作者:Erin D. Anderson、Adam S. Duerfeldt、Kaicheng Zhu、Christopher M. Glinkerman、Dale L. Boger
DOI:10.1021/ol502436n
日期:2014.10.3
The scope of the [4 + 2] cycloaddition reactions of substituted 1,2,3-triazines, bearing noncomplementary substitution with electron-withdrawing groups at C4 and/or C6, is described. The studies define key electronic and steric effects of substituents impacting the reactivity, mode (C4/N1 vs C5/N2), and regioselectivity of the cycloaddition reactions of 1,2,3-triazines with amidines, enamines, and
描述了取代的 1,2,3-三嗪的 [4 + 2] 环加成反应的范围,在 C4 和/或 C6 上带有吸电子基团的非互补取代。这些研究定义了影响 1,2,3-三嗪与脒、烯胺和炔胺的环加成反应的反应性、模式(C4/N1 与 C5/N2)和区域选择性的取代基的关键电子和空间效应,提供了获得高度功能化的杂环。