尿苷5'-四磷酸酯 | 10003-94-8

• 物质功能分类: 分析化学 - 对照品
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 中文名称: 尿苷5'-四磷酸酯
• 中文别名: 地夸磷索杂质
• 英文名称: Uridine 5'-tetraphosphate
• 英文别名: [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [hydroxy(phosphonooxy)phosphoryl] hydrogen phosphate
• CAS: 10003-94-8
• 化学式: C₉H₁₆N₂O₁₈P₄
• 分子量: 564.12
• InChiKey: SBVYRQFJZOKNGO-XVFCMESISA-N

物化性质

• 密度：
  2.187±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.9
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  305
• 氢给体数：
  8
• 氢受体数：
  18

文献信息

• Synthesis and compositions of 2'-terminator nucleotides
  申请人：Bodepudi Veeraiah

  公开号：US20050037991A1

  公开（公告）日：2005-02-17

  The invention provides compositions the comprise nucleotides and/or nucleosides having blocking groups at 2′-positions of sugar moieties. Methods of synthesizing these nucleic acids are also provided.

  该发明提供了含有在糖基的2′-位置具有阻断基团的核苷酸和/或核苷的组合物。同时还提供了合成这些核酸的方法。
• Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
  申请人：——

  公开号：US20020086851A1

  公开（公告）日：2002-07-04

  The present invention provides methods for the synthesis of a pharmaceutically useful dinucleotide, P 1 , P 4 -di(uridine 5′)-tetraphosphate, and demonstrates the applicability to the production of large quantities. The methods of the present invention substantially reduce the time required to synthesize diuridine tetraphosphate, for example, to three days or less. The tetrasodium, ammonium, lithium and potassium salts of P 1 , P 4 -di(uridine 5′)-tetraphosphate prepared by these methods are stable, soluble, nontoxic, of high purity and easy to handle during manufacture.

  本发明提供了一种用于合成一种药用二核苷酸，即P1，P4-二(尿苷5')-四磷酸盐的方法，并证明其适用于大量生产。本发明的方法大大缩短了合成二尿苷四磷酸所需的时间，例如缩短至三天或更短。通过这些方法制备的P1，P4-二(尿苷5')-四磷酸盐的四钠、铵、锂和钾盐稳定、易溶、无毒、纯度高且易于制造时处理。
• Di(uridine 5'-)tetraphosphate and salts thereof
  申请人：Yerxa R. Benjamin

  公开号：US20050148540A1

  公开（公告）日：2005-07-07

  The present invention are directed to P 1 ,P 4 -di(uridine 5′-)tetraphosphate, tetra-alkali metal salts such as tetrasodium, tetralithium, tetrapotassium, and mixed tetra-alkali metal cations thereof. The tetra alkali metal salts of P 1 ,P 4 -di(uridine 5′-)tetraphosphate are water-soluble, nontoxic, and easy to handle during manufacture. These tetra-monovalent alkali metal salts are more resistant to hydrolysis than the mono-, di-, or tri-acid salts, therefore, they provide an improved stability and a longer shelf life for storage. The present invention also provides methods for the synthesis of P 1 ,P 4 -di(uridine 5′-)tetraphosphate, and its pharmaceutically acceptably acceptable salts thereof, and demonstrates the applicability to the production of large quantities. The methods substantially reduce the time required to synthesize diuridine tetraphosphate, for example, to three days or less.

  本发明涉及P1、P4-二(尿苷5'-)四磷酸、四元碱金属盐如四钠、四锂、四钾及其混合四元碱金属阳离子。P1、P4-二(尿苷5'-)四磷酸的四元碱金属盐是水溶性、无毒且在制造过程中易于处理。这些四价单价碱金属盐比单、双或三酸盐更耐水解，因此提供了更好的稳定性和更长的储存寿命。本发明还提供了合成P1、P4-二(尿苷5'-)四磷酸及其药学上可接受的盐的方法，并证明了其适用于大量生产。这些方法大大缩短了合成二尿苷四磷酸所需的时间，例如缩短到三天或更短。
• DI(URIDINE 5'-)TETRAPHOSPHATE AND SALTS THEREOF
  申请人：Yerxa Benjamin R.

  公开号：US20090326050A1

  公开（公告）日：2009-12-31

  The present invention are directed to P 1 ,P 4 -di(uridine 5′-)tetraphosphate, tetra-alkali metal salts such as tetrasodium, tetralithium, tetrapotassium, and mixed tetra-alkali metal cations thereof. The tetra alkali metal salts of P 1 ,P 4 -di(uridine 5′-)tetraphosphate are water-soluble, nontoxic, and easy to handle during manufacture. These tetra-monovalent alkali metal salts are more resistant to hydrolysis than the mono-, di-, or tri-acid salts, therefore, they provide an improved stability and a longer shelf life for storage. The present invention also provides methods for the synthesis of P 1 ,P 4 -di(uridine 5′-)tetraphosphate, and its pharmaceutically acceptably acceptable salts thereof, and demonstrates the applicability to the production of large quantities. The methods substantially reduce the time required to synthesize diuridine tetraphosphate, for example, to three days or less.

  本发明涉及P1，P4-二（尿苷5'-）四磷酸、四元碱金属盐，如四钠、四锂、四钾和其混合四元碱金属阳离子盐。P1，P4-二（尿苷5'-）四磷酸的四元碱金属盐是水溶性、无毒，并且在制造过程中易于处理。这些四价单价金属盐比单酸盐、二酸盐或三酸盐更具抗水解性，因此它们提供了更好的稳定性和更长的货架寿命。本发明还提供了P1，P4-二（尿苷5'-）四磷酸及其药学上可接受的盐的合成方法，并证明了其适用于大量生产。这些方法大大缩短了合成二尿苷四磷酸所需的时间，例如缩短至三天或更短时间。
• Di(uridine 5')-tetraphosphate and salts thereof
  申请人：——

  公开号：US20040014713A1

  公开（公告）日：2004-01-22

  The present invention are directed to P 1 , P 4 -di(uridine 5′)-tetraphosphate, tetra-alkali metal salts such as tetrasodium, tetralithium, tetrapotassium, and mixed tetra-alkali metal cations thereof. The tetra alkali metal salts of P 1 , P 4 -di(uridine 5′)-tetraphosphate are water-soluble, nontoxic, and easy to handle during manufacture. These tetra-monovalent alkali metal salts are more resistant to hydrolysis than the mono-, di-, or tri-acid salts, therefore, they provide an improved stability and a longer shelf life for storage. The present invention also provides methods for the synthesis of P 1 , P 4 -di(uridine 5′)-tetraphosphate, and its pharmaceutically acceptably acceptable salts thereof, and demonstrates the applicability to the production of large quantities. The methods substantially reduce the time required to synthesize diuridine tetraphosphate, for example, to three days or less.

  本发明涉及P1，P4-二(尿嘧啶5')-四磷酸盐，如四钠盐，四锂盐，四钾盐和其混合四元碱金属阳离子盐。P1，P4-二(尿嘧啶5')-四磷酸盐的四元碱金属盐是水溶性、无毒且易于制造。这些四价单价碱金属盐比单酸盐、二酸盐或三酸盐更耐水解，因此它们提供了更好的稳定性和更长的货架寿命。本发明还提供了P1，P4-二(尿嘧啶5')-四磷酸盐及其药学上可接受的盐的合成方法，并证明了其在大量生产中的适用性。该方法大大缩短了合成二尿嘧啶四磷酸所需的时间，例如缩短至三天或更短时间。