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1-氨基-1-脱氧-D-葡萄糖醇盐酸盐 | 104833-43-4

中文名称
1-氨基-1-脱氧-D-葡萄糖醇盐酸盐
中文别名
——
英文名称
1-amino-1-deoxy-D-glucitol hydrochloride
英文别名
(2R,3R,4R,5S)-6-aminohexane-1,2,3,4,5-pentol;hydrochloride
1-氨基-1-脱氧-D-葡萄糖醇盐酸盐化学式
CAS
104833-43-4
化学式
C6H16NO5*Cl
mdl
——
分子量
217.65
InChiKey
GTGZGTMCSYIRON-BTVCFUMJSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    -3.2
  • 重原子数:
    13
  • 可旋转键数:
    5
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    1.0
  • 拓扑面积:
    127
  • 氢给体数:
    7
  • 氢受体数:
    6

SDS

SDS:9d4711fadfcf49892681589d8d38506f
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反应信息

  • 作为反应物:
    描述:
    1-氨基-1-脱氧-D-葡萄糖醇盐酸盐吡啶triflic azidepotassium carbonate 、 copper(II) sulfate 作用下, 以 甲醇 为溶剂, 反应 56.0h, 生成 1-azido-6-O-(tert-butyldiphenylsilyl)-1-deoxy-D-glucitol
    参考文献:
    名称:
    通过收敛环封闭复分解方法制备的基于碳水化合物的大环内酯类药物:寻找新型抗生素。
    摘要:
    已经开发出一种有效的收敛方法来构建新颖的,非天然的多取代碳水化合物基大环内酯类化合物。合成中的关键步骤是通过闭环易位反应形成大环。已经筛选了获得的大环内酯类似物对革兰氏阳性和革兰氏阴性细菌,酵母和霉菌的生物活性。
    DOI:
    10.1021/jo061929q
  • 作为产物:
    描述:
    D-glucose oxime 氢气 作用下, 以 甲醇 为溶剂, 100.0 ℃ 、16.0 kPa 条件下, 反应 12.0h, 以44%的产率得到1-氨基-1-脱氧-D-葡萄糖醇盐酸盐
    参考文献:
    名称:
    Pischel, Helmut; Holy, Antonin; Vesely, Jiri, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 8, p. 2061 - 2069
    摘要:
    DOI:
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文献信息

  • Metallkomplexe mit biologisch wichtigen Liganden, CXXXI*. Pentamethylcyclopentadienyl-Halbsandwich-Komplexe von Rhodium und Iridium mit Glycosyl-«-iminocarboxylaten als Chelat-Liganden / M etal C om plexes of Biologically Im portant Ligands, CXXXI*. Pentam ethylcyclopentadienyl Halfsandwich Complexes of Rhodium and Iridium with Glycosyl-a-im inocarboxylates as Chelate Ligands
    作者:Stefan Krawielitzki、Wolfgang Beck
    DOI:10.1515/znb-2001-0110
    日期:2001.1.1
    Abstract

    The N-glycosyl-iminocarboxylate complexes Cp*M(Cl)N(R)=C(R')CO2 (M = Rh, Ir; R = glycosyl, R ’ = Me, Ph, CH2CHMe2) with a chiral metal atom are formed in a template reaction from [Cp*MCl2]2 (M = Rh, Ir), the 2-keto carboxylic acid and tetra-O-acetyl-β-Dglucosamine, D-glucosamine or D-glucamine as mixtures of two diastereoisomers and were characterized by analytical and spectroscopic methods.

