1-溴十四烷-2-酮 | 133794-61-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-溴十四烷-2-酮
• 英文名称: 1-bromotetradecan-2-one
• CAS: 133794-61-3
• 化学式: C₁₄H₂₇BrO
• 分子量: 291.272
• InChiKey: CVNRXYGLZPPQHP-UHFFFAOYSA-N

物化性质

• 沸点：
  338.1±15.0 °C(Predicted)
• 密度：
  1.079±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  16
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-溴十四烷-2-酮 在 ammonium hydroxide 、 碘 作用下， 反应 1.0h， 以70.4 mg的产率得到十三烷酸[2,6-二乙基-2,3,6-三甲基-1-(1-苯基-乙氧基)-哌啶-4-基]-酰胺
  参考文献：
  名称：

  1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化

  摘要：

  通过用1，3-二溴-5，5-二甲基乙内酰脲处理，然后与分子碘和HCl水溶液反应，将多种末端烯烃在水中以25-86％的产率转化为相应的酰胺。一锅中加入NH 3（或胺）。这种无金属和有机溶剂的方案不仅适用于苯乙烯衍生物，而且首次在末端脂族烯烃上效果很好。

  DOI：

  10.1039/c7ob02329d
• 作为产物：
  描述：

  1-十四烯 在 1,3-二溴-5,5-二甲基海因 、 水 作用下， 反应 2.0h， 生成 1-溴十四烷-2-酮
  参考文献：
  名称：

  1,3-二溴-5,5-二甲基乙内酰脲介导的末端烯烃在水中的氧化酰胺化

  摘要：

  通过用1，3-二溴-5，5-二甲基乙内酰脲处理，然后与分子碘和HCl水溶液反应，将多种末端烯烃在水中以25-86％的产率转化为相应的酰胺。一锅中加入NH 3（或胺）。这种无金属和有机溶剂的方案不仅适用于苯乙烯衍生物，而且首次在末端脂族烯烃上效果很好。

  DOI：

  10.1039/c7ob02329d

文献信息

• Facile one-pot synthesis of α-bromoketones from olefins using bromide/bromate couple as a nonhazardous brominating agent
  作者：Rajendra D. Patil、Girdhar Joshi、Subbarayappa Adimurthy、Brindaban C. Ranu

  DOI：10.1016/j.tetlet.2009.03.047

  日期：2009.5

  A new method for the preparation of α-bromoketones from olefins using bromide/bromate couple as a nonhazardous brominating agent has been developed. Several α-bromoketones were successfully prepared from a variety of olefins by this method. This procedure is an alternative to conventional molecular bromine.

  已开发出一种使用溴化物/溴酸盐对作为无害溴化剂，由烯烃制备α-溴代酮的新方法。通过这种方法成功地由多种烯烃制备了几种α-溴代酮。该方法是常规分子溴的替代方法。
• ASCORBIC ACID DERIVATIVES
  申请人：NIPPON HYPOX LABORATORIES INCORPORATED

  公开号：EP0444199A1

  公开（公告）日：1991-09-04

  A drug effective in preventing and ameliorating dysfunctions of organs caused by active oxygen species and active organic radical species, comprising an ascorbic acid derivative of general formula (I) as the active ingredient in order to solve the problem of in vivo unstableness of conventional drugs, wherein R₂ represents a group selected from among alkylcarbonyl (lower alkyl) groups wherein the terminal alkyl group has 7 to 15 carbon atoms, alkyl groups having 9 to 17 carbon atoms, and alkoxycarbonyl (lower alkyl) groups wherein the terminal alkoxy group has 7 to 20 carbon atoms. Ascorbic acid derivatives of the above general formula, wherein R₂ represents an alkylcarbonyl (lower alkyl) group wherein the terminal alkyl group has 7 to 15 carbon atoms are new substances, and this invention discloses these new substances and a method of producing the same.

  一种有效预防和改善由活性氧和活性有机自由基引起的器官功能障碍的药物，由通式(I)的抗坏血酸衍生物作为活性成分，以解决传统药物在体内不稳定的问题、其中 R₂ 代表选自烷基羰基（低级烷基）（其中末端烷基具有 7 至 15 个碳原子）、烷基（具有 9 至 17 个碳原子）和烷氧基羰基（低级烷基）（其中末端烷氧基具有 7 至 20 个碳原子）的基团。上述通式中，R₂代表烷基羰基（低级烷基），其中末端烷基具有 7 至 15 个碳原子的抗坏血酸衍生物是新物质，本发明公开了这些新物质及其生产方法。
• Acylcarnitine analogues as topical, microbicidal spermicides.
  作者：Prashant S. Savle、Gustavo F. Doncel、Stephen D. Bryant、M. Patricia Hubieki、R. Graham Robinette、Richard D. Gandour

  DOI：10.1016/s0960-894x(99)00423-0

  日期：1999.9

  Acylcarnitine analogues, (+)-6-Carboxylatomethyl-2-alkyl-4,4-dimethylmorpholinium (Z-n, where n = the number of carbons in the alkyl chain), synthesized in multi-gram quantities show in vitro activities as spermicides, anti-HIV agents, and inhibitors of the growth of Candida albicans. Activity improves with increasing chain length. Compound Z-15 is a candidate for further study as a topical, microbicidal spermicide. (C) 1999 Elsevier Science Ltd. All rights reserved.
• 3-O-Alkylascorbic acids as free-radical quenchers: synthesis and inhibitory effect on lipid peroxidation
  作者：Yasunori Nihro、Hideki Miyataka、Tadamitsu Sudo、Hitoshi Matsumoto、Toshio Satoh

  DOI：10.1021/jm00111a034

  日期：1991.7

  A novel series of 3-O-alkylascorbic acids (3-RASA, 3a-n) was synthesized to act as radical scavengers for active oxygen species and free radicals, and their redox potentials and inhibitory effects on lipid peroxidation in rat liver microsomes were evaluated. The redox potentials of the 3-RASA compounds were increased by the substituent group to 90-190 mV above the potential for ascorbic acid (i.e., 3-RASA compounds were harder to oxidize). Although 3-O-dodecylascorbic acid (3c) and 3-O-(decylcarbomethyl)ascorbic acid (3i) differed in their redox potentials, they both markedly inhibited lipid peroxidation in rat liver microsomes to a similar extent (IC50 = 3.1 and 3.3 x 10(-6) M, respectively). Structure-activity relationship studies demonstrated that the anti lipid peroxidation activity of the 3-RASA compounds was markedly dependent upon their hydrophobicity.
• Composition containing thiazole rings, organic semiconductor polymer containing the composition, organic active layer containing the organic semiconductor polymer, organic thin film transistor containing the organic active layer, electronic device containing the organic thin film transistor and method of preparing the same
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP1953155B1

  公开（公告）日：2011-03-02