖症是有用的。
• HETEROCYCLIC COMPOUNDS AS P2X7 ION CHANNEL BLOCKERS
  申请人：SHUM Patrick

  公开号：US20080132550A1

  公开（公告）日：2008-06-05

  The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.

  本发明涉及一种新的4,5-二苯基-2-氨基-4,5-二氢咪唑衍生物系列，其化学式为II：其中R、R1、R2、R3、R4、R5、X和Y如本文所定义。本发明还涉及制备这些化合物的方法。本发明的化合物是P2X7离子通道阻滞剂，因此在治疗和/或预防具有炎症成分的多种疾病方面，包括炎症性肠病、类风湿性关节炎以及与中枢神经系统相关的疾病状态，如中风、阿尔茨海默病等方面，具有药物学上的用途。
• DIGITAL CERAMIC INKJET INKS FOR GLASS AND METHOD FOR OBTAINING SAME
  申请人：Tecglass SL

  公开号：EP3845614A1

  公开（公告）日：2021-07-07

  Ceramic inkjet inks for non-porous substrates (such as glass, metals) whereby the viscosity of the inks at the jetting temperature of 33-50°C is 8-20 mPa.s and increase substantially to more than a factor of 5 (greater than 100 mPa.s) after landing on the substrate. The invention also relates to processing/formulating steps and tuning of the bulk and dynamic properties suitable for (i) inkjet printing in the printhead channel and (ii) desirable high viscosity after landing on the glass substrate. The ink comprises: Glass Frit composition which is in the form of particles having a volume particle size distribution Dv90 of less than 1.5 µm, carriers (30-50wt %) and additives (0-10%). The ceramic ink mitigate ink splattering, spreading during and after landing, eliminate/reduce image defects because of dust contaminations from the environment on wet inks after printing

  用于无孔基材（如玻璃、金属）的陶瓷喷墨墨水，在 33-50°C 的喷射温度下，墨水的粘度为 8-20 mPa.s，在落到基材上后，粘度大幅增加到 5 倍以上（大于 100 mPa.s）。本发明还涉及加工/配制步骤以及调整体积和动态特性，以适合 (i) 喷头通道中的喷墨打印和 (ii) 落在玻璃基底上后的理想高粘度。墨水包括玻璃熔块成分，其颗粒的体积粒度分布 Dv90 小于 1.5 µm，载体（30-50wt %）和添加剂（0-10%）。陶瓷墨水可减轻油墨飞溅、着墨时和着墨后的扩散，消除/减少因印刷后环境中的灰尘污染湿油墨而造成的图像缺陷。