    摘要:在模板反应中,具有手性金属原子的N-糖基-亚胺羧酸盐Cp*M(Cl)N(R)=C(R')CO2(M = Rh, Ir; R = 糖基,R' = 甲基,苯基,CH2CHMe2)由[Cp*MCl2]2(M = Rh, Ir)、2-酮羧酸和四-O-乙酰基-β-D葡萄糖胺、D-葡萄糖胺或D-葡萄胺的混合物形成,并通过分析和光谱方法进行了表征。
  • Protecting-Group-Free Synthesis of Amines: Synthesis of Primary Amines from Aldehydes via Reductive Amination
    作者:Emma M. Dangerfield、Catherine H. Plunkett、Anna L. Win-Mason、Bridget L. Stocker、Mattie S. M. Timmer
    DOI:10.1021/jo100004c
    日期:2010.8.20
    New methodology for the protecting-group-free synthesis of primary amines is presented. By optimizing the metal hydride/ammonia mediated reductive amination of aldehydes and hemiacetals, primary amines were selectively prepared with no or minimal formation of the usual secondary and tertiary amine byproduct. The methodology was performed on a range of functionalized aldehyde substrates, including in
    提出了一种新的无保护基合成伯胺的方法。通过优化金属氢化物/氨介导的醛和半缩醛的还原胺化反应,可以选择性地制备伯胺,而不会或很少会形成通常的仲胺和叔胺副产物。该方法是在一系列功能化的醛底物上进行的,包括从Vasella反应中原位形成的醛。这些还原性胺化条件提供了有价值的合成工具,用于以较少的步骤,良好的收率并且不使用保护基团来选择性生产伯胺。
  • PYRIMIDO-PYRROLO-QUINOXALINEDIONE INHIBITORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND USES THEREFOR
    申请人:Verkman Alan S.
    公开号:US20120208822A1
    公开(公告)日:2012-08-16
    Provided herein are pyrimido-pyrrolo-quinoxalinedione (PPQ) compounds, and compositions comprising these compounds, that inhibit cystic fibrosis transmembrane conductance regulator (CFTR) mediated ion transport and that are useful for treating diseases and disorders associated with aberrantly increased CFTR chloride channel activity. The compounds, and compositions comprising the compounds, described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, polycystic kidney disease. The compounds may be used for inhibiting expansion or preventing formation of cysts in persons who have polycystic kidney disease.
    本文提供了嘧啶并吡咯并喹啉二酮(PPQ)化合物和包含这些化合物的组合物,它们抑制囊性纤维化跨膜传导调节因子(CFTR)介导的离子传输,并且可用于治疗与异常增加的CFTR氯离子通道活性相关的疾病和疾病。本文所述的化合物和包含这些化合物的组合物可用于治疗与异常增加的CFTR活性相关的疾病、疾病和病情后遗症,例如多囊肾病。这些化合物可用于抑制多囊肾病患者的囊肿扩张或预防囊肿的形成。
  • Method of crosslinking glycosaminoglycans
    申请人:Galderma Research & Development
    公开号:US11214655B2
    公开(公告)日:2022-01-04
    A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan.
    一种由交联糖胺聚糖,特别是交联透明质酸、软骨素或硫酸软骨素制成的新型水凝胶,其硼酸或硼氧衍生物的可逆连接可带来新的益处。通过接枝到第一个氨基聚糖的二元醇官能团的二元醇部分与接枝到第二个氨基聚糖的硼酸半酯之间形成的烷氧基硼酸酯阴离子交联的氨基聚糖。
  • Nitrite scavenging formulation to reduce formation of nitrosamines during chewing of food items such as chewing tobacco and betel nuts
    申请人:——
    公开号:US20030175367A1
    公开(公告)日:2003-09-18
    This invention describes a formulation that removes or reduces the formation of nitrosamines when chewing food items such as chewing tobacco, betel nuts, and fruits that contain secondary amines or imines, or other manufactured food items containing sources of amines and imines that could form chemically stable nitrosamines with nitrites in saliva. Nitrosamines are known carcinogens.
    本发明描述了一种配方,当咀嚼含有仲胺或亚胺的食品,如咀嚼烟草、槟榔和水果,或其他含有胺和亚胺来源的制成品食品时,该配方可消除或减少亚硝胺的形成,因为亚硝胺可与唾液中的亚硝酸盐形成化学稳定的亚硝胺。亚硝胺是已知的致癌物质。
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