1-氨基-4-羟基丁烷-2-酮 | 87395-84-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-氨基-4-羟基丁烷-2-酮
• 英文名称: 1-amino-4-hydroxy-2-butanone
• 英文别名: 1-Amino-4-hydroxybutan-2-one
• CAS: 87395-84-4
• 化学式: C₄H₉NO₂
• 分子量: 103.121
• InChiKey: NHIYVTWYOQHMTG-UHFFFAOYSA-N

物化性质

• 沸点：
  231.4±20.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-Azido-4-hydroxybutan-2-one 在 1% Pd/C 、 氢气 、 盐酸 、 水 作用下， 生成 1-氨基-4-羟基丁烷-2-酮
  参考文献：
  名称：

  Probing the active site of rat porphobilinogen synthase using newly developed inhibitors

  摘要：

  The structurally related tetrapyrrolic pigments are a group of natural products that participate in many of the fundamental biosynthetic and catabolic processes of living organisms. Porphobilinogen synthase catalyzes a rate-limiting step for the biosyntheses of tetrapyrrolic natural products. In the present study, a variety of new substrate analogs and reaction intermediate analogs were synthesized, which were used as probes for studying the active site of rat porphobilinogen synthase. The compounds 1, 3, 6, 9, 14, 16, and 28 were found to be competitive inhibitors of rat porphobilinogen synthase with inhibition constants ranging from 0.96 to 73.04 mM. Compounds 7, 10, 12, 13, 15, 17, 18, and 26 were found to be irreversible enzyme inhibitors. For irreversible inhibitors, loose-binding inhibitors were found to give stronger inactivation. The amino group and carboxyl group of the analogs were found to be important for their binding to the enzyme. This study increased our understanding of the active site of porphobilinogen synthase. (C) 2008 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2008.11.001

文献信息

• Finn, Malcolm J.; Harris, Michael A.; Hunt, Eric, Journal of the Chemical Society. Perkin transactions I, 1984, p. 1345 - 1349
  作者：Finn, Malcolm J.、Harris, Michael A.、Hunt, Eric、Zomaya, Iskander I.

  DOI：——

  日期：——
• Probing the active site of rat porphobilinogen synthase using newly developed inhibitors
  作者：Nan Li、Xiusheng Chu、Xiaojun Liu、Ding Li

  DOI：10.1016/j.bioorg.2008.11.001

  日期：2009.2

  The structurally related tetrapyrrolic pigments are a group of natural products that participate in many of the fundamental biosynthetic and catabolic processes of living organisms. Porphobilinogen synthase catalyzes a rate-limiting step for the biosyntheses of tetrapyrrolic natural products. In the present study, a variety of new substrate analogs and reaction intermediate analogs were synthesized, which were used as probes for studying the active site of rat porphobilinogen synthase. The compounds 1, 3, 6, 9, 14, 16, and 28 were found to be competitive inhibitors of rat porphobilinogen synthase with inhibition constants ranging from 0.96 to 73.04 mM. Compounds 7, 10, 12, 13, 15, 17, 18, and 26 were found to be irreversible enzyme inhibitors. For irreversible inhibitors, loose-binding inhibitors were found to give stronger inactivation. The amino group and carboxyl group of the analogs were found to be important for their binding to the enzyme. This study increased our understanding of the active site of porphobilinogen synthase. (C) 2008 Elsevier Inc. All rights reserved.