1-溴戊烷-2-醇 | 26818-03-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 中文名称: 1-溴戊烷-2-醇
• 英文名称: 1-bromopentan-2-ol
• CAS: 26818-03-1
• 化学式: C₅H₁₁BrO
• 分子量: 167.046
• InChiKey: AMCWGHNIYLEOOO-UHFFFAOYSA-N

物化性质

• 沸点：
  77-79 °C(Press: 16-18 Torr)
• 密度：
  1.367±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-溴戊烷-2-醇 在 sodium hydroxide 作用下， 以 水 、 苯 为溶剂， 生成 N-[1-(benzylsulfanyl)pentan-2-yloxymethyl]piperidine
  参考文献：
  名称：

  Synthesis of 2-aminomethoxy-1-benzylsulfanylpentanes

  摘要：

  Mannich condensation of 1-benzylsulfanylpentane with equimolar amounts of formaldehyde and secondary amine gave in 3-4 h at 45-50A degrees C the corresponding 2-aminomethoxy-1-benzylsulfanylpentanes in 72-76% yield.

  DOI：

  10.1134/s1070428011060029
• 作为产物：
  描述：

  戊烯 在 sodium bromate 、 硫酸 、 sodium hydrogensulfite 作用下， 以 水 、 乙腈 为溶剂， 反应 8.0h， 生成 1-溴戊烷-2-醇
  参考文献：
  名称：

  Crause, Chantelle; Van Heerden, Fanie R., South African Journal of Chemistry, 1998, vol. 51, # 1, p. 35 - 41

  摘要：

  DOI：

文献信息

• Synthesis of (±)‐ <i>epi</i> ‐Jungianol by the Gold(I)‐Catalyzed Propargyl Claisen Rearrangement/Hydroarylation Cascade Reaction of Propargyl Vinyl Ethers
  作者：Antonia Rinaldi、Vittoria Langé、Dina Scarpi、Ernesto G. Occhiato

  DOI：10.1002/ejoc.202001555

  日期：2021.2.25

  The total synthesis of epi‐jungianol was carried out by exploiting the gold(I)‐catalyzed propargyl Claisen rearrangement/hydroarylation cascade reaction of substituted propargyl vinyl ethers. The methodology appears suitable for the preparation of natural and bioactive compounds containing the cis 1,3‐disubstituted indane skeleton.

  的总合成外延-jungianol是通过利用金（I） -催化的炔丙基Claisen重排/ hydroarylation级联取代炔丙基乙烯基醚反应来进行。该方法似乎适合制备含有顺式1,3-二取代的茚满骨架的天然和生物活性化合物。
• Synthesis of Aminomethoxy Derivatives of 1-(Butylsulfanyl)alkanes
  作者：I. A. Jafarov、E. H. Mammadbayli、N. A. Jafarova、G. M. Talybov

  DOI：10.1134/s1070428019040055

  日期：2019.4

  Three-component Mannich-type condensation of equimolar amounts of 1-(butylsulfanyl)alkan-2-ols, formaldehyde, and secondary aliphatic and heterocyclic amines at 45–50°C (3–4 h) afforded 65–82% of previously unknown aminomethoxy derivatives which were characterized by elemental analyses and IR, 1H and 13C NMR, and mass spectra. Some of the synthesized compounds were tested for antimicrobial activity

  在45–50°C（3–4 h）等摩尔量的1-（丁基硫烷基）烷基-2-醇，甲醛以及脂肪族和杂环仲胺的三组分曼尼希型缩合反应提供了以前未知的65-82％通过元素分析，IR，1 H和13 C NMR和质谱表征的氨基甲氧基衍生物。测试了一些合成的化合物对革兰氏阴性，革兰氏阳性和带有孢子的细菌和酵母样真菌的抗菌活性；它们显示出比常用抗菌剂更高的活性。含有环胺片段的化合物比从脂肪胺获得的化合物更具活性。建议将测试的化合物用作抗菌剂。
• Synthesis and properties of aminomethyloxy derivatives of (1-Propylsulfanyl)pentane
  作者：I. A. Dzhafarov、E. G. Mamedbeili、T. G. Kyazimova、Kh. I. Gasanov、E. I. Suleimanova

  DOI：10.1134/s1070427210050174

  日期：2010.5

  New 2-aminomethyloxy derivatives of 1-(propylsulfanyl)pentane were prepared by condensation of 1-(propylsulfanyl)pentan-2-ol with formaldehyde and secondary amines. The starting 1-(propylsulfanyl)pentan-2-ol was synthesized by the reaction of 1-propanethiol with 1-bromopentan-2-ol. The structures of the products were proved by elemental analysis, IR and H-1 NMR spectroscopy, and mass spectrometry. The compounds were tested as antimicrobial additives to lubricating oils and as antiseptics against bacteria and fungi.
• Synthesis and properties of aminomethoxy derivatives of 1-(butylsulfanyl)pentane
  作者：E. H. Mamedbeyli、I. A. Jafarov、G. M. Talybov、M. A. Mirzoeva、K. O. Iskenderova、A. N. Hajizade

  DOI：10.1134/s1070363217040090

  日期：2017.4

  New aminomethoxy derivatives of 1-(butylsulfanyl)pentane have been synthesized. The structure of the synthesized compounds was studied by elemental analysis, IR and H-1 NMR spectroscopy, and mass spectrometry. Some specimens of the synthesized compounds were tested as antimicrobial additives to lubricant oil, and as aseptic compounds against bacteria and fungi.
• Kauffmann, Thomas; Fischer, Heinz; Woltermann, Annegret, Chemische Berichte, 1982, vol. 115, # 2, p. 645 - 653
  作者：Kauffmann, Thomas、Fischer, Heinz、Woltermann, Annegret

  DOI：——

  日期：——