氨基嘧啶酮-4-二磷酸二胺-2-C-甲基-D-赤藓糖醇 | 263016-94-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 中文名称: 氨基嘧啶酮-4-二磷酸二胺-2-C-甲基-D-赤藓糖醇
• 英文名称: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
• 英文别名: 4-(5'-diphosphocytidyl)-2C-methyl-D-erythritol；cytidine diphosphate−methylerythritol；4-diphosphocytidyl-2-C-methylerythritol；cytidinediphosphate methylerythritol；CDP-ME；4-CDP-2-C-methyl-D-erythritol；[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S)-2,3,4-trihydroxy-3-methylbutyl] hydrogen phosphate
• CAS: 263016-94-0
• 化学式: C₁₄H₂₅N₃O₁₄P₂
• 分子量: 521.312
• InChiKey: YFAUKWZNPVBCFF-XHIBXCGHSA-N

物化性质

• 沸点：
  861.3±75.0 °C(Predicted)
• 密度：
  2.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.7
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  271
• 氢给体数：
  8
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  氨基嘧啶酮-4-二磷酸二胺-2-C-甲基-D-赤藓糖醇 在 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase 5’-三磷酸腺苷 、 magnesium chloride 、 dithiothreitol 作用下， 以 水 为溶剂， 反应 30.0h， 以2.8 mg的产率得到2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
  参考文献：
  名称：

  Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol kinase

  摘要：

  A nonmevalonate pathway intermediate, 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, is transformed to its 2-phospho-derivative in the presence of ATP by a novel Escherichia coli enzyme, 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00295-1
• 作为产物：
  描述：

  5'-胞苷酸 、 (2R,3S)-2,3,4-三羟基-3-甲基丁基磷酸二氢酯 在 Streptomyces coelicolor MEP ciytidylyl transferase YgbP 作用下， 以 水 为溶剂， 生成 氨基嘧啶酮-4-二磷酸二胺-2-C-甲基-D-赤藓糖醇
  参考文献：
  名称：

  Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor

  摘要：

  The mevalonate-independent biosynthetic pathway to isopentenyl diphosphate and dimethylallyl diphosphate, the universal precursors to the isoprenoids, operates in eubacteria, including Escherichia coli, in algae, and in the plastids of higher plants. A search of the Sanger Centre Streptomyces coelicolor genome database revealed open reading frames with ca. 40-50% identity at the deduced amino acid level to the first three E. coli enzymes of this pathway, corresponding to deoxyxylulose phosphate synthase, deoxyxylulose phosphate reductoisomerase and 2-C-methyl erythritol 4-phosphate cytidylyltransferase. The S. coelicolor genes have been cloned and expressed in E. coli, and the recombinant proteins characterized physically and kinetically. The presence of the corresponding enzyme activities in extracts of S. coelicolor CH999 further supports the operation of the mevalonate-independent pathway in this organism. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00050-5

文献信息

• Formation of 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol from 2-C-methyl-d-erythritol 4-phosphate by 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway
  作者：Tomohisa Kuzuyama、Motoki Takagi†、Kazuhide Kaneda、Tohru Dairi、Haruo Seto

  DOI：10.1016/s0040-4039(99)02143-7

  日期：2000.1

  2-C-Methyl- D-erythritol-4-phosphate is transformed to 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol in the presence of cytidine 5'-triphosphate by a novel Escherichia coli enzyme, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, involved in the nonmevalonate pathway. (C) 2000 Elsevier Science Ltd. All rights reserved.
• VARIANT ISOPRENOID PRODUCING ENZYMES AND USES THEREOF
  申请人：Mendez Michael

  公开号：US20120064629A1

  公开（公告）日：2012-03-15

  This disclosure provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present disclosure provides methods of generating polypeptide variants, for example, variant isoprenoid synthases and/or variant prenyl transferases that have at least one desired property not present in the parent polypeptide. The present disclosure further provides polypeptides and polynucleotides encoding variant polypeptides, as well as vectors and host cells comprising the polynucleotides that encode the variant polypeptides. In other embodiments, the present disclosure provides methods of using the variant polypeptides to generate useful products, such as isoprenoid compounds and/or isoprenoid products.
• BIOFUEL PRODUCTION IN PROKARYOTES AND EUKARYOTES
  申请人：Heaps Nicole A.

  公开号：US20120058535A1

  公开（公告）日：2012-03-08

  Terpene synthases are enzymes that directly convert IPP & DMAPP to terpenes, such as fusicoccadiene. Described herein are methods and compositions for the production of terpenes and terpenoids for use as fuel molecules or other useful components. Genetically engineered enzymes capable of producing terpenes and terpenoids are also described.
• METHODS OF PREPARING OIL COMPOSITIONS FOR FUEL REFINING
  申请人：Goodall Brian L.

  公开号：US20120116138A1

  公开（公告）日：2012-05-10

  Disclosed herein are methods and systems for upgrading (for example, removing heteroatoms, metals, or metalloids) an oil composition derived or extracted from a biomass. The upgraded oil composition can be used to make a desired product, for example, a fuel product.
• US7736881B2
  申请人：——

  公开号：US7736881B2

  公开（公告）日：2010-06-